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Ò»¡¢°ÙÓ© DNA¼ì²âȾÁÏ PUR-1¼ò½é ÔÚûÓкËËáµÄÇé¿öÏ£¬PUR-1»ù±¾²»·¢Ó«¹â¡£ÔÚ´æÔÚDNA»òRNAµÄÇé¿öÏ£¬ÆäÓ«¹âÏÔ×ÅÔöÇ¿¡£ÔÚ´æÔÚRNAµÄÇé¿öÏ£¬PUR-1ÔÚ〜478 nm´¦¾ßÓÐÓ«¹â£¬Ó«¹âÁ¿×Ó²úÂÊΪ〜40£¥¡£PUR-1ȾÁÏÔÚ488 nm´¦¿É¼¤·¢£¨ÔÚ460 nm´¦Óд󼤷¢£©£¬²¢ÇÒÔÚ´æÔÚºËËáµÄÇé¿öÏ·¢³ö470ÖÁ550 nmÖ®¼äµÄÓ«¹â£¬ÔÚ478 nm´¦¾ßÓдó·¢Éä¡£¸ÃȾÁÏ¿ÉÓëÁ÷ʽϸ°ûÒǽáºÏÓÃÓÚ·ÖÎöѪԴÐÔ¼ÄÉú³æ¸ÐȾ¡£ ¶þ¡¢°ÙÓ© DNA¼ì²âȾÁÏ PUR-1²ÎÊý ·Ö×ÓÁ¿ 437.30 ÈÜ ¼Á DMSO ´æ´¢Ìõ¼þ ÔÚ-15¡æÒÔϱ£´æ£¬±Ü¹â·À³± ±£ÖÊÆÚ 12¸öÔ ¼¤·¢²¨³¤(nm) 459 ·¢É䲨³¤(nm) 478 Èý¡¢°ÙÓ© DNA¼ì²âȾÁÏ PUR-1²Î¿¼ÎÄÏ× Activation of Mitochondrial Uncoupling Protein 4 and ATP-Sensitive Potassium Channel Cumulatively Decreases Superoxide Production in Insect Mitochondria Authors: Slocinska M, Rosinski G, Jarmuszkiewicz W. Journal: Protein Pept Lett (2016): 63 Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis Authors: Wu Y, Shamoto-Nagai M, Maruyama W, Osawa T, Naoi M. Journal: J Neural Transm (Vienna) (2016): 491 Mitochondrial disease-related mutations at the cytochrome b-iron-sulfur protein (ISP) interface: Molecular effects on the large-scale motion of ISP and superoxide generation studied in Rhodobacter capsulatus cytochrome bc1 Authors: Ekiert R, Borek A, Kuleta P, Czernek J, Osyczka A. Journal: Biochim Biophys Acta (2016): 1102 Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model Authors: Achour I, Arel-Dubeau AM, Renaud J, Legr and M, Attard E, Germain M, Martinoli MG. Journal: Int J Mol Sci (2016): 1293 Manganese-superoxide dismutase (Mn-SOD) overexpression is a common event in colorectal cancers with mitochondrial microsatellite instability Authors: Govatati S, Malempati S, Saradamma B, Divyamaanasa D, Naidu BP, Bramhachari PV, Narayana N, Shivaji S, Bhanoori M, Tamanam RR, Rao PS, Nallanchakravarthula V. Journal: Tumour Biol. (2016) Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex Authors: Goncalves RL, Bunik VI, Br and MD., undefined Journal: Free Radic Biol Med (2016): 247 A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury Authors: Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP. Journal: Cell Metab (2016): 254 Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells Authors: Ochi R, Dhagia V, Lakhkar A, Patel D, Wolin MS, Gupte SA. Journal: Am J Physiol Heart Circ Physiol (2016): H1118 Recombinant Mitochondrial Manganese Containing Superoxide Dismutase Protects Against Ochratoxin A-Induced Nephrotoxicity Authors: Ciarcia R, Damiano S, Squillacioti C, Mirabella N, Pagnini U, Florio A, Severino L, Capasso G, Borrelli A, Mancini A, Boffo S, Romano G, Giordano A, Florio S. Journal: J Cell Biochem (2016): 1352 Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy Authors: Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. Journal: Diabetes (2016): 255 |
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