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edwardwtfl木虫 (正式写手)
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[交流]
蛋白A是指什么啊？
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偶是个做生物的菜鸟，最近看的几篇文章上面都有“protein A”，在谷歌上也没有搜到，到底是一种特殊的表达方式，还是说仅仅是后者？谢谢！ [ Last edited by amisking on 2009-11-9 at 17:57 ] |
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nicknelson
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小木虫(金币+0.5):给个红包，谢谢回帖交流
1949stone(金币+2,VIP+0):很细致 谢谢 11-9 09:51
小木虫(金币+0.5):给个红包，谢谢回帖交流
1949stone(金币+2,VIP+0):很细致 谢谢 11-9 09:51
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Protein A is a 40-60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It binds proteins from many of mammalian species, most notably IgG’s. It binds with the Fc region of immunoglobulins through interaction with the heavy chain. The result of this type of interaction is that, in serum, the bacteria will bind IgG molecules in the wrong orientation (in relation to normal antibody function) on their surface which disrupts opsonization and phagocytosis. http://en.wikipedia.org/wiki/Protein_A |
2楼2009-11-09 09:07:49
十比
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3楼2009-11-09 10:35:12
edwardwtfl
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4楼2009-11-09 17:56:28
edwardwtfl
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5楼2009-11-09 17:57:01
nicknelson
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6楼2009-11-10 00:15:34
