| 查看: 660 | 回复: 3 | |||
| 【悬赏金币】回答本帖问题，作者乞丐一样将赠送您 5 个金币 | |||
[求助]
求助各位大佬一篇付费文献
|
|||
|
Exenatide-loaded microsphere/ thermosensitive hydrogel long-acting delivery system with high drug bioactivity 作者:Wang, PX (Wang, Puxiu) [1] ; Zhuo, XZ (Zhuo, Xuezhi) [1] ; Chu, W (Chu, Wei) [1] ; Tang, X (Tang, Xing) [1] 卷528 期1-2 页62-75 DOI10.1016/j.ijpharm.2017.05.069 出版时间AUG 7 2017 已索引2017-08-07 文献类型Article 摘要 A series of mixed hydrogels of PLGA-PEG-PLGA and PCLA-PEG-PCLA were synthesized, and investigated in terms of their critical micelle concentration, stability and thermosensitive properties. Also, some mixed hydrogel was selected to prepare Depot-gel-in-Ms-in-Matrix-gel system for the treatment of type 2 diabetes mellitus. Briefly, Exenatide (EXT) loaded hydrogels was encapsulated in PLGA microspheres (Ms) and further encapsulated into blank hydrogel. The mechanism of Exenatide release involved drug diffusion, hydrogel diffusion, PLGA erosion and mixed hydrogel erosion. The results showed that EXT release in vitro was at a sustained rate for 46 days, because it is controlled by the inner-deport-gel, the Ms matrix and the outer-Matrix-gel successively. No burst release or platform was observed due to the interception function and control function of the outer-Matrix-gel. The biological activity of EXT was protected, because the hydrophilic EXT molecules tend to distribute in the hydrophilic domain of the mixed hydrogel. In vivo, a single injection of Depot-gel-in-Ms-in-Matrix-gel allowed mice to maintain a stable blood glucose concentration and well-controlled body weight for 20 days. In addition, results of oral glucose tolerance test and Hematoxylin-Eosin staining demonstrated that triple-barrier Depot-gelin-Ms-in-Matrix-gel was a promising hydrophilic protein/polypeptide-loaded long-acting system with high drug bioactivity. (C) 2017 Elsevier B.V. All rights reserved. 关键词 作者关键词ExenatidePeptideHydrogelPLGA microspheresPolymeric micelles Keywords PlusPCLA-PEG-PCLABIODEGRADABLE TRIBLOCK COPOLYMERTYPE-2 DIABETES-MELLITUSCONTROLLED-RELEASEPLGA MICROSPHERESMOLECULAR-WEIGHTPOLYMERIC NANOPARTICLESBIOMEDICAL APPLICATIONSDEGRADATION PROPERTIESINTRAVITREAL DELIVERY 作者信息 通讯作者地址 Tang, Xing (通讯作者) Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 地址 1 Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 电子邮件地址tanglab@126.com 类别/分类 研究方向Pharmacology & Pharmacy 引文主题 2 Chemistry 2.53 Polymers & Macromolecules 2.53.371 Hydrogels |
回复此楼» 猜你喜欢
急需审稿人！！！
已经有3人回复
-
申博/考博
已经有8人回复
-
一志愿A区211，22408 321求调剂
已经有8人回复
-
295分求调剂
已经有6人回复
-
一志愿中科大材料与化工，353分还有调剂学校吗
已经有13人回复
-
085600材料与化工调剂
已经有6人回复
-
期刊推荐
已经有5人回复
-
有没有接收比较快的sci期刊呀，最好在一个月之内的，研三孩子求毕业
已经有7人回复
-
又一批高校组建人工智能学院 师资行吗 不是骗人吗
已经有4人回复
-
337求调剂
已经有3人回复
zyqchem
木虫之王 (文学泰斗)
- PhEPI: 1
- 应助: 159 (高中生)
- 金币: 286497
- 红花: 554
- 沙发: 1964
- 帖子: 55251
- 在线: 11886.3小时
- 虫号: 3786654
- 注册: 2015-04-04
- 专业: 合成药物化学
2楼2023-02-24 21:16:50
3楼2023-02-25 15:29:07
zyqchem
木虫之王 (文学泰斗)
- PhEPI: 1
- 应助: 159 (高中生)
- 金币: 286497
- 红花: 554
- 沙发: 1964
- 帖子: 55251
- 在线: 11886.3小时
- 虫号: 3786654
- 注册: 2015-04-04
- 专业: 合成药物化学
4楼2023-02-25 15:57:46
5