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jovi木虫 (小有名气)
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[交流]
【请教】CTAB的特性
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请问有用CTAB做模板合成多孔生物材料的吗？交流交流吧 搜索了几个，CTAB的熔点还有在水中的溶解度都不一样，也不知道信哪个，有知道详细特性的吗？多谢啦 |
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Detoxification of gold nanorods by treatment with polystyrenesulfonate Authors: Alexei P Leonov, Jiwen Zheng, Jeffrey D Clogston, Stephan T Stern, Anil K Patri, Alexander Wei Journal: ACS Nano We address an outstanding issue associated with the biocompatibility of gold nanorods (GNRs), a promising agent for biomedical imaging and theragnostics. GNRs are typically prepared in the presence of cetyltrimethylammonium bromide (CTAB), a cationic surfactant whose rigorous removal is necessary due to its cytotoxicity and membrane-compromising properties. CTAB-stabilized GNRs can be partially purified by treatment with polystyrenesulfonate (PSS), an anionic polyelectrolyte often used as a surrogate peptizing agent, followed by chloroform extraction and ultrafiltration with minimal loss of dispersion stability. However, in vitro cytotoxicity assays of PSS-coated GNRs revealed IC(50) values in the low to submicromolar range, with subsequent studies indicating the source of toxicity to be associated with a persistent PSS-CTAB complex. Further exchange of CTAB-laden PSS with fresh polyelectrolyte greatly improves biocompatibility, to the extent that 85 microg/mL of "CTAB-free" GNRs (the highest level evaluated) has comparable toxicity to a standard phosphate buffer solution. Ironically, PSS is not effective by itself at stabilizing GNRs in CTAB-depleted suspensions: while useful as a detergent for GNR detoxification, it should be replaced by more robust coatings for long-term stability under physiological conditions. |
8楼2009-09-19 10:16:24
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2楼2009-09-18 17:19:13
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wdwsnnu(金币+1,VIP+0): 9-19 20:20
wdwsnnu(金币+0,VIP+0):注意用词 9-19 20:20
wdwsnnu(金币+1,VIP+0): 9-19 20:20
wdwsnnu(金币+0,VIP+0):注意用词 9-19 20:20
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3楼2009-09-18 19:12:20
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