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美国宾夕法尼亚法学费城儿童医院博士后招聘已有1人参与
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博士后职位介绍 宾夕法尼亚大学和费城儿童医院 免疫工程和转化免疫学 MA LAB (https://www.malabimmuneng.com/) 寻找有动力有想法的博士后研究员加入我们的创新实验室，开展前沿肿瘤免疫研究并设计新型生物材料、蛋白质和工程改造细胞的免疫疗法。 我们是一个高度跨学科的团队，致力于免疫学和工程学的结合。我们利用 1) 化学和生物材料工程来剖析和操纵免疫细胞与细胞和细胞与组织的信号传递，以增强细胞疗法并促进疫苗开发，2) 基因工程和合成免疫学来创造智能细胞，通过智能细胞整合多种信号用于细胞功能决策，3 ) 蛋白质工程，以开发安全有效的免疫调节蛋白质和纳米结构，优化体内传输、释放动力学并增强或赋予新的治疗功能。 我们有三个博士后研究员职位，研究重点如下： 1，用化学/生物材料进行免疫调节以提高移植耐受性（或治疗自身免疫性疾病，例如 T1D）。 2，开发新型纳米颗粒/生物材料的药物递送平台和疫苗以增强实体瘤的免疫疗法。 3，设计新一代细胞免疫疗法以靶向抗原异质性肿瘤。 所需的教育、经验和技能 候选人应具有生物医学科学、免疫学、生物工程或化学的博士学位和/或医学博士学位（或同等学历）。理想的候选人应高度独立、有上进心、具有很强的解决问题能力和逻辑思维能力，并具有团队合作和有效沟通的能力。鉴于我们项目的高度跨学科性质，候选人应精通以下至少两种技术：多色流式细胞仪和免疫细胞分析、荧光/共聚焦显微镜、HPLC、FPLC、、生物材料/纳米粒子、疫苗设计和合成（mRNA 或纳米颗粒）、化学合成/修饰/表征和纯化、小鼠疾病模型、合成生物学、CRISPR高通量筛选、深度测序和数据分析、重组蛋白生产/表征和纯化、病毒载体改造与优化。 我们研究团队的使命和文化 我们是一个敬业的科学团队，致力于开发和应用尖端技术来调节免疫系统以治疗癌症和自身免疫性疾病。我们团结一致，尽我们所能作为一个团队一起努力工作，并与其他项目的研究人员合作，为世界各地数以千计的癌症和自身免疫性疾病患者寻找急需的治疗方法。我们的实验室在工作场所拥抱多样性和平等。我们从拥有不同背景、生活方式和经历的成员中认识到我们团队的力量。我们有责任公平、平等地对待彼此，以创造尽可能好的环境，以实现我们作为研究人员和个人的目标。只要齐心协力，我们可以实现我们的终极目标！ 成功的申请人将受益于快速发展以及多元化的 UPenn/CHOP 研究中心、量身定制的职业发展指导、最先进的研究设施和优越的福利待遇。申请人应将他们的询问发送给马博士（Leyuan.Ma@pennmedicine.upenn.edu 和 Leyuan.Ma@gmail.com，请同时发送电子邮件至两个地址）连同简历、三位推荐人的联系方式和研究经验的简要总结和兴趣。很高兴回答问题，请随时给我发电子邮件。 Job description The MA LAB for immune engineering and translational immunology at the University of Pennsylvania and Children’s Hospital of Philadelphia (https://www.malabimmuneng.com/) is seeking motivated post-doctoral fellows to join our innovative laboratory to carry out cutting-edge research on immune system crosstalk and engineer innovative biomaterials, protein and cell-based immunotherapies. We are a highly interdisciplinary team working at the interface of immunology and engineering. We leverage 1) Chemical and biomaterials engineering to dissect and manipulate immune cell-cell and cell-tissue crosstalk to enhance cellular therapy and promote vaccine development, 2) Genetic engineering and synthetic immunology to create intelligent cells that integrate environmental cues for decision making, 3) Protein engineering to develop safe and potent immune-modulatory proteins and nanostructures with desired trafficking profile, release kinetics, enhanced or novel functions. We have three postdoc fellow positions available with the following research focus: 1, Tailored immune modulation with chemistry/biomaterials to improve transplantation tolerance (and/or treatment of autoimmune diseases, e.g., T1D). 2, Development novel nanoparticle/biomaterials-based drug delivery platform and vaccines to enhance immunotherapies in solid tumors. 3, Engineering the next generation cellular immunotherapy to target antigenically heterogeneous tumors. Required Education, Experience, and Skills Candidates should have a PhD and/or MD (or equivalent) degree in biomedical sciences, immunology, bioengineering, or chemistry. Ideal candidates will be highly independent, self-motivated, possess strong problem solving and critical thinking skills and have the ability to work in a team, exercise discretion and communicate effectively. Given the highly interdisciplinary nature of our projects, candidates are expected to be expert and technically proficient in at least two of the following topics: multi-color flow cytometry and immune cell profiling, florescent/confocal microscopy, HPLC, FPLC, biomaterials/nanoparticles, vaccine designs and synthesis (mRNA or nanoparticles), chemical synthesis/modifications/characterizations and purifications, mouse disease models, synthetic biology and genetic circuit designs, CRISPR high-throughput screening, deep-sequencing and data analysis, recombinant protein production/characterization and purification, viral vector design and engineering. Our mission and culture We are a team of dedicated scientists developing and applying cutting edge technologies to modulate the immune system to treat cancer and autoimmune diseases. We are united in our mission to work as hard as we can, together as a team, and collaboratively with investigators in other programs, to find those treatments that are desperately needed for thousands of patients suffering from cancer and autoimmune disease around the world. Our lab embraces diversity and equality in the workplace. We recognize the strength of our team from including members with different backgrounds, ways of life, and experiences. We hold ourselves accountable for treating each other fairly and equally to create the best possible environment to succeed with our goals as researchers and individuals. Together, we can make a difference! Successful candidates will benefit from the thriving and collegial UPenn/CHOP research community, tailored career development guidance, state-of-the-art research facilities and excellent benefits package. Applicants should send their inquiries to Dr. Ma (Leyuan.Ma@pennmedicine.upenn.edu and Leyuan.Ma@gmail.com , please email to BOTH addresses) along with a CV, contacts for three references and a brief summary of research experience and interests. Happy to answer questions, feel free to email me. |
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