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美国北卡罗莱纳大学教堂山分校 UNC Chapel Hill-Dr. Wonho Kim Lab招聘博后
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Postdoctoral Fellow – Epigenetics and Chromatin Biology, University of North Carolina at Chapel Hill The laboratory of Dr. Wonho Kim at the University of North Carolina at Chapel Hill is seeking a highly motivated postdoctoral fellow. Our new lab investigates how the genome is organized in 3D within the nucleus and how this spatial organization influences nuclear functions. Research topics include: 1. Molecular mechanisms by which the genome is folded within the nucleus. 2. Identification of nuclear factors that regulate genome folding and elucidation of their mechanisms. 3. Impact of genome folding on gene transcription, DNA replication, and DNA damage response. 4. Contributions of dysregulated genome folding to human disease. To address these questions, we use diverse approaches such as genomics (Hi-C, ChIP-seq), DNA-FISH, biochemical assays, and genetic screening. For more information, please visit our lab website: Https://sites.google.com/view/wonhokimlab/home Representative publications: BRD4 orchestrates genome folding to promote neural crest differentiation. Linares, Kim and Bolar et al. Nature Genetics, 2021. A Genetic Screen for Modifiers of Cohesin Clustering Identifies Regulators of Genome Folding. Kim et al. Under revision The Kim lab is supported by NIH R35 (MIRA) funding. What You’ll Do • Lead an independent project on the regulatory mechanisms of cohesin-mediated genome folding (primarily topics 1 and 2 above). • Design and execute rigorous experiments; analyze, interpret, and present findings; and prepare manuscripts under supervision. • Publish in peer-reviewed journals and present at conferences • Contribute to a supportive lab culture and mentor junior trainees What You Bring • PhD or MD/PhD (or near completion). • Strong motivation and excellent communication skills. • Research experience in epigenetics, chromatin biology or bioinformatics is preferred but not required (Dr. Kim also transitioned to a new research field during his training). Why Join Us • Direct mentorship from Dr. Kim to help you achieve your career goal. • Assess to state-of-the-art core facilities at UNC. • A collaborative environment that values innovation and scientific rigor. How to apply Interested candidates should send the following materials to wonhok@unc.edu 1. Cover letter describing your research experience, interests, and career goal. 2. CV including contact information for three references. About UNC-Chapel Hill A global higher education leader in innovative teaching, research and public service, the University of North Carolina at Chapel Hill consistently ranks as one of the nation’s top public universities and is among the top ten research universities in the nation for federal research expenditures as well as for federally funded social and behavioral sciences research and development. Here at Carolina, our highly skilled postdocs play a vital role in our research enterprise and towards our overall commitment to research excellence. Across many disciplines, postdocs contribute to the intellectual vitality of the University. They provide innovative ideas and perspectives, foster a stimulating research environment and advance knowledge within their fields. Postdocs are crucial members of our scientific research workforce, contributors to our research outputs and an important reason why Carolina is one of the leading public research institutions in the country. UNC-Chapel Hill offers postdocs comprehensive medical and vision coverage, paid leave, and benefits and services that support professional development and a healthy work/life balance. Chapel Hill regularly ranks as one of the best college towns and best places to live in the United States, a reputation guided by the diverse social, cultural, recreation and professional opportunities that span the campus and community.  |
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