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[交流] 中国科学院生物物理研究所方显杨研究组招聘科研助理

课题组简介：
   中国科学院生物物理研究所方显杨课题组聚焦于RNA整合结构生物学研究。课题组一方面致力于RNA高级结构研究新方法的开发及其在RNA高级结构、构象动态、相互作用与功能关系研究中的应用，另一方面致力于靶向RNA与基于RNA的生物疗法关键技术的开发。课题组近年来在利用非天然碱基系统发展长链RNA的位点特异性标记技术(PNAS 2020, Chem. Sci. 2020, Nat. Commun. (2021, 2023a, 2025), Biophys. J. 2022，ACS Chem. Biol. 2022, Nat. Biotechnol. 2025, )、以及应用相关技术开展RNA的高级结构、构象动态、相互作用与功能关系研究（EMBO Rep. 2019，Nat. Commun. 2020，Nat. Commun. 2021，EMBO J. 2021，Nat. Commun. (2020, 2021, 2023a, 2023b, 2024, 2025)，Nucleic Acids Res. 2023）方面取得了重要进展。
   课题组的具体研究方向可见：https://ibp.cas.cn/rc/fxy/202411/t20241108_7436395.html
   现因工作需要，拟招聘1-2名研究助理。

   一、岗位职责：
   1. 在PI和博士后的共同指导下，参与相关课题的研究工作；
   2. 协助课题组的相关组织管理工作。

   二、招聘要求：
   1. 生命科学或化学或基础医学相关专业，本科或以上学历；
   2. 熟练掌握基因克隆、蛋白质与RNA表达纯化等生物化学与分子生物学实验技术；
   3. 对科学研究具有强烈兴趣，踏实肯干，具有较强的动手能力，团队协作精神及责任心。

   三、岗位待遇：
      按照中科院生物物理所的相关规定，享受中科院生物理所合同聘用制（非事业单位编制）待遇，并根据个人背景提供额外补助，具体待遇面议。表现优秀者可推荐进一步深造（本科生推荐硕士研究生夏令营机会，硕士生推荐普博生机会）。

   四、招聘方式：
      应聘者请于2025年12月20日前将本人详细简历及可以开始工作的时间通过电子邮件发至:  fxy_ncrna@163.com, 并在邮件标题注明“应聘科研助理-本人姓名”。我们将统一安排面试时间。
五、课题组近期发表论文：
1. Xiaolin Niu#, Shanshan Cai#, Junzheng Wang, Chunlai Chen*, Xianyang Fang*. tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch. Nature Communications 2025, Accepted in press.
2. Meishuo Liu#, Keyun Huang#, Jie Zhang#, Qingyang Li, Xinming Wang, Buming Gu, Hao Tang, Zhenhai Du, LiangJun Hu, Shutao Qi, Yu Ma, Hongtao Yu, Wei Xie*, Xianyang Fang*, Haifeng Wang*. CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci. Nature Biotechnology 2025, doi: 10.1038/s41587-025-02887-3.
3. Jie Zhang, Xianyang Fang*. Empowering the molecular ruler techniques with unnatural base pair system to explore conformational dynamics of flaviviral RNAs. Current Opinion in Structural Biology 2024, 89: 102944.
4. Yufan Zhang# , Zhonghe Xu# , Yu Xiao# , Haodong Jiang# , Xiaobing Zuo , Xing Li*, Xianyang Fang*. Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nature Communications 2024, 15(1):4206
5. Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen*, Xianyang Fang*. Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch. Nature Communications 2023, 14(1):7394.
6. Xiang Chen#, Yan Wang#, Zhonghe Xu#, Meng-Li Cheng, Qing-Qing Ma, Rui-Ting Li, Zheng-Jian Wang, Hui Zhao, Xiaobing Zuo, Xiao-Feng Li, Xianyang Fang*, Cheng-Feng Qin*. Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1. Nature Communications 2023, 14(1): 1134
7. Lilei Xu#, Yu Xiao#, Jie Zhang, Xianyang Fang*. Structural insights into translation regulation by THF-II riboswitch. Nucleic Acids Research 2023, 51(2):952-965.
8. Xianyang Fang*, Jose Gallego*, Yun-Xing Wang*. Deriving RNA topological structure from SAXS. Methods in Enzymology 2022, 677:479-529.
9. Yanping Hu#, Yan Wang#, Jaideep Singh#，Ruirui Sun#, Lilei Xu, Xiaolin Niu, Keyun Huang, Guangcan Bai, Guoquan Liu, Xiaobing Zuo, Chunlai Chen, Peter Z. Qin, Xianyang Fang*. Phosphorothioate-based posttranscriptional site-specific labeling of large RNAs for structural and dynamic studies. ACS Chemical Biology 2022, 17(9):2448-2460
10. Burkhard Endeward#, Yanping Hu#, Guangcan Bai, Guoquan Liu, Thomas F. Prisner*, Xianyang Fang*. Long-range distance determination in fully deuterated RNA with pulsed EPR spectroscopy. Biophysical Journal 2022，121(1):37-43.
11. Xiaolin Niu#, Ruirui Sun#, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen*, Xianyang Fang*. Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs. Nature Communications 2021, 12(1): 6417
12. Junfeng Ma, Xiang Cheng, Zhonghe Xu, Yikan Zhang, Jaione Valle, Shilong Fan, Xiaobing Zuo, Inigo Lasa, Xianyang Fang*. Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch. The EMBO Journal 2021, 40(14): e107500. (Research Highlight on Nature Chemical Biology 2021, 17: 839)
13. Xiaolin Niu#, Qiuhan Liu#, Zhonghe Xu#, Zhifeng Chen, Linghui Xu, Lilei Xu, Jinghong Li*, Xianyang Fang*. Molecular mechanisms underlying the mechanical anisotropy of flaviviral exoribonuclease-resistant RNAs (xrRNAs). Nature Communications 2020, 11(1): 5496. (News and Views on Nature Chemical Biology 2021, 17: 933-934)
14. Yan Wang, Venkatesan Kathiresan, Yaoyi Chen, Yanping Hu, Wei Jiang, Guangcan Bai, Guoquan Liu, Peter Z. Qin*, Xianyang Fang*. Posttranscriptional site-directed spin labeling of large RNAs with an unnatural base pair system under non-denaturing conditions. Chemical Science 2020, 11: 9655-9664.
15. Yan Wang, Yaoyi Chen, Yanping Hu, Xianyang Fang*. Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription. Proceedings of the National Academy of Sciences 2020, 117(37): 22823-22832.
16. Yupeng Zhang#, Yikan Zhang#, Zhong-Yu Liu#，Meng-Li Cheng#, Junfeng Ma, Yan Wang, Cheng-Feng Qin*, Xianyang Fang*. Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Reports 2019, 20(11): e47016.

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