| ²é¿´: 347 | »Ø¸´: 0 | |||||||||
Ç廪SPSгæ (СÓÐÃûÆø)
|
[½»Á÷]
Ç廪´óѧ´¢Áè¿ÎÌâ×éÕÐÆ¸ÉúÎï/»¯Ñ§ÉúÎïѧ¼°Óлú»¯Ñ§²©Ê¿ºó
|
Ç廪´óѧ´¢Áè¿ÎÌâ×éÕÐÆ¸ÉúÎï/»¯Ñ§ÉúÎïѧ¼°Óлú»¯Ñ§²©Ê¿ºó ¿ÎÌâ×鳤¼ò½é£º ´¢Á販ʿ2012Äê±¾¿Æ±ÏÒµÓÚÖйú¿ÆÑ§¼¼Êõ´óѧ»¯Ñ§Ïµ£¬2017ÄêÓÚÃÀ¹úScrippsÑо¿Ëù»ñµÃ»¯Ñ§²©Ê¿Ñ§Î»¡£²©Ê¿ÆÚ¼äʦ´ÓÖøÃûÓлú»¯Ñ§¼ÒJin-Quan Yu½ÌÊÚ£¬´ÓÊÂîÙ´ß»¯Ì¼Çâ¼ü»î»¯·´Ó¦µÄÑо¿¡£Í¬Äê7Ô»ñµÃBrown-Coxe²©Ê¿ºó½±Ñ§½ð²¢¼ÓÈëҮ³´óѧ¿ªÊ¼»¯Ñ§ÉúÎïѧÑо¿£¬ºÏ×÷µ¼Ê¦ÎªÃÀ¹ú¹ú¼Ò¿ÆÑ§Ôº¼°ÒÕÊõ¿ÆÑ§ÔºÔºÊ¿Alanna Schepartz½ÌÊÚºÍDerek Toomre½ÌÊÚ¡£ÔÚ´ËÆÚ¼ä·¢Õ¹ÁË»ùÓÚС·Ö×Ó̽ÕëµÄ¶àÉ«¡¢³¤Ê±¼ä¡¢³¬¸ß·Ö±æ»îϸ°ûÓ«¹â³ÉÏñ¼¼Êõ¡£ËûÓÚ2019Äê¼ÓÈëPROTACÁìÓò´´Ê¼ÈËCraig Crews½ÌÊÚ¿ÎÌâ×é´ÓÊ»¯Ñ§ÉúÎïѧ¼°Ò©ÎﻯѧÑо¿¡£ÔÚ´ËÆÚ¼äÉè¼Æ²¢ºÏ³ÉÁËÊ׸öÄܹ»½µ½âÖ°©µ°°×KRASµÄµ°°×½µ½â°ÐÏòǶºÏÌå (PROTAC)¡£´¢Á販ʿÓÚ2021Äê3Ô¼ÓÈëÇ廪´óѧҩѧԺ¿ªÕ¹¶ÀÁ¢Ñо¿£¬Ñо¿·½ÏòΪ»¯Ñ§ÉúÎïѧ£¬ÐÂÒ©Ñз¢¼°ÐÂÐÍÉúÎï³ÉÏñ¼¼ÊõµÄ¿ª·¢¡£¿ÎÌâ×éÖ÷Ò³£ºchu-lab.org Òò¿ÎÌâÐèÒª£¬ÏÖÕÐÆ¸¾ßÓÐÉúÎï/»¯Ñ§ÉúÎïѧ»òÓлú»¯Ñ§±³¾°µÄ²©Ê¿ºó2-3Ãû¡£Ö÷Òª´ÓÊÂÓ«¹â³ÉÏñ¼¼Êõ¿ª·¢¡¢Ó«¹âÓë×éѧÁªÓü¼ÊõµÄ¿ª·¢¡¢ÒÔ¼°ÐÂÒ©Ñз¢µÈ¹¤×÷¡£ ÕÐÆ¸ÒªÇó£º 1. ·ûºÏÇ廪´óѧ²©Ê¿ºóÕÐÊÕÌõ¼þ£» 2. ÒѾ»òÕß¼´½«ÔÚSCIÆÚ¿¯ÒÔµÚÒ»×÷Õß·¢±íÂÛÎÄ£¬Äܹ»¶ÀÁ¢¿ªÕ¹¿ÆÑй¤×÷£» 3. ¾ßÓÐÉúÎïÒ½Ò©¡¢»¯Ñ§ÉúÎïѧ»òÓлú»¯Ñ§Ïà¹ØÑо¿±³¾°£» 4. Óе°°×ÖÊÖÊÆ××éѧ¡¢Ó«¹â³ÉÏñÏà¹ØÑо¿¾ÑéÕßÓÅÏÈ£» 5. ¾ßÓи߶ȵÄÔðÈÎÐĺÍÉϽøÐÄ£¬¹¤×÷»ý¼«Ö÷¶¯£¬¶Ô¿ÆÑÐÓÐŨºñµÄÐËȤ£» 6. ¾ß±¸¶ÀÁ¢¿ÆÑй¤×÷ÄÜÁ¦ÓëÁ¼ºÃµÄ¿Æ¼¼Ó¢ÎĶÁдÄÜÁ¦¡£ ²©Ê¿ºóÉêÇë²ÄÁÏ£ºÏêϸ¸öÈ˼òÀú£¬Ñо¿¾Àú×ܽáµÈÖ¤Ã÷¹¤×÷ºÍ¿ÆÑÐÄÜÁ¦µÄµç×Ó°æÎļþ¡£ ¸Úλ´ýÓö 1£¬¸Úλ´ýÓö°´ÕÕÇ廪´óѧÏà¹Ø¹æ¶¨Ö´ÐС£¿ÎÌâ×齫¸ù¾Ý¹¤×÷Çé¿öÌṩһ¶¨Éú»î²¹ÖúºÍ¼¨Ð§½±Àø¡£Äêн²»µÍÓÚ25Íò¡£ÁíÍ⣬¸ù¾Ý±¾µ¥Î»Ïà¹Ø¹æ¶¨£¬²©Ê¿ºóÒÔµÚÒ»×÷Õß¡¢Ç廪´óѧΪµÚÒ»µ¥Î»·¢±í¸ßˮƽѧÊõÆÚ¿¯¿É»ñµÃÓзdz£ÓоºÕùÁ¦µÄ¼¨Ð§½±Àø£¨https://postdoctor.tsinghua.edu.cn/£©£» 2£¬»ý¼«Ö§³ÖÌõ¼þÓÅÐãÕßÉêÇë¹ú¼Ò¡°²©Ð¼ƻ®¡±¡¢Ç廪´óѧ¡°Ë®Ä¾Ñ§Õß¡±¼Æ»® £¨https://postdoctor.tsinghua.edu.cn/thu/index.htm£©ÒÔ¼°ÆäËû¶àÖÖÇ廪´óѧ²©Ê¿ºóÖ§³Ö¼Æ»®¡£×ÊÖú¶î¶È×î¸ß40ÍòÔª£¬ÁíÓжàÏÀû±£ÕÏ£» 3£¬Ç廪´óѧÌṩ¿É×âסµÄ²©Ê¿ºó¹«Ô¢£¨»ò½ÏΪÓÅÔ½µÄ×â·¿²¹Ìù£©²¢½â¾ö×ÓÅ®ÈëÔ°¡¢Èëѧ£»ÏíÊÜÇ廪´óѧ½ÌÖ°¹¤Éç»á±£ÏÕ¡¢×¡·¿¹«»ý½ðµÈ´ýÓö£»ÏíÊÜÈ«¹ú²©¹Ü»á¹ØÓÚ³öÕ¾²©Ê¿ºó»§¿ÚÇ¨ÒÆ¼°¼ÒÊô»§¿ÚËæÇ¨µÈÕþ²ß£» 4£¬Ö§³Ö²©Ê¿ºó»ù½ðºÍ×ÔÈ»¿ÆÑ§»ù½ðÉêÇ룻¶Ô±íÏÖ³ö½ÏÇ¿¿ÆÑÐDZÁ¦²¢ÓÐÒâ¼ÌÐø´ÓÊ¿ÆÑй¤×÷µÄ²©Ê¿ºó£¬¹Ø×¢²¢»ý¼«ÐÖúÆä¿ÆÑÐÖ°Òµ·¢Õ¹ºÍ¹æ»®¡£ ÉêÇ뷽ʽ Ç뽫Ïà¹Øµç×Ó°æpdfÉêÇë²ÄÁÏ·¢ËÍÖÁlingchu@mail.tsinghua.edu.cn¡£Óʼþ±êÌâÇë×¢Ã÷¡°Ó¦Æ¸²©Ê¿ºó+ÐÕÃû¡±¡£ºÏÊÊÕߣ¬½«¾¡¿ìÁªÏµ°²ÅÅÃæÊÔ£¬°ìÀí²©Ê¿ºó½øÕ¾ÊÖÐø»òÇ©¶©ÀͶ¯ºÏͬ¡£ ÕÐÆ¸Ê±ÏÞ ³¤ÆÚÓÐЧ ´ú±íÂÛÎÄ 1.W. Wang†, H. Guo†, X. Yan†, X. Pan, X. Wang, Y. Rong, Z. Bai, L. Zhang, Z. Wu, X. Zhao, W. Huang, W. Qin, and L. Chu* Silicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo. Nature Communications 2025, 16, 8134. 2.L. Tu†, H. Qin†, S. Luo, X. Liu, R. Zhao, X. Ding, S. Zhang, L. Chu* Ligand-induced Self-Complementing tag (LiSC-tag) as an epitope tag for live-cell super-resolution imaging and functional manipulation of cellular proteins. J. Am. Chem. Soc. 2025, 147, 36210-36222. 3.X. Yan, J.-H. Zhao, Q. Wang, W. Wang, Y. Ding, Y. Zhou, G. Chen, J. Du, W. Huang, L. Chu* Silicon Rhodamine-Catalyzed Near-Infrared Light-Induced Photodecaging of Ortho-Nitrobenzyl Groups In Vitro and In Vivo. J. Am. Chem. Soc. 2025, 147, 20957-20966. 4.X. Sun, Y. Zhang, W. Lu, H. Guo, G. He, S. Luo, H. Guo, Z. Zhang, W. Wang, L. Chu, X. Liu, W. Qin Precise and In Vivo-Compatible Spatial Proteomics via Bioluminescence-Triggered Photocatalytic Proximity Labeling. ACS Central Science 2025, 11, 1611-1626. 5.II. Ng, Z. Zhang, K. Xiao, M. Ye, T. Tian, Y. Zhu, Y. He, L. Chu, H. Tang Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway. Cell Reports 2025, 44, 115733. 6.T. Yang, J. He, X. Zhao, C. Ren, Z. Ding, L. Wang, H. Zhao, L. Chu, S. Luo, C. Shi, L. Gu, T. Xu, Ge Yang, W. Ji Self-adaptive fine-tuning of deep learning super-resolution microscopy for artifact suppression in live-cell imaging. The Innovation 2025, online now. 7.Q. Wang, Y. Song, S. Yuan, Y. Zhu, W. Wang and L. Chu* Prodrug activation by 4,4¡¯-bipyridine-mediated aromatic nitro reduction. Nature Communications 2024, 15, 8643. 8.Y. Wang, S. Luo, H. Su, Z. Wang*, L. Chu* and C. Zhang* BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson¡¯s disease. J. Biol. Chem. 2024, 300, 107543. 9.Y. Zhu†, X. Yan†, Y. Chi, B. Liu, W. Huang and L. Chu* Near-Infrared Light Controlled Protein Degradation by Photo-caged Lenalidomide and Pomalidomide. Bioorganic Chemistry 2024, 143, 107050. 10.Y. Hou , Z. Wang , P. Liu , X. Wei, Z. Zhang, S. Fan, L. Zhang, F. Han, Y. Song, L. Chu, C. Zhang* SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity 2023, 56, 2492-2507. 11.Z. Du, W. Wang, S. Luo, L. Zhang, S. Yuan, Y. Hei, Z. Bao, C. Chen, Y. Lin, and L. Chu* Self-Renewable Tag for Photostable Fluorescence Imaging of Proteins. J. Am. Chem. Soc. 2023, 145, 18968-18976. [ À´×Ô°æ¿éȺ ±±¾© ] |
» ²ÂÄãϲ»¶
²ÄÁÏ»¯¹¤340Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
Ò»Ö¾Ô¸ÏÃÃÅ´óѧ²ÄÁϹ¤³Ìר˶354ÕÒµ÷¼Á£¡£¡£¡
ÒѾÓÐ6È˻ظ´
271Çóµ÷¼Á
ÒѾÓÐ20È˻ظ´
Ò»Ö¾Ô¸085600ÖпÆÔºÄþ²¨Ëù276·ÖÇóµ÷¼Á
ÒѾÓÐ24È˻ظ´
Ò»Ö¾Ô¸±±½»´ó²ÄÁϹ¤³Ì×Ü·Ö358
ÒѾÓÐ4È˻ظ´
0856²ÄÁÏÓ뻯¹¤µ÷¼Á£¬339
ÒѾÓÐ11È˻ظ´
Ò»Ö¾Ô¸Ö£´ó²ÄÁϹ¤³Ì290Çóµ÷¼Á
ÒѾÓÐ19È˻ظ´
266·Ö£¬Ò»Ö¾Ô¸µçÆø¹¤³Ì£¬±¾¿Æ²ÄÁÏ£¬Çó²ÄÁÏרҵµ÷¼Á
ÒѾÓÐ9È˻ظ´
372·Ö²ÄÁÏÓ뻯¹¤£¨085600£©Ò»Ö¾Ô¸ºþÄÏ´óѧÇóµ÷¼Á
ÒѾÓÐ3È˻ظ´
Ò»Ö¾Ô¸ÄÏʦ´ó0703»¯Ñ§ 275Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´














»Ø¸´´ËÂ¥
10