| 查看: 805 | 回复: 1 | ||
| 【悬赏金币】回答本帖问题，作者kingoddess将赠送您 10 个金币 | ||
kingoddess金虫 (正式写手)
|
[求助]
求一篇文献，信息不全
|
|
|
标题 Treatment of Osteopenia With Melatonin: Effects on BMD, Muscle Strength and Quality of Life 2012年 embase数据库 URL https://www.embase.com/search/re ... amp;amp;from=export https://clinicaltrials.gov/study/NCT01690000 |
回复此楼» 猜你喜欢
291分调剂
已经有9人回复
-
调剂求收留
已经有34人回复
-
291 求调剂
已经有38人回复
-
22408 312求调剂
已经有17人回复
-
一志愿华中农业071010，320求调剂
已经有6人回复
-
290调剂生物0860
已经有41人回复
-
291求调剂
已经有3人回复
-
211本科材料化工求调剂
已经有23人回复
-
山东省基金2026
已经有9人回复
-
药学求调剂
已经有13人回复
kingoddess
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 622.7
- 红花: 1
- 帖子: 419
- 在线: 104.8小时
- 虫号: 873754
- 注册: 2009-10-16
- 性别: MM
- 专业: 卫生毒理
| Abstract： Brief Summary The aim of the study is to assess the effect of melatonin treatment in patients with osteopenia on BMD, muscle function, quality of life and calcium homeostasis. Detailed Description Background: Melatonin is known for its regulation of circadian rhythm. The production falls with age, which explains why elderly may have disturbed sleep patterns. Laboratory study and animal experimental studies suggests that melatonin also may protect against bone loss through increased osteoblast- and inhibited osteoclast activity. However, so far human studies have not been performed. Design and patients: Double blinded randomised controlled study. Eighty post-menopausal women (aged 55-75) with osteopenia are randomized to receive 1mg, 3mg or placebo (daily - at night time) for 12 months. Methods and results: Effects of melatonin on BMD, bone- structure and mass will be assessed through DXA-scans, pQCT, and QCT. Quality of life, sleep, and activity level will be assessed though questionnaires. Calcium homeostasis will be analyzed through blood and urines samples. As safety parameters, balance and muscle function will also be performed. Conclusion: Expected improvements in BMD, quality of life and sleep. |
2楼2025-11-04 00:23:57
