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[资源] 【分享】Nature一篇Tumour-initiating cells: challenges and opportunities-anticanc

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

Bin-Bing S. Zhou*, Haiying Zhang‡, Marc Damelin*, Kenneth G. Geles*,
Justin C. Grindley* and Peter B. Dirks§

Abstract | The hypothesis that cancer is driven by tumour-initiating cells (popularly
known as cancer stem cells) has recently attracted a great deal of attention, owing to
the promise of a novel cellular target for the treatment of haematopoietic and solid
malignancies. Furthermore, it seems that tumour-initiating cells might be resistant to
many conventional cancer therapies, which might explain the limitations of these agents
in curing human malignancies. Although much work is still needed to identify and
characterize tumour-initiating cells, efforts are now being directed towards identifying
therapeutic strategies that could target these cells. This Review considers recent
advances in the cancer stem cell field, focusing on the challenges and opportunities
for anticancer drug discovery.
http://d.namipan.com/d/f6c63435cd63e3cf42f21b836efd94d323c04f8b14b10d00

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