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Benjamin_Lee新虫 (小有名气)
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About the Project Biological membranes are fundamental structures found in all living cells, forming protective barriers that regulate the exchange of molecules, including nutrients, ions, and gases. The transport of gases such as oxygen (O?), carbon dioxide (CO?), and nitrogen (N?) across these membranes is essential for cellular respiration, metabolism, and overall physiological function. The rapidly evolving field of microfluidics, which enables precise fluid manipulation on a microscopic scale, offers innovative tools like lab-on-a-chip technology to study gas transport, overcoming limitations of conventional methods and finding applications across industries from pharmaceuticals to drug delivery. The goal of this research is to understand how impaired gas transport and membrane dysfunction contribute to diseases like Alzheimer’s and ischaemic stroke, while the mechanisms governing gas diffusion remain poorly understood. The project aims to develop and optimise innovative strategies to control gas transport through biological membranes in a microfluidic environment. The candidate will design and fabricate microfluidic devices and characterise the flow interaction through state-of-the-art fluorescence microscopy methods. The project will investigate how membrane composition, particularly lipid and cholesterol balance, affects gas diffusion using engineered phospholipid liposomes and microfluidic techniques to uncover insights into vascular health, brain metabolism and potential therapies for neurodegenerative and cardiovascular diseases. There will be exposure to several experimental techniques for the synthesis and characterisation of functional microparticles and undertaking proof-of-concept studies to identify prospective applications of the developed microfluidic systems. You will be member of a vibrant research group with state-of-the-art microfabrication and high-resolution fluorescence imaging facilities and will receive full support and training for developing your research. During the project, the candidate will collaborate with multidisciplinary researchers from University College London and University of Manchester. Dates Deadline for candidate applications: 28th April 2025 Provisional Interview Date: May 2025 Start Date: 1st October 2025 Funding Notes A tax-free stipend will be paid at the standard?UKRI rate; ?20,780 in 2025/26. This is a fully funded studentship of 3.5 years for UK/Home students. Non-UK candidates are encouraged to apply but the funding will only cover the overseas tuition fee for three years and the applicant would need to self-fund their living cost. References 1. S.M. Theparambil et al., Nature, 2024, 632, 8023? 2. S.M. Theparambil et al., Nature Communications, 2020, 11.? 3. Singh et al., Physical Review Letters, 2020, 125, 248002.? 4. Singh et al., Langmuir, 2022, 38, 46. Please contact Naval Singh if you are interested: n.singh1@lancaster.ac.uk 发自小木虫IOS客户端 |
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