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金币: 554.1
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[交流] 荷兰格罗宁根大学药物递送方向招CSC博士生

研究方向：抗肿瘤药物纳米递送系统联合肿瘤免疫治疗、新型药物递送系统、脑靶向药物递送系统

1. 导师简介：
Flávia Sousa, Tenure-Track Assistant Professor。Sousa 教授以第一作者或通讯作者身份在 Nature Reviews Materials、Advanced Drug Delivery Reviews、Journal of Controlled Release 等国际顶级期刊发表与肿瘤治疗相关的药物递送研究论文40余篇，累计总被引超过2500次，H因子达31。她在基于肿瘤治疗的纳米药物递送系统研究领域处于世界领先水平。被评为麻省理工科技创新35岁以下杰出青年，同时也是国际控释学会（Controlled Release Society）杰出青年科学家。她主持多项国家级及欧盟科研项目，包括瑞士国家科学基金会（SNSF）资助的 NCCR Bio-Inspired Materials 项目、Falling Walls 基金会女性科学家计划等，累计科研经费超过100万欧元。她曾获得包括玛丽·居里奖学金（Marie Skłodowska-Curie Fellowship）、国际控释学会杰出青年科学家奖在内的多项国际奖项。
此外Sousa 教授还被邀请参加TED演讲，分享她对推动社会平等且健康的科学文化的看法，视频链接为：https://www.youtube.com/watch?v=KkjQeSsb8_U

更多关于Flávia Sousa教授的信息，可查看她的主页介绍：https://research.rug.nl/en/persons/fl%C3%A1via-moreira-de-sousa，或者 https://www.flaviasousasci.com/

Flávia Sousa教授的邮箱为：flavia.sousa@rug.nl 感兴趣的同学可以和她联系。

2. 研究经历：
2024年7月 – 至今，Tenure-Track Assistant Professor，荷兰格罗宁根大学
2024年1月 – 2024年6月，访问高级研究员，瑞士日内瓦大学 / AGORA癌症研究中心
2022年7月 – 2024年6月，高级研究员

3. 代表性成果：
1. F. Haamedat, B. Mendes, J. Conniot, L. D. Di Filippo, M. Chorilli, A. Schroeder, J. Conde, F. Sousa*, Engineered nanomaterials for glioblastoma nanovaccination, Nat Rev Mat, 9, 628–642 (2024) (Featured on September COVER)
2. F. Sousa, Emerging cytokine delivery with nanomedicine for brain cancer treatment, Expert Opinion on Drug Delivery, 21 (4), 513-516 (2024)
3. F. Sousa*, H. Lee, M. Almeida, A. Bazzoni, B. B. Rother-Rutishauser, A. Petri-Fink, Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy, Drug Deliv Transl Res, 14 (10), 2655-2667, (2023)
4. F. Sousa, Brain-Targeted Drug Delivery, Pharmaceutics, 14(9), 1835, (2022)
5. F. Diniz, M. Azevedo, F. Sousa, H. Osório, D. Campos, P. Sampaio, J. Gomes, B. Sarmento, C. Reis, Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions, Materials Today Bio,16, 100417, (2022)
6. F. Sousa, A.I. Costa-Pereira, A. Cruz, F.J. Ferreira, M. Gouveira, J. Bessa, B. Sarrmento, R.D.M. Travasso, I.M. Pinto, Intratumoral VEGF nanotrapper reduces glioblastoma vascularization and tumor cell mass, J Control Release, 339, 381-390, (2021)
7. J.M.W.D. Neto, J.C. Silva, F. Sousa, O.S.L. Gonçalves, M.C. A. Wanderley, B. Sarmento, C.A. Lima, M.T. Neves-Petersen, A. L. F. Porto, Structural and functional analysis of broad pH and thermal stable protease from Penicilium aurantiogriseum URM 4622, Preparative Biochem & Biotech, (2021)
8. B. Sánchez-Dengra, I. González-Álvarez, F. Sousa, M. Bermejo, M. González-Álvarez, B. Sarmento, In vitro model for predictiong the access and distribution of drugs in the brain using hCMEC/D3 cells, Eur. J. Pharm. Biopharm, 163: 120-126, (2021)
9. J. Finbloom, F. Sousa, M. M. Stevens, T.A. Desai, Engineering the Drug Carrier Biointerface to Overcome Biological Barriers to Drug Delivery, Adv. Drug Deliv. Rev.,167: 89-108, (2020)
10. A. Jaradat, M.H. Macedo, F. Sousa, K. Arkill, C. Alexander, J. Aylott, B. Sarmento, Prediction of the enhanced absorption of insulin across triple co-cultured model using mucus penetrating PLGA NPs, Inter. J. Pharm., 585:119516, (2020)
11. A. Baião, F. Sousa, A. Oliveira, C. Oliveira, B. Sarmento, Effective intracelular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells, Biomaterials Science, 8:3720-3729, (2020)
12. J.P. Martins, J. das Neves, M. de la Fuente, C. Celia, H. Florindo, N. Günday-Türeli, A. Popat, J. L. Santos, F. Sousa, R. Schmid, J. Wolfram, B. Sarmento, H. Santos, The solid progress of nanomedicine, Drug Deliv. and Transl. Res., 10(3): 726-729, (2020)
13. M. Qin, J. Jin, Q. Saiding, Y. Xiang, Y. Wang, F. Sousa, B. Sarmento, W. cui, X. Chen, In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic flood repair, J. Controlled Release, 322, 375-389, (2020)
14. C. Pacheco, F. Sousa, B.Sarmento, Chitosan-based Nanomedicine for Brain Delivery: Where Are We Heading?, Reactive and Functional Polymers, Reactive and Functional Polymers, 146:104430, (2020)
15. J. Yang, F. Wang, Y. Lu, J. Qi, L. Deng, F. Sousa, B. Sarmento, Xiangyang Xua, Wenguo Cui, Recent advance of erythrocyte-mimicking nanovehicles: from bench to bedside, J. Control Release, 20; 314:81-91, (2019)
16. F. Sousa, H.K. Dhaliwal, F. Gattacceca, B. Sarmento, M. Amiji, Enhanced Anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles, J. Control Release, 22;309:37-47, (2019)
17. R.P. Moura, C. Martins, F. Sousa, S. Pinto, B. Sarmento, Blood-Brain Barrier receptors and transporters: An insight on their function and how to exploit them though nanotechnology, Expert Opinion on Drug Delivery, 16(3):271-285, (2019)
18. N.N. Ferreira, B.L. Caetano, F.I. Boni, F. Sousa, M. Magnani, B. Sarmento, B.S.F. Cury, M.P.D. Gremião, Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In vitro structural features and release properties, J. Pharm. Sciences, 108(4):1559-1658, (2019)
19. P. J. Kennedy, F. Sousa, D. Ferreira, C. Pereira, M. Nestor, C. Oliveira, P. L. Granja, B. Sarmento, Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6, Acta Biomater., 81:208-218, (2018)

4. 重要奖项：
2023年麻省理工科技评论评选“欧洲35岁以下创新者”
2023年荷兰特温特大学 TEDx 演讲者
2023年入选Falling Walls基金会“女性科学人才”项目
2022年《Pharmaceutics》期刊差旅奖
2021年玛丽·居里COFUND资助
2019年 COST行动计划CA15216差旅奖
2019年葡美基金会（FLAD）资助奖
2019年控释学会（Controlled Release Society）杰出青年科学家奖
2019年 SPLC-CRS会议最佳口头报告奖
2018年 COST行动计划CA17140纳米医学资助
2018年控释学会杰出青年科学家奖
2017年富布赖特奖学金获得者

5. 科研项目
2024年格罗宁根大学科研启动基金 – 650,000 欧元
2023年 NCCR仿生材料独立资助项目 – 4,000 瑞士法郎
2022年 NCCR仿生材料与瑞士国家科学基金会（SNSF）资助的女性科学家独立研究奖学金 – 245,000 瑞士法郎
2021年玛丽·居里博士后COFUND奖学金 – 100,000 欧元
2019年 FLAD（葡美基金会）资助 – 800 欧元
2018年富布赖特研究资助 – 15,000 欧元

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