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yexuqing木虫之王 (文学泰斗)
太阳系系主任
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[交流]
A panoramic view of cell population dynamics in mammalian aging
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A panoramic view of cell population dynamics in mammalian aging 哺乳动物衰老过程中细胞种群动态的全景视图 ▲ 作者：ZEHAO ZHANG, CHLOE SCHAEFER, WEIRONG JIANG, ZIYU LU, JASPER LEE, ANDRAS SZIRAKI, ABDULRAOUF ABDULRAOUF, BRITTNEY WICK, MAXIMILIAN HAEUSSLER, AND JUNYUE CAO ▲链接： https://www.science.org/doi/10.1126/science.adn3949 ▲摘要： 衰老是一个复杂的过程，导致组织和细胞类型的功能变化。利用单核RNA测序，这些变化开始被记录在整个生物体的生命周期中。Zhang等人在一种常用的小鼠品系和两种免疫缺陷品系及其野生型对应品系中生成了跨越多个时间点的细胞图谱，并对这些时间点上细胞群体的变化和细胞类型内表达的变化进行了分类。 在研究免疫补体减少的作用时，作者发现，在缺乏这些成年淋巴细胞的情况下，某些肠上皮细胞数量增加。这项研究为研究衰老的研究人员提供了资源，特别是在免疫缺陷的背景下。 ▲ Abstract： Aging is a complex process that results in functional changes across tissues and cell types. These changes are beginning to be documented across organismal lifespans using single-nuclei RNA sequencing. Zhang et al. generated cell atlases across multiple time points in both a commonly used mouse strain and two immunodeficient strains and their wild-type counterparts, cataloging changes in cell populations and expression changes within cell types over these time points. Investigating the role of a diminished immune complement, the authors found that certain intestinal epithelial populations increased in the absence of these adult lymphocytes. This study provides a resource for researchers studying aging, particularly in the context of immunodeficiency. |
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