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2025年巴黎高科 - CSC合作公派读博项目 - 课题No.48
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2025年巴黎高科 - CSC合作公派读博项目 - 课题No.48 2025 巴黎高科 - CSC公派博士项目 （12月8日截止） 网申通道：https://paristech.kosmopolead.com/phd 申请攻略：https://paristech.fr/fr/paristech-csc-phd-program-how-apply 课题48详情: TITLE: DESIGN OF THERANOSTIC PEPTIDE-BASED MULTIFUNCTIONAL NANOVECTORS: FROM STRUCTURE TO BIOLOGICAL PROPERTIES Topic number : 2024_048 Field : Chemistry, Physical chemistry and Chemical Engineering - Life and Health Science and Technology Subfield: ParisTech School: Chimie ParisTech - PSL Research team : SEISAD Research team website: https://iclehs.fr/research/seisad/ Research lab: I-CLEHS - Institute of chemistry for life and health Lab location: Paris Lab website: https://iclehs.fr Contact point for this topic: anne.varenne@chimieparistech.psl.eu Advisor 1: Anne Varenne - anne.varenne@chimieparistech.psl.eu Advisor 2: Fanny d'Orlyé - fanny.dorlye@chimieparistech.psl.eu Advisor 3: Bich-Thuy Doan - bich-thuy.doan@chimieparistech.psl.eu Advisor 4: Short description of possible research topics for a PhD: To fight cancer, the development of new alternative therapeutic strategies, that limit the undesirable side effects of conventional chemotherapy, is a prerequisite. Nanomedicine is an emerging field relying on the development of nanosystems as vectors of active moieties or activators making possible the reduction of the latter drug toxicity while improving its circulation time and targeting efficiency in vivo. Among natural building blocks to design smart nanomaterials, short self- assembling peptides have drawn significant interest due to their simple structure, relative chemical and physical stability, diversity in sequences and feasibility to synthesize in large amounts. In this context, the PhD project presents an innovative approach to design and validate novel theranostic agents based on biocompatible multifunctional peptide- containing nanoformulations including imaging probes and model drugs. In line with previous work, the project will focus on the relation between precursor peptide structures and nanoformulation biological and imaging properties, for an efficient pre-screening of relevant nanosystems in view of biomedical applications. Required background of the student: Analytical and physical chemistry, nanosciences, some theorical knowledge in biochemistry and biomedical engineering are welcome. A list of (5 max.) representative publications of the group: (Related to the research topic) 1. L. Trapiella-Alfonso, G. Ramirez-Garcia, F. d’Orlyé, A. Varenne. Electrokinetic methodologies for the characterization of nanoparticles and the evaluation of their behaviour in biological systems. Tracs, Trends in Analytical Chemistry (2016) 84, 121-130. Invited review (DOI: 10.1016/j.trac.2016.04.022) 2. F. d’Orlyé, L. Trapiella-Alfonso, C. Lescot, M. Pinvidic, BT Doan, A. Varenne. Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications. Molecules (2021), 26(15), 458. DOI: 10.3390/molecules26154587) 3. F. Espinola-Portilla, F. d’Orlyé, L. Trapiella-Alfons, S. Gutierrez Granados, G. Ramirez-Garcia, A. Varenne. A deep understanding of the self-assembly and colloidal stability of light and pH dual responsive spiropyran random copolymer micelle-like nanoaggregates. Materials Today Communication (2022) vol 31, 103499 (DOI 10.1016/j.mtcomm.2022.103499) 4. F. Espinola-Portilla, F. d’Orlyé, L. Trapiella-Alfonso, S. Gutierrez- Granados, G. Ramirez-Garcia, A. Varenne. Rational Understanding of Loading and Release of Doxorubicin by UV-Light- and pH-Responsive Poly(NIPAM-co-SPMA) Micelle-like Aggregates. Molecular Pharmaceutics (2023) 20, 3 1490-1499 (DOI : 10.1021/acs.molpharmaceut.2c00690) 5. A. Am, ME Faccio, M. Pinvidic, E. Reygue, BT Doan, C. Lescot, L. Trapiella Alfonso, F. d’Orlyé, A. Varenne*. A methodological approach by capillary electrophoresis coupled to mass spectrometry via electrospray interface for the characterization of short synthetic peptides towards the conception of self-assembled nanotheranostic agents. J. Chromatogr. A. 2024, 1713, 464496. (DOI : 10.1016/j.chroma.2023.464496) |
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