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法国国家科学研究中心/普瓦捷化学与材料研究所/低聚糖的表面活性剂的设计合成/博士后�
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项目简介:用于设计可再生表面活性剂的低聚糖合成。 博士后职位简介:这个为期一年的博士后职位由 IC2MP 和 SYENSQO 合作提供,旨在开发一种催化 反应,从天然多糖中生产生物基表面活性剂,用于家庭个人护理中的各种应用。 在先前工作的基 础上,IC2MP 的策略将包括多糖的催化控制解聚,以获得具有所需分子量的寡糖及其进一步的功 能化。将优先使用工业催化剂。催化反应将在高压釜中进行,并通过尺寸排阻色谱、NMR 和质谱 法进行监测。在这种情况下,该项目将受益于对 IC2MP 的 PLATINA 分析平台的访问。低聚糖的物 理化学性质及其生物降解性将由 SYENSQO 评估。 工作内容简介:该研究将从文献综述开始,以 (1) 评估此类反应最有效的工业催化剂,以及 (2) 确定与该研究相关的科学和技术挑战。然后,候选人将负责进行第一次催化测试。在初始 阶段,候选人将使用均相酸催化剂。此阶段旨在优化所有反应参数,如压力、温度、浓度、气氛 等。在第二阶段,候选人将专注于使用非均相催化剂。在这些研究任务中,将特别考虑反应选择 性、催化剂消耗、能耗和反应器生产率等性能标准,以指导研究。 IC2MP 和 SYENSQO 之间将定期举行远程或面对面的工作会议,以确保研究项目的顺利进行,并在 必要时调整初始目标。在研究结束时,候选人将制作一份报告提交给 SYENSQO。 期望技能: 拥有化学博士学位,候选人应具有应用于精细/有机化学的催化专业知识,并对分析 (SEC、HPLC、NMR、质谱)有浓厚的兴趣。有多糖或糖化学经验者优先。候选人还应该充满好奇 心、保持严谨的态度,并能够作为国际团队的一员工作。 关于我们: 普瓦捷环境与材料研究所 (IC2MP) 是法国国家科学研究中心 (CNRS) 和普瓦捷大学 (University of Poitiers) 的联合研究单位,专注于可持续反应/产物的设计 (https://ic2mp.labo.univ- poitiers.fr )。它是一个跨学科研究所,致力于 (1) 生态高效技术(催化、生物溶剂、可再生能 源、替代技术等)的开发,以及 (2) 生态系统中有机分子的转移和生物积累。IC2MP 有能力通 过提供从设计到环境影响的科学和技术解决方案,在全球范围内整合化合物转化过程的关键步骤 。 Syensqo 是一家科技公司,致力于开发突破性的解决方案,以改善我们的生活、工作、旅行和 娱乐方式。受 Ernest Solvay 于 1911 年发起的科学委员会的启发,我们汇集了伟大的思想,拥有 一支由 13,000 多名员工组成的多元化全球团队(https://www.syensqo.com/en/),不断突破科学和 创新的极限,造福我们的客户。我们的解决方案有助于为家庭、食品和消费品、飞机、汽车、电 池、智能设备和医疗保健应用中提供更安全、更清洁、更可持续的产品。我们的创新能力使我们 能够实现循环经济的雄心壮志,并探索推动人类进步的突破性技术。 联系人 : francois.jerome@univ-poitiers.fr (IC2MP) et; antoine.beuque@syensqo.com (SYENSQO) Synthesis of oligosaccharides for the design of renewable surfactants We are looking for: a one-year postdoc, in collaboration between IC2MP and SYENSQO, which aims to develop a catalytic reaction to produce bio-based surfactants from natural polysaccharides for various applications in Home Personal Care. We count on you for: Building on previous works, the strategy at IC2MP will consist of a catalytic controlled depolymerization of polysaccharides to obtain oligosaccharides with desired molecular weights and their further functionalization. Industrial catalysts will be preferentially used. The catalytic reactions will be carried out in autoclaves and monitored by size-exclusion chromatography, NMR, and mass spectrometry. In this context, the project will benefit from access to the PLATINA analysis platform belonging to IC2MP. The physicochemical properties of the oligosaccharides, as well as their biodegradability, will be evaluated by SYENSQO. The research will begin with a literature review to (1) assess the most effective industrial catalysts for this type of reaction and (2) identify the scientific and technological challenges associated with this research. The candidate will then be in charge of performing the first catalytic tests. Initially, homogeneous acid catalysts will be used. This phase aims to optimize all reaction parameters such as pressure, temperature, concentration, atmosphere, etc. In the second phase, the candidate will focus on using heterogeneous catalysts. Throughout these research tasks, performance criteria such as reaction selectivity, catalyst consumption, energy consumption, and reactor productivity will be particularly considered to guide the research.Regular working meetings between IC2MP and SYENSQO, either remotely or in person, will take place to ensure the smooth progress of the research project and, if necessary, adjust the initial objectives. At the end of the study, the candidate will produce a report to be submitted to SYENSQO. Expected skills: Holder of PhD in chemistry, the candidate should have expertise in catalysis applied to fine/organic chemistry and a strong interest in analysis (SEC, HPLC, NMR, mass spectrometry). Prior experience in polysaccharide or sugar chemistry would be an advantage. The candidate should also be curious, rigorous, and able to work as part of an international team. About us: The Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP) is a joint research unit between CNRS and the University of Poitiers, focusing on the design of sustainable reactions/products (https://ic2mp.labo.univ-poitiers.fr ). It is an interdisciplinary institute working (1) on the development of eco-efficient technologies (catalysis, bio-solvents, renewable energies, alternative technologies, etc.) and (2) on the transfer and bioaccumulation of organic molecules in ecosystems. IC2MP has the capacity to globally integrate the key steps of a chemical compound transformation process by providing scientific and technological solutions, from design to environmental implications. Syensqo is a science company developing groundbreaking solutions that enhance the way we live, work, travel, and play. Inspired by the scientific councils that Ernest Solvay initiated in 1911, we bring great minds together to push the limits of science and innovation for the benefit of our customers, with a diverse, global team of more than 13,000 associates (https://www.syensqo.com/en/). Our solutions contribute to safer, cleaner, and more sustainable products found in homes, food and consumer goods, planes, cars, batteries, smart devices, and healthcare applications. Our innovation power enables us to deliver on the ambition of a circular economy and explore breakthrough technologies that advance humanity.Contact : francois.jerome@univ-poitiers.fr (IC2MP)et; antoine.beuque@syensqo.com (SYENSQO) |
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