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树在田野

金虫 (小有名气)

应助: 1 (幼儿园)
金币: 806.6
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帖子: 96
在线: 69.1小时
虫号: 1135709
注册: 2010-10-31
性别: MM
专业: 疫苗学

[交流] 厦门大学疫苗与结构生物学组招生（面向公共卫生、生物背景招生）

厦门大学疫苗与结构生物学组招生（面向公共卫生、生物背景招生）
https://nidvd.xmu.edu.cn/info/1102/1072.htm
有意向请发简历联系
litingtingmu@163.com

ps：学科代码08开头，1004或1053才可调剂

（一）本组简介
人员构成：教师3人、高级工程师1人、博士后2人、学生32人、技术员6人，实习生1人，共44人。
研究方向：基因工程疫苗研究与开发、重要传染病病毒免疫表位的结构和功能研究、基于结构的分子模拟和分子设计、生物大分子药物质量分析与制剂研究、新型疫苗佐剂研发。
技术平台：基因工程疫苗研发平台、基于crispr-cas9技术的大肠杆菌基因组改造、杆状病毒表达系统、哺乳动物细胞表达系统、x-ray衍射晶体结构解析平台、cryo-em结构解析平台、分子动力学计算平台、二代测序平台、生物大分子药物质量分析平台、佐剂研发平台。
研究内容：
1. hpv系列：基于结构的人乳头瘤病毒（hpv）型交叉疫苗研发、hpv抗体中和机制研究、hpv免疫机制研究、hpv主要衣壳蛋白l1和次要衣壳蛋白l2相互作用研究、l2蛋白结构研究和hpv受体研究。
2. hev系列：戊型肝炎病毒（hev）广谱中和抗体和型特异抗体表位及机制研究；基于hev结构设计的通用的颗粒化疫苗研究。
3. vzv系列：基于水痘-带状疱疹病毒表面糖蛋白ge的重组疫苗研发与结构解析研究。
4. 新冠、肠道病毒、轮状病毒的结构研究：解析新冠病毒刺突蛋白spike、肠道病毒多种衣壳形式和轮状病毒与中和抗体复合结构，研究抗体介导的病毒中和作用机制、以及基于结构的中和抗体的广谱作用研究。
5. hiv系列：基于hiv-1包膜蛋白的免疫原设计及抗原免疫原性、广谱性的探索；hiv-1全长膜蛋白的提取及结构研究。
6. 疫苗质量控制：重组疫苗相关质量分析方法的建立（生物物理、生物化学、免疫化学方法）、重组疫苗体外相对效力分析、生物药物后期转化。
7. 新型佐剂：脂质体佐剂及乳剂型佐剂研发；基于氨基酸的无机佐剂研发；佐剂免疫调节机制研究。
（二）导师
李少伟，博士，教授，shaowei@xmu.edu.cn
俞海，博士，副教授，yuhai@xmu.edu.cn
顾颖，博士，副教授，guying@xmu.edu.cn
（三）正在开展的项目
1. hev/hpv多价联合疫苗研究与产品开发
2. hpv次要衣壳蛋白l2结构和功能研究以及hpv感染机制研究
  3. 肠道病毒广谱（交叉）中和抗体的结构基础
  4. 新冠病毒广谱中和抗体的结构基础
  5. 带状疱疹疫苗研究及相关蛋白结构解析
  6. 基于结构的流感ha关键表位研究
  7. hiv-1新型免疫原的分子设计及其广谱中和免疫原性的研究
  8. 基因工程疫苗研发和生产用的大肠杆菌表达系统的基因组功能改造和应用
  9. 脂质体/乳剂型佐剂制备、配方优化及佐剂质控方法的建立；佐剂安全性、有效性评估平台的建立
  10. 新冠重组疫苗体外相对效力实验及制剂稳定性研究
  11. 重组疫苗/蛋白（hpv九价疫苗、hpv二十价疫苗、水痘-带状疱疹疫苗）质量分析方法的建立
  12. 蛋白设计：定向展示表位的新型免疫原的从头设计，及靶向病原体特定位点的小分子蛋白抑制剂的从头设计研究
13. 分子动力学模拟：基于经典力学的计算模拟生物分子在溶液中的动态运动轨迹，辅助探究生物分子的物化特性（相互作用力）或生物过程发生的途径（构象变化，分子转运等）

（四）近5年来发表的部分文章
1. longfa xu#, qingbing zheng#, rui zhu#, zhichao yin#, hai yu#, yu lin, yuanyuan wu, maozhou he, yang huang, yichao jiang, hui sun, zhenghui zha, hongwei yang, qiongzi huang, dongqing zhang, zhenqin chen, xiangzhong ye, jinle han, lisheng yang, che liu, yuqiong que, mujin fang, ying gu, jun zhang, wenxin luo, z. hong zhou*, shaowei li*, tong cheng*, ningshao xia*. cryo-em structures reveal basis of receptor-initiated coxsackievirus uncoating with implications for therapeutic antibody development. cell host microbe, 2021, s1931-3128(21)00001-9. if=21.023
2. li t#, xue w#, zheng q#, song s#, yang c#, xiong h#, zhang s, hong m, zhang y, yu h, zhang y, sun h, huang y, deng t, chi x, li j, wang s, zhou l, chen t, wang y, cheng t, zhang t, yuan q, zhao q, zhang j, mclellan js, zhou zh*, zhang z*, li s*, gu y*, xia n*. cross-neutralizing antibodies bind a sars-cov-2 cryptic site and resist circulating variants. nature communications. 2021;12(1). if=14.919
3. wu y, huang x, yuan l, wang s, zhang y, xiong h, chen r, ma j, qi r, nie m, xu j, zhang z, chen l, wei m, zhou m, cai m, shi y, zhang l, yu h, hong j, wang z, hong y, yue m, li z, chen d, zheng q, li s, chen y, cheng t, zhang j, zhang t, zhu h, zhao q, yuan q, guan y, xia n. a recombinant spike protein subunit vaccine confers protective immunity against sars-cov-2 infection and transmission in hamsters. sci transl med. 2021;13(606). if=17.956
4. maozhou he#, xin chi#, zhenghui zha#, yunbing li, jie chen, yang huang, shiwen huang, miao yu, zhiping wang, shuo song, xinlin liu, shuangping wei, zekai li, tingting li, ying-bin wang, hai yu, qinjian zhao, jun zhang, qing-bing zheng*, ying gu*, shaowei li*, and ning-shao xia; structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding. journal of virology, 2021, 01587-20. if=5.103
5. zhang x, zhang z, xia n, zhao q*. carbohydrate-containing nanoparticles as vaccine adjuvants. expert review of vaccines. 2021. if=5.217
6. wang k#, zhou l#, chen t#, li q, li j, liu l, li y, sun j, li t, wang y, kong z, zheng q, zhang j, yu h, gu y*, xia n, li s*. engineering for an hpv 9-valent vaccine candidate using genomic constitutive over-expression and low lipopolysaccharide levels in escherichia coli cells. microbial cell factories. 2021;20(1). if=5.328
7. he, maozhou#; xu, longfa#; zheng, qingbing#; zhu, rui#; yin, zhichao#; zha, zhenghui; lin, yu; yang, lisheng; huang, yang; ye, xiangzhong; li, shuxuan; hou, wangheng; wu, yangtao; han, jinle; liu, dongxiao; li, zekai; chen, zhenqin; yu, hai; que, yuqiong; wang, yingbin; yan, xiaodong; zhang, jun; gu, ying; zhou, z. hong*; cheng, tong*; li, shaowei*; xia, ningshao*; identification of antibodies with non-overlapping neutralization sites that target coxsackievirus a16, cell host & microbe, 2020, 27(2): 249-261. if=21.023
8. daning wang#; xinlin liu#; minxi wei#;ciying qian; shuo song; jie chen; zhiping wang; qin xu; yurou yang; maozhou he; xin chi; shiwen huang; tingting li; zhibo kong; qingbing zheng; hai yu; yingbin wang; qinjian zhao; jun zhang; ningshao xia*;ying gu*& shaowei li*;rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles., nature communications, 2020, 11(1):2841. if=14.919
9. wei wang#;qingbing zheng#; dequan pan#; hai yu#; wenkun fu, jian liu, maozhou he, rui zhu, yuze cai, yang huang, zhenghui zha, zhenqin chen, xiangzhong ye, jinle han, yuqiong que, ting wu, jun zhang, shaowei li*;hua zhu*;z. hong zhou*;tong cheng*and ningshao xia*;near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. nature microbiology, 2020,5(12) :1542-1552. if=17.745
10. tingting li#; qingbing zheng#* ;hai yu#; dinghui wu#; wenhui xue#; hualong xiong#; xiaofen huang; meifeng nie; mingxi yue; rui rong; sibo zhang; yuyun zhang; yangtao wu; shaojuan wang; zhenghui zha; tingting chen; tingting deng; yingbin wang; tianying zhang; yixin chen; quan yuan*; qinjian zhao; jun zhang; ying gu*; shaowei li *and ningshao xia*; sars-cov-2 spike produced in insect cells elicits high neutralization titres in non-human primates, emerging microbes & infections, 2020; 9(1): 2076╟2090 if=7.163
11. weijin huang, maozhou he, tingting ning , jianhui nie, feng zhang, qingbing zheng, rui zhang, ying xu, ying gu, shaowei l, youchun wang;structural characterization of a neutralizing mab h16.001 that is qualified to a common potency assay for various hpv16 vaccines. npj vaccines,2020,5:89. if=7.344
12. ciying qian#; xinlin liu#; qin xu; zhiping wang; jie chen; tingting li; qingbing zheng ; hai yu ;ying gu*; shaowei li * and ningshao xia; recent progress on the versatility of virus-like particles.vaccines,2020, 20;8(1):139. if=4.422
13. qingbing zheng#; rui zhu#; longfa xu#; maozhou he#; xiaodong yan#; dongxiao liu; zhichao yin; yangtao wu; yongchao li; lisheng yang; wangheng hou; shuxuan li; zizhen li; zhenqin chen; zhihai li; hai yu; ying gu; jun zhang; timothy s baker; z hong zhou; barney s graham*; tong cheng*; shaowei li*; ningshao xia*; atomic structures of enterovirus d68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization , nature microbiology, 2019, 4(1): 124-133. if=17.745
14. kong r#, duan h#, sheng z#, xu k, acharya p#, chen x#, cheng c#, dingens as#, gorman j#, sastry m#, shen ch#, zhang b#, zhou t#, chuang gy, chao cw, gu y, jafari aj, louder mk, o'dell s, rowshan ap, viox eg, wang y, choi cw, corcoran mm, corrigan ar, dandey vp, eng et, geng h, foulds ke, guo y, kwon yd, lin b, liu k, mason rd, nason mc, ohr ty, ou l, rawi r, sarfo ek, schön a, todd jp, wang s, wei h, wu w; nisc comparative sequencing program, mullikin jc, bailer rt, doria-rose na, karlsson hedestam gb, scorpio dg, overbaugh j, bloom jd, carragher b, potter cs, shapiro l, kwong pd*, mascola jr*. antibody lineages with vaccine-induced antigen-binding hotspots develop broad hiv neutralization. cell. 2019 jul 25;178(3):567-584. if=38.812
15. zheng, qingbing#; jiang, jie#; he, maozhou#; zheng, zizheng#; yu, hai; li, tingting; xue, wenhui; tang, zimin; ying, dong; li, zekai; song, shuo; liu, xinlin; wang, kaihang; zhang, zhiqing; wang, daning; wang, yingbin; yan, xiaodong; zhao, qinjian; zhang, jun; gu, ying*; li, shaowei*; xia, ningshao*; viral neutralization by antibody-imposed physical disruption, proceedings of the national academy of sciences, 2019, 116(52): 26933-26940. if=11.205
16. chen, tingting#; wang, kaihang#; chi, xin; zhou, lizhi; li, jiajia; liu, liqin; zheng, qingbing; wang, yingbin; yu, hai; gu, ying; zhang, jun; li, shaowei*; xia, ningshao; construction of a bacterial surface display system based on outer membrane protein f , microbial cell factories, 2019, 18: 0-70. if=5.328
17. xinlin liu#; jie chen#; zhiping wang#; daning wang; maozhou he; ciying qian; shuo song; xin chi; zhibo kong; qingbing zheng; yingbin wang; hai yu; qinjian zhao; jun zhang; shaowei li*; ying gu*; ningshao xia; neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection, emerging microbes & infections, 2019, 8(1): 1721-1733. if=7.163
18. zhang z#, wei x#, lin y, huang f, shao j, qi j, deng t, li z, gao s, li s, yu h, zhao q, li s, gu y*, xia n. hiv-1 membrane-proximal external region fused to diphtheria toxin domain-a elicits 4e10-like antibodies in mice. immunol lett. 2019 jul 26. pii: s0165-2478(19)30005-7. if=3.171
19. li t#, zhang z#, zhang z#, qiao j, rong r, zhang y, yao q, li z, shen h, huang f, xue w, gao s, li s, zheng q, yu h, zhang j, gu y*, li s*, xia n. characterization of native-like hiv-1 gp140 glycoprotein expressed in insect cells. vaccine. 2019 mar 7;37(11):1418-1427. if=3.351
20. li zhihai#; song shuo#; he maozhou#; wang daning; shi jingjie; liu xinlin; li yunbing; chi xin; wei shuangping; yang yurou; wang zhiping; li jinjin; qian huilian; yu hai; zheng qingbing; yan xiaodong; zhao qinjian; zhang jun; gu ying*; li shaowei*; xia ningshao*; rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity., nature communications, 2018, 9(1): 0-5360. if=14.919
21. zhu rui#; xu longfa#; zheng qingbing#; cui yanxiang#; li shaowei#; he maozhou; yin zhichao; liu dongxiao; li shuxuan; li zizhen; chen zhenqin; yu hai; que yuqiong; liu che; kong zhibo; zhang jun; baker timothy s; yan xiaodong*; hong zhou z*; cheng tong*; xia ningshao*; discovery and structural characterization of a therapeutic antibody against coxsackievirus a10. science advances, 2018, 4(9): 0-eaat7459. if=14.143
22. wei minxi#; wang daning#; li zhihai#; song shuo; kong xianglin; mo xiaobing; yang yurou; he maozhou; li zhongyi; huang bo; lin zhijie; pan huirong; zheng qingbing; yu hai; gu ying; zhang jun; li shaowei*; xia ningshao*; n-terminal truncations on l1 proteins of human papillomaviruses promote their soluble expression in escherichia coli and self-assembly in vitro., emerg microbes infect, 2018, 7(1): 0-160. if=7.163
23. zhang z, zhang f, bai s, qiao j, shen h, huang f, gao s, li s, gu y*, xia n. characterization and epitope mapping of a panel of monoclonal antibodies against hiv-1 matrix protein. biotechnol appl biochem. 2018 nov;65(6):807-815. if=1.876
24. zhang z, wang l, bai s, qiao j, shen h, huang f, gao s, li s, li s, gu y*, xia n. expression, purification and characterization of hiv-1 capsid precursor protein p41. protein j. 2018 apr;37(2):194-202. if=1.572
25. li, zhihai#; wang, daning#; gu, ying#; song, shuo; he, maozhou; shi, jingjie; liu, xinlin; wei, shuangping; li, jinjin; yu, hai; zheng, qingbing; yan, xiaodong; baker, timothy s.; zhang, jun; mclellan, jason s.*; li, shaowei*; xia, ningshao*; crystal structures of two immune complexes identify determinants for viral infectivity and type-specific neutralization of human papillomavirus, mbio, 2017, 8(5). if=7.867
26. xu, longfa#; zheng, qingbing#; li, shaowei#; he, maozhou; wu, yangtao; li, yongchao; zhu, rui; yu, hai; hong, qiyang; jiang, jie; li, zizhen; li, shuxuan; zhao, huan; yang, lisheng; hou, wangheng; wang, wei; ye, xiangzhong; zhang, jun; baker, timothy s.; cheng, tong*; zhou, z. hong; yan, xiaodong*; xia, ningshao*; atomic structures of coxsackievirus a6 and its complex with a neutralizing antibody, nature communications, 2017, 11;8(1):505. if=14.919
（五）本组优势
我们组有众多研究平台，可满足各种科研需求，在疫苗设计、结构生物学、佐剂研发、生物信息等方面均有丰富的积累。组内以人为本，尊重学生的想法并给予支持，注重培养学生的科研思维和自主科研能力。欢迎广大学子进行咨询了解。

已招满。谢谢！

已招满。谢谢大家！

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