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PNAS is a multidisciplinary journal that aims to publish high-impact research of general interest to the scientific community. Because we receive more than 18,000 submissions every year, incoming manuscripts undergo an initial evaluation by a member of the Editorial Board, who is also a member of the National Academy of Sciences, to determine whether the potential novelty, impact, and relevance in the broad scientific community merit further detailed technical review. In your case, our assessment is that your manuscript does not meet one or more of the principal aims of our journal and on this basis we expect that the likelihood that detailed review will lead to publication is low.
This decision is necessarily subjective and does not reflect an evaluation of the technical quality of your work or of its appropriateness for a more specialized audience.

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