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各位高手，有没有人可以帮忙下两篇文章啊，谢谢！题目是：Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents。和A single conserved proline residue determines the membrane topology of stomatin. 每篇文章悬赏金币5个！叩谢啦！  |
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nnxqwei
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9楼2009-09-20 10:15:15
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2楼2009-09-16 15:19:19
guotieying
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amisking(金币+3,VIP+0): 9-16 20:23
amisking(金币+3,VIP+0): 9-16 20:23
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Results from tissue microarray in this study and our previous reports revealed that stomatin-like protein 2 (SLP-2) is notably associated with tumorigenesis and metastasis. Many members of stomatin family are involved in tumor as mitochondrial component, and recent study has revealed that SLP-2 may also function in mitochondria. To further investigate the function of SLP-2, we used siRNA target SLP-2. Data showed that knock-down of SLP-2 potently inhibited cell motility, proliferation and slightly altered cell cycle without any significant change of apoptosis. Moreover, by combined application with different chemotherapeutic reagents, we observed the enhancement of cell chemosensitivity by SLP-2 depletion. We also confirmed that, SLP-2 localizes in mitochondria, affects mitochondrial membrane potential (MMP) and ATP production. We conclude that, SLP-2 is a mitochondrial protein and therefore, functions in energy process by MMP maintenance, and subsequently affecting cell motility, proliferation and chemosensitivity. 只找到了摘要，要出19个美元才能下载 |
3楼2009-09-16 15:28:29
hound
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4楼2009-09-16 16:48:32
