| 查看: 655 | 回复: 3 | |||
| 【悬赏金币】回答本帖问题，作者乞丐一样将赠送您 5 个金币 | |||
[求助]
求助各位大佬一篇付费文献
|
|||
|
Exenatide-loaded microsphere/ thermosensitive hydrogel long-acting delivery system with high drug bioactivity 作者:Wang, PX (Wang, Puxiu) [1] ; Zhuo, XZ (Zhuo, Xuezhi) [1] ; Chu, W (Chu, Wei) [1] ; Tang, X (Tang, Xing) [1] 卷528 期1-2 页62-75 DOI10.1016/j.ijpharm.2017.05.069 出版时间AUG 7 2017 已索引2017-08-07 文献类型Article 摘要 A series of mixed hydrogels of PLGA-PEG-PLGA and PCLA-PEG-PCLA were synthesized, and investigated in terms of their critical micelle concentration, stability and thermosensitive properties. Also, some mixed hydrogel was selected to prepare Depot-gel-in-Ms-in-Matrix-gel system for the treatment of type 2 diabetes mellitus. Briefly, Exenatide (EXT) loaded hydrogels was encapsulated in PLGA microspheres (Ms) and further encapsulated into blank hydrogel. The mechanism of Exenatide release involved drug diffusion, hydrogel diffusion, PLGA erosion and mixed hydrogel erosion. The results showed that EXT release in vitro was at a sustained rate for 46 days, because it is controlled by the inner-deport-gel, the Ms matrix and the outer-Matrix-gel successively. No burst release or platform was observed due to the interception function and control function of the outer-Matrix-gel. The biological activity of EXT was protected, because the hydrophilic EXT molecules tend to distribute in the hydrophilic domain of the mixed hydrogel. In vivo, a single injection of Depot-gel-in-Ms-in-Matrix-gel allowed mice to maintain a stable blood glucose concentration and well-controlled body weight for 20 days. In addition, results of oral glucose tolerance test and Hematoxylin-Eosin staining demonstrated that triple-barrier Depot-gelin-Ms-in-Matrix-gel was a promising hydrophilic protein/polypeptide-loaded long-acting system with high drug bioactivity. (C) 2017 Elsevier B.V. All rights reserved. 关键词 作者关键词ExenatidePeptideHydrogelPLGA microspheresPolymeric micelles Keywords PlusPCLA-PEG-PCLABIODEGRADABLE TRIBLOCK COPOLYMERTYPE-2 DIABETES-MELLITUSCONTROLLED-RELEASEPLGA MICROSPHERESMOLECULAR-WEIGHTPOLYMERIC NANOPARTICLESBIOMEDICAL APPLICATIONSDEGRADATION PROPERTIESINTRAVITREAL DELIVERY 作者信息 通讯作者地址 Tang, Xing (通讯作者) Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 地址 1 Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 电子邮件地址tanglab@126.com 类别/分类 研究方向Pharmacology & Pharmacy 引文主题 2 Chemistry 2.53 Polymers & Macromolecules 2.53.371 Hydrogels |
回复此楼» 猜你喜欢
0854求调剂
已经有6人回复
-
求调剂推荐
已经有6人回复
-
材料299专硕求调剂
已经有17人回复
-
一志愿沪9，生物学326求调剂
已经有5人回复
-
294求调剂
已经有4人回复
-
297，工科调剂?河南农业大学本科
已经有11人回复
-
22专硕求调剂
已经有11人回复
-
284求调剂
已经有20人回复
-
291求调剂
已经有7人回复
-
296求调剂
已经有5人回复
zyqchem
木虫之王 (文学泰斗)
- PhEPI: 1
- 应助: 159 (高中生)
- 金币: 286278
- 红花: 553
- 沙发: 1964
- 帖子: 55219
- 在线: 11872小时
- 虫号: 3786654
- 注册: 2015-04-04
- 专业: 合成药物化学
2楼2023-02-24 21:16:50
3楼2023-02-25 15:29:07
zyqchem
木虫之王 (文学泰斗)
- PhEPI: 1
- 应助: 159 (高中生)
- 金币: 286278
- 红花: 553
- 沙发: 1964
- 帖子: 55219
- 在线: 11872小时
- 虫号: 3786654
- 注册: 2015-04-04
- 专业: 合成药物化学
4楼2023-02-25 15:57:46
