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hbao2019

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虫号: 21284492

[交流] University of Virginia 诚招全奖博士后和博士研究生

University of Virginia 诚招全奖博士后和博士研究生
--protein engineering/structural biology/synthetic biology

The Bao research group focuses on the membrane biology of cell communication (Bao et al., 2016, NSMB; Bao et al., 2018, Nature; Zhang et al. 2021, Nat Commun; Xiong et al., 2022 Cell; Shin et al., 2024 Nano Let). Using a combination of biochemical reconstitution, cell biology and structural approaches, we seek to elucidate how membranes and membrane proteins regulate life and death. Based on the findings from our basic research, we are also interested in reprogramming membrane biology for therapeutic development against human disease. We strive to create a supportive environment that inspires learning, innovation, and passion for scientific discovery. People in the lab will have numerous opportunities to explore their own research interest.
We emphasize rigorous training and open communication, and work as a team to tackle fundamental challenges in membrane biology. The lab is located in the Membrane Biology Center at the University of Virginia, with ample access to well-equipped imaging, flow cytometry and cryogenic electron microscopy cores in the same building. In addition, we are extensively collaborating with experts at UVA and across US to explore the utility of our tools developed with the support from the prestigious NIH Director’s Innovator Award. With several incoming grants from NIH and UVA, we are looking for multiple highly motivated postdocs in the following areas:
1) Structural membrane biology using cryoEM/ET;
2) Molecular mechanisms of membrane damage and repair;
3) Computational protein and peptide design;
4) Programming protein degradation and cell death;
5) Immune engineering with mRNA lipid nanoparticles against infections and cardiovascular diseases.

Previous experiences in biochemistry, structural biology, protein design, animal models, nanomedicine or cell biology are preferred. Salary is commensurate with experience and expertise, ranging from 62K to 80K per year plus insurance and benefits. The University of Virginia is founded by the third president of US, Thomas Jefferson, in 1819 at Charlottesville, a beautiful college town close to Washington-DC and Virginia Beach, and one of the ten best places to live in US.

Applicants should send a cover letter and CV to Dr. Huan Bao via email (baoh@virginia.edu). Students interested in the lab need to apply through the BIMS PhD program. Exceptional candidates can join the lab through direct match. GREs are not required (optional).
Lab website: https://sites.google.com/view/baolab/

实验室专注于细胞通讯和交流的膜生物学 (Bao et al.，2016，NSMB；Bao et al., 2018，Nature；Zhang et al., 2021, Nat Commun；Xiong et al., 2022, Cell; Shin et al., 2024 Nano Let). 通过生化重组、细胞生物学和结构生物学等方法，我们致力于阐明膜蛋白如何介导分泌和细胞死亡。基于我们对于这些基础研究的发现，我们将重新编程膜生物学以开发针对人类疾病的治疗方法。我们努力创造一个激发学习、创新和对科学发现的热情的研究培养环境。实验室的成员将有许多机会探索他们自己的研究兴趣。

我们强调严格的培训和开放的沟通，团队协作以应对膜生物学中的研究挑战。实验室位于弗吉尼亚大学的膜生物学中心，该中心配备了设备齐全的成像、流式细胞仪和冷冻电子显微镜设施。得益于多项NIH和UVA的资助，我们已经同多个课题组展开了前沿科学问题的探索研究，期待对以下领域感兴趣的博士生和博士后加入实验室的研究工作：
1）结构膜生物学和冷冻电镜；
2）膜损伤和修复的分子机制；
3）计算机辅助蛋白和多肽设计；
4）蛋白质降解和死亡；
5）纳米免疫工程和核酸药物开发。

有生物化学，结构生物学，机器学习，蛋白质设计，纳米医学或细胞生物学方面的相关经验者优先考虑。博士后薪水与经验和专业知识相称，年薪范围为60,000到80,000美元，另有保险和福利。弗吉尼亚大学由美国第三任总统托马斯·杰斐逊于1819年在夏洛茨维尔市创办，这是一座美丽的大学城，靠近华盛顿特区和弗吉尼亚海滩，也是美国十大最佳居住地之一。

申请人应通过电子邮件将求职信和简历发送至：baoh@virginia.edu.
实验室网站：https://sites.google.com/view/baolab/.

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