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【求助】急求阿托伐他汀钙的美国质量标准！
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急求阿托伐他汀钙的美国质量标准！ CAS：134523-03-8 |
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求阿托伐他汀钙的美国质量标准
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karl2100(金币+1,VIP+0):3Q 12-17 21:50
karl2100(金币+1,VIP+0):3Q 12-17 21:50
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Monograph Number: 868 Title: Atorvastatin CAS Registry Number: 134523-00-5 CAS Name: (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid Molecular Formula: C33H35FN2O5 Molecular Weight: 558.64. Percent Composition: C 70.95%, H 6.31%, F 3.40%, N 5.01%, O 14.32% Literature References: HMG-CoA reductase inhibitor. Prepn: B. D. Roth, EP 409281; idem, US 5273995 (1991, 1993 both to Warner-Lambert); K. L. Baumann et al., Tetrahedron Letters 33, 2283 (1992). Solubility and kinetic studies: A. S. Kearney et al., Pharm. Res. 10, 1461 (1993). Clinical pharmacokinetics: D. D. Cilla, Jr. et al., Clin. Pharmacol. Ther. 60, 687 (1996). Review of clinical trials: R. G. Bakker-Arkema et al., Atherosclerosis 131, 17-23 (1997). Derivative Type: Calcium salt CAS Registry Number: 134523-03-8 Manufacturers' Codes: CI-981 Trademarks: Lipitor (Warner-Lambert); Sortis (Parke-Davis); Torvast (Pfizer); Totalip (Guidotti); Xarator (Parke-Davis) Molecular Formula: C66H68CaF2N4O10 Molecular Weight: 1155.36. Percent Composition: C 68.61%, H 5.93%, Ca 3.47%, F 3.29%, N 4.85%, O 13.85% Properties: [a]D -7.4?(c = 1 in DMSO). Optical Rotation: [a]D -7.4?(c = 1 in DMSO) Derivative Type: Sodium salt CAS Registry Number: 134523-01-6 Molecular Formula: C33H34FN2NaO5 Molecular Weight: 580.62. Percent Composition: C 68.26%, H 5.90%, F 3.27%, N 4.82%, Na 3.96%, O 13.78% Properties: pKa 4.46. Soly in water (30?: 20.4 mg/ml (pH 2.1); 1.23 mg/ml (pH 6.0). pKa: pKa 4.46 Derivative Type: Lactone CAS Registry Number: 125995-03-1 CAS Name: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide Molecular Formula: C33H33FN2O4 Molecular Weight: 540.62. Percent Composition: C 73.31%, H 6.15%, F 3.51%, N 5.18%, O 11.84% Properties: mp 159.2-160.7? [a]D +26.05?(c = 1 in chloroform). Melting point: mp 159.2-160.7° Optical Rotation: [a]D +26.05?(c = 1 in chloroform) Therap-Cat: Antihyperlipoproteinemic. |
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