| 查看: 6293 | 回复: 1 | ||
| 【悬赏金币】回答本帖问题，作者kingoddess将赠送您 10 个金币 | ||
kingoddess金虫 (正式写手)
|
[求助]
求一篇文献，信息不全
|
|
|
标题 Treatment of Osteopenia With Melatonin: Effects on BMD, Muscle Strength and Quality of Life 2012年 embase数据库 URL https://www.embase.com/search/re ... amp;amp;from=export https://clinicaltrials.gov/study/NCT01690000 |
回复此楼» 猜你喜欢
8月时间戳变的，举个手。玩一下，释放压力
已经有11人回复
-
影响面上的因素
已经有6人回复
-
一个有机合成实验室都需要哪些设备？
已经有11人回复
-
求各位大神看下
已经有23人回复
-
面上再次挂了，太难了，躺也躺不了，倦也卷不过，小学校之殇！
已经有30人回复
-
2027年申博
已经有4人回复
-
好消息？这个有何含义？？？
已经有10人回复
-
咨询面上基金
已经有4人回复
-
【2027博士申请】纳米药物递送方向
已经有4人回复
-
UV压敏胶开发
已经有7人回复
kingoddess
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 622.7
- 红花: 1
- 帖子: 419
- 在线: 104.8小时
- 虫号: 873754
- 注册: 2009-10-16
- 性别: MM
- 专业: 卫生毒理
| Abstract： Brief Summary The aim of the study is to assess the effect of melatonin treatment in patients with osteopenia on BMD, muscle function, quality of life and calcium homeostasis. Detailed Description Background: Melatonin is known for its regulation of circadian rhythm. The production falls with age, which explains why elderly may have disturbed sleep patterns. Laboratory study and animal experimental studies suggests that melatonin also may protect against bone loss through increased osteoblast- and inhibited osteoclast activity. However, so far human studies have not been performed. Design and patients: Double blinded randomised controlled study. Eighty post-menopausal women (aged 55-75) with osteopenia are randomized to receive 1mg, 3mg or placebo (daily - at night time) for 12 months. Methods and results: Effects of melatonin on BMD, bone- structure and mass will be assessed through DXA-scans, pQCT, and QCT. Quality of life, sleep, and activity level will be assessed though questionnaires. Calcium homeostasis will be analyzed through blood and urines samples. As safety parameters, balance and muscle function will also be performed. Conclusion: Expected improvements in BMD, quality of life and sleep. |
2楼2025-11-04 00:23:57