密苏里大学(哥伦比亚主校区)化学与医学工程系的杨仲羽教授课题组目前正在招聘一位生物化学和生物物理(biochemistry and biophysics)的研究生及博士后。专注于开展穿膜蛋白(transmembrane protein)的表征，提纯，以及其与普通蛋白质及固有无序蛋白质(intrinsically disordered proteins)的相互作用方面的研究。有线粒体外膜TOM转位酶（translocases）工作经验及论文发表者给予优先考虑。此外，课题组也招聘或者材料科学及催化方向的研究生及博士后1-2名
工作环境：密苏里大学（Mizzou)是美国卡内基高等教育基金会R1，是美国大学协会AAU（美国大学协会）综合性大学之一，是密州的旗舰大学。Mizzou共有 20 个系所与学院，提供>250 种学士学位课程与重点课程. Mizzou的公共管理学院，农学院、以及新闻学院的学术成就享誉全球。该校为美国仅存的6所在一个校区里就涵盖了医学，兽医学，以及工程学。
https://baike.baidu.com/item/%E7 ... /4221399?fr=aladdin
薪酬：每年55，000-59，000美元之间取决于经验。在此基础上还将额外提供全套医疗保险津贴以及国内会议旅行津贴
工作时间：灵活，无需打卡。
生活环境： 密苏里州属于美国生活成本中下的州。学校基础设施完善。大学所在地哥伦比亚市风景秀丽，地理位置优厚。既享受小城的宁静安全，又可以享受大城市的便利（距离堪萨斯城和圣路易斯各2个小时车程。距离芝加哥以及孟菲斯在六小时车程范围内）。气候温和湿润。校园安全，人们友善，学风口碑良好。
杨仲羽教授课题组概况：课题组目前专注于蛋白质及生物大分子在受限环境下的行为表征包括蛋白质折叠，转位，以及结构和功能的关系。研究的受限环境包括天然蛋白质转运通道(protein conducting channels)，分子伴侣(molecular chaperones),和细胞器官(cellular organelles)以及人工合成的多孔材料。课题组还致力于开发基于蛋白质受限在多孔材料中的复合材料以及其在能源，环境，和医学中的应用。课题组目前享受多个美国国家自然基金的支持以及来自密苏里大学充足的的启动经费。课题组全力支持课题组成员绿卡的申请以及找工作。
申请者最低要求：持有生物化学、生物工程或生物物理等相关领域的博士学位。以第一作者在专业期刊上发表过论文。有线粒体外膜TOM转位酶（translocases）工作经验及论文发表者给予优先考虑。
申请者请将简历发送至 zhongyuyang.ucla@gmail.com
课题组最近的代表性文章：
P. Ray, D. Dutta, M. Confeld, L. Alhalhooly, A. Sedigh, K. Iduoku, G. M. Casanola-Martin, H. Pham-The, B. Rasulev, Y. Choi, Z. Yang, S. Mallik, M Quadir*, “Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes”, J. Mater. Chem. B (2024), accepted.
M. Lenertz, Q. Li, Z. Armstrong, A. Scheiwiller, G. Ni, J. Wang, L. Feng, A. MacRae, and Z. Yang*, “A Magnetic Multi-Enzyme@Metal-Organic Material (MOM) for Sustainable Biodegradation of Insoluble Biomass”, ACS. Appl. Mater. Interfaces. (2024), 16, 11617–11626.
Z. Armstrong,# A. MacRae,# Q. Li, M. Lenertz, K. Johnson, A. Scheiwiller, P. Shen, L. Feng, M. Quadir, and Z. Yang*, “Impact of Metal-Organic Framework (MOF) crystallinity on enzyme orientation and dynamics upon biomineralization”, ACS. Appl. Mater. Interfaces (2023), 15, 31, 38124–38131. https://doi.org/10.1021/acsami.3c07870
Q. Li, Z. Armstrong, A. MacRae, A. Ugrinov, L. Feng, B. Chen, Y. Huang, H. Li, Y. Pan, Z. Yang*, “Metal-Organic Materials (MOMs) Enhance Proteolytic Selectivity, Efficiency, and Reusability of Trypsin: A Time-Resolved Study on Proteolysis”, ACS Appl. Mater. Interfaces (2023), 15, 7, 8927–8936. https://doi.org/10.1021/acsami.2c19873
Y. Pan, Q. Li, W. Liu, Z. Armstrong, A. MacRae, L. Feng, C. McNeff, P. Zhao, H. Li, and Z. Yang*, “Unveiling the orientation and dynamics of enzymes in unstructured artificial compartments of Metal-Organic Frameworks (MOFs)”, Nanoscale (2023), 15, 2573-2577. DOI: 10.1039/D2NR06659A
D. Jordahl, Z. Armstrong, Q. Li, R. Gao, W. Liu, K. Johnson, W. Brown, A. Scheiwiller, L. Feng, A. Ugrinov, H. Mao, Y. Pan, and Z. Yang*, “Expanding the “library” of Metal-Organic Frameworks (MOFs) for enzyme biomineralization”, ACS Appl. Mater. Interfaces (2022), 14, 51619-51629. https://doi.org/10.1021/acsami.2c12998
K. A Gaffney, R. Guo, M. Bridges, S. Muhammednazaar, D. Chen, M. Kim, Z. Yang, A. L. Schilmiller, N. Faruk, X. Peng, A. D. Jones, K. H. Kim, L. Sun, W. Hubbell, T. Sosnick, and H. Hong*, "Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein", Proc. Natl. Acad. Sci. (2022), 119, e2109169119.
Q. Li, Y. Pan,* H. Li, M. Lenertz, K. Reed, D. Jordahl, T. Bjerke, A. Ugrinov, B. Chen,* and Z. Yang,* "Cascade/parallel biocatalysis via multi-enzyme encapsulation on Metal-Organic Materials for rapid and sustainable biomass degradation" ACS Appl. Mater. Interfaces (2021), 13, 43085–43093.
Y. Pan, X. Wang, H. Li, J. Ren, Y. Zhang, D. Jordahl, I. Schuster, J. Farmakes, H. Hong, Z. Yang*, and S. Ma,* "In situ monitoring the protein transfer into nanoscale channels", Cell Reports Physical Science, (2021), 2, 100576. DOI: https://doi.org/10.1016/j.xcrp.2021.100576.
Y. Pan, H. Li, M. Lenertz, Y. Han, A. Ugrinov, D. Kilin, B. Chen, and Z. Yang,* “One-pot synthesis of enzyme@Metal-Organic Materials (MOM) biocomposites for enzyme biocatalysis”, Green Chemistry, (2021), 23, 4466-4476.
Y. Pan, H. Li, Q. Li, M. Lenertz, X. Zhu, B. Chen, and Z. Yang,* “Site-directed spin labeling (SDSL) and Electron Paramagnetic Resonance (EPR) spectroscopy in heterogeneous biocatalysis: probing enzyme orientation and backbone dynamics under nanoscale confinement ”, Chem Catalysis, (2021), 1, 207-231, invited contribution.
Y. Pan, Q. Li, H. Li, J. Farmakes, A. Ugrinov, X. Zhu, Z. Lai, B. Chen, and Z. Yang,* “A general Ca-MOM platform with enhanced acid/base stability for enzyme biocatalysis”, Chem Catalysis, (2021), 1, 146-161.
Q. Li, Y. Pan, H. Li, L. Alhalhooly, Y. Li, B. Chen, Y. Choi, and Z. Yang*, “Size-tunable Metal-Organic Framework coated magnetic nanoparticles for enzyme encapsulation and large-substrate biocatalysis”, ACS Appl. Mater. Interfaces (2020), 12, 41794–41801.
Y. Pan, O. Zholobko, H. Li, J. Jin, J. Hu, B. Chen,* A. Voronov,* and Z. Yang*, Spatial distribution and solvent polarity-triggered release of polypeptide incorporated into invertible micellar assemblies”, ACS Appl. Mater. Interfaces (2020) 10, 12075-12082.
Q. Sun, Y. Pan, H. Li, J. Farmakes, B. Aguila, Z. Yang*, and S. Ma*, “Mapping out the degree of freedom of hosted enzymes in confined spatial environments”, Chem (2019) 5, 3184-3195.
Y. Pan, H. Li, J. Farmakes, F. Xiao, B. Chen, S. Ma, and Z. Yang*, “How do enzymes orient when trapped on Metal-Organic Framework (MOF) surfaces?”, J. Am. Chem. Soc. (2018) 140, 16032-16036.
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