| 查看: 193 | 回复: 2 | |||
| 当前主题已经存档。 | |||
ashan631铁虫 (小有名气)
|
[交流]
急求FEMS Microbiol Rev 文献一篇，不胜感激！
|
||
|
Title：The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria Authors: Sauer U, Eikmanns BJ Abstract: In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally entangled set of reactions that interconnects the major pathways of carbon metabolism and thus, is responsible for the distribution of the carbon flux among catabolism, anabolism and energy supply of the cell. While sugar catabolism proceeds mainly via oxidative or non-oxidative decarboxylation of pyruvate to acetyl-CoA, anaplerosis and the initial steps of gluconeogenesis are accomplished by C3- (PEP- and/or pyruvate-) carboxylation and C4- (oxaloacetate- and/or malate-) decarboxylation, respectively. In contrast to the relatively uniform central metabolic pathways in bacteria, the set of enzymes at the PEP-pyruvate-oxaloacetate node represents a surprising diversity of reactions. Variable combinations are used in different bacteria and the question of the significance of all these reactions for growth and for biotechnological fermentation processes arises. This review summarizes what is known about the enzymes and the metabolic fluxes at the PEP-pyruvate-oxaloacetate node in bacteria, with a particular focus on the C3-carboxylation and C4-decarboxylation reactions in Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum. We discuss the activities of the enzymes, their regulation and their specific contribution to growth under a given condition or to biotechnological metabolite production. The present knowledge unequivocally reveals the PEP-pyruvate-oxaloacetate nodes of bacteria to be a fascinating target of metabolic engineering in order to achieve optimized metabolite production. |
回复此楼» 猜你喜欢
欢迎发来filecode的Mz6后的代码验证其规律
已经有34人回复
-
澳大利亚 Murdoch University 全奖博士招生（3个名额）地质化工冶金领域
已经有78人回复
-
咱们一起用铁证分析2026国家社科基金中标与否
已经有12人回复
-
FileCode能看出啥？
已经有30人回复
-
我的国基提前知道中了，可是同事的操作让我实在接受不了，怎么会有这样的人
已经有15人回复
-
关于Filecode分析方法
已经有12人回复
-
小木虫上这么多卖论文的，真有人买论文么？感觉没必要啊
已经有10人回复
-
阿姨
已经有4人回复
-
一作与独作在应聘高校教师时区别大吗
已经有4人回复
-
静等基金结果
已经有21人回复
ashan631
铁虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2271.5
- 散金: 37
- 帖子: 111
- 在线: 52.2小时
- 虫号: 496449
- 注册: 2008-01-18
- 专业: 微生物生理与生物化学
2楼2009-10-21 16:10:46
ashan631
铁虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2271.5
- 散金: 37
- 帖子: 111
- 在线: 52.2小时
- 虫号: 496449
- 注册: 2008-01-18
- 专业: 微生物生理与生物化学
3楼2009-10-21 16:17:43
