| 查看: 313 | 回复: 1 | ||
| 【悬赏金币】回答本帖问题，作者kingoddess将赠送您 10 个金币 | ||
kingoddess金虫 (正式写手)
|
[求助]
求一篇文献，信息不全
|
|
|
标题 Treatment of Osteopenia With Melatonin: Effects on BMD, Muscle Strength and Quality of Life 2012年 embase数据库 URL https://www.embase.com/search/re ... amp;amp;from=export https://clinicaltrials.gov/study/NCT01690000 |
回复此楼» 猜你喜欢
职称评审没过，求安慰
已经有41人回复
-
回收溶剂求助
已经有7人回复
-
硝基苯如何除去
已经有3人回复
-
A期刊撤稿
已经有4人回复
-
垃圾破二本职称评审标准
已经有17人回复
-
投稿Elsevier的Neoplasia杂志，到最后选publishing options时页面空白，不能完成投稿
已经有22人回复
-
EST投稿状态问题
已经有7人回复
-
毕业后当辅导员了，天天各种学生超烦
已经有4人回复
-
求助文献
已经有3人回复
-
三无产品还有机会吗
已经有6人回复
kingoddess
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 631.2
- 红花: 1
- 帖子: 418
- 在线: 104.4小时
- 虫号: 873754
- 注册: 2009-10-16
- 性别: MM
- 专业: 卫生毒理
| Abstract： Brief Summary The aim of the study is to assess the effect of melatonin treatment in patients with osteopenia on BMD, muscle function, quality of life and calcium homeostasis. Detailed Description Background: Melatonin is known for its regulation of circadian rhythm. The production falls with age, which explains why elderly may have disturbed sleep patterns. Laboratory study and animal experimental studies suggests that melatonin also may protect against bone loss through increased osteoblast- and inhibited osteoclast activity. However, so far human studies have not been performed. Design and patients: Double blinded randomised controlled study. Eighty post-menopausal women (aged 55-75) with osteopenia are randomized to receive 1mg, 3mg or placebo (daily - at night time) for 12 months. Methods and results: Effects of melatonin on BMD, bone- structure and mass will be assessed through DXA-scans, pQCT, and QCT. Quality of life, sleep, and activity level will be assessed though questionnaires. Calcium homeostasis will be analyzed through blood and urines samples. As safety parameters, balance and muscle function will also be performed. Conclusion: Expected improvements in BMD, quality of life and sleep. |
2楼2025-11-04 00:23:57