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香港大学李嘉诚医学院招全职博后-生物医学/干细胞/机械传感/再生医学/单细胞
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香港大学李嘉诚医学院 生物医学学院 谢赏恩教授 招聘1-2名全职博后 Kathryn Cheah教授为香港科学院成员、世界科学院院士，是一位发育遗传学家。于英国剑桥大学获得分子生物学博士学位，曾在英国曼彻斯特大学和帝国癌症研究基金会从事博士后研究。 在香港大学，她曾担任生物化学系主任和生殖、发育与生长中心主任。 由于对基质生物学的贡献，她被授予英国基质生物学学会奖章讲座 2022。 随着全球人口老龄化，基因组和再生医学将在帮助保持健康成长和生活质量方面发挥关键作用。她使用人类和小鼠胚胎干细胞和转基因小鼠作为模型来研究发育和疾病，并开发治疗软骨疾病（例如骨关节炎）和低骨量（例如骨质疏松症）和椎间盘退变的方法。在国际上，她是eLife 的高级编辑，还担任骨科研究杂志编辑委员会的编辑顾问。 更多具体介绍请参见PI主页：https://www.sbms.hku.hk/staff/kathryn-song-eng-cheah Post-doctoral Fellow on Mechanotransduction in Stem Cell Biology in the School of Biomedical Sciences, HKU Applications are invited for appointment as a Postdoctoral Fellow in the School of Biomedical Sciences, to commence as soon as possible for one or two years, with the possibility of renewal. Applicants should have a Ph.D. degree, preferably in Biology, Biomedical Sciences, Medical Engineering, or a related discipline. Experience in cell and molecular biology would be preferred. Applicants should also be organized, self-motivated, committed to the project schedule, and able to work independently and in a team. The appointee will participate in a multidisciplinary RGC-funded Collaborative Research Fund (CRF) project (see below) relating to the influence of the extracellular matrix on lineage-directed differentiation of human embryonic stem cells to intervertebral disc stem cells. For further information, please get in touch with Professor Kathryn Cheah (kathycheah@hku.hk) or Dr. Cheng-Han Yu (chyu1@hku.hk). The appointee will gain experience in stem cell biology, functional genomics, and single-cell biology. A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits. Project: Analyses of progenitors and differentiation trajectories in the nucleus pulposus and their relevance in intervertebral disc degeneration Intervertebral disc disease (IDD) and associated low back pain is an aging disorder of significant clinical burden. A likely disease-causing mechanism of IDD is the impairment of the reparative capacity of the intervertebral disc (IVD) tissues in the spine. The nucleus pulposus (NP) forms the central hydrated gelatinous core of the IVD. In IDD, the NP\'s mechanical strength and shock-absorbing capacity in the disc declines. But there is limited knowledge of the influence of the extracellular environment on the molecular characteristics and function of these cells in maintaining a healthy disc. In this project, we aim to study the role of extracellular matrix stiffness and mechanotransduction in NP cell differentiation and fate. Mechanical loading of the IVD is a crucial factor inducing cellular stress, matrix stiffening, and fibrosis that contribute to disc degeneration. Stiffened microenvironment can promote cell differentiation, proliferation, and expression of adhesion and ECM proteins. We will determine the impact of altering matrix stiffness after culturing in the stiffness-defined functionalized matrices on the differentiation of human embryonic stem cells to NP cells and their transcriptome and gene regulatory network. The insights will be linked and applied to the ongoing meta-analyses of genomic data on IDD. |
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