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2009年8月Nature biotechnology杂志全文
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如果要下载既往的Nature和Science期刊，请点击 既往期刊下载链接 尊重他人劳动成果，回帖者高尚  http://d.namipan.com/d/Nature%20 ... 2a01c8067a08f119d00 目录：Editorial A blueprint for biotech's blues - p675 doi:10.1038/nbt0809-675 The strategy outlined in the UK's Life Sciences Blueprint is unlikely to address the British biotech sector's woes or help it regain prominence and success. Abstract - | Full Text - A blueprint for biotech's blues | PDF (100 KB) - A blueprint for biotech's blues -------------------------------------------------------------------------------- Top of pageNews Brand biologics grab 12 years' exclusivity, for now - pp677 - 678 Randy Osborne doi:10.1038/nbt0809-677 Full Text - Brand biologics grab 12 years' exclusivity, for now | PDF (1,119 KB) - Brand biologics grab 12 years' exclusivity, for now -------------------------------------------------------------------------------- Awards bridge 'valley of death' - p678 Emma Dorey doi:10.1038/nbt0809-678 Full Text - Awards bridge 'valley of death' | PDF (93 KB) - Awards bridge 'valley of death' -------------------------------------------------------------------------------- J&J's billion dollar punt on anti-amyloid antibody - pp679 - 681 Cormac Sheridan doi:10.1038/nbt0809-679 Full Text - J&J's billion dollar punt on anti-amyloid antibody | PDF (208 KB) - J&J's billion dollar punt on anti-amyloid antibody -------------------------------------------------------------------------------- Virus stalls Genzyme plant - p681 Victor Bethencourt doi:10.1038/nbt0809-681a Full Text - Virus stalls Genzyme plant | PDF (77 KB) - Virus stalls Genzyme plant -------------------------------------------------------------------------------- Stem cell funding widens - p681 James Netterwald doi:10.1038/nbt0809-681b Full Text - Stem cell funding widens | PDF (77 KB) - Stem cell funding widens -------------------------------------------------------------------------------- Bye-bye WilBio - p682 Nazlie Latefi doi:10.1038/nbt0809-682a Full Text - Bye-bye WilBio | PDF (77 KB) - Bye-bye WilBio -------------------------------------------------------------------------------- GM fish ice cream - p682 Anna Meldolesi doi:10.1038/nbt0809-682b Full Text - GM fish ice cream | PDF (77 KB) - GM fish ice cream -------------------------------------------------------------------------------- Novo awaits green light for diabetes drug - pp682 - 685 Mike May doi:10.1038/nbt0809-682c Full Text - Novo awaits green light for diabetes drug | PDF (1,052 KB) - Novo awaits green light for diabetes drug -------------------------------------------------------------------------------- Cellulosic at the pump - p684 Brady Huggett doi:10.1038/nbt0809-684a Full Text - Cellulosic at the pump | PDF (1,017 KB) - Cellulosic at the pump -------------------------------------------------------------------------------- Plasma firms denied merger - p684 Brady Huggett doi:10.1038/nbt0809-684b Full Text - Plasma firms denied merger | PDF (1,017 KB) - Plasma firms denied merger -------------------------------------------------------------------------------- Genzyme's Lumizyme clears bioequivalence hurdles - p685 Mark Ratner doi:10.1038/nbt0809-685a Full Text - Genzyme's Lumizyme clears bioequivalence hurdles | PDF (71 KB) - Genzyme's Lumizyme clears bioequivalence hurdles -------------------------------------------------------------------------------- Peru embraces biotech - p685 Veronica Guerrero doi:10.1038/nbt0809-685b Full Text - Peru embraces biotech | PDF (71 KB) - Peru embraces biotech -------------------------------------------------------------------------------- Illumina's cut-price genome scan - p685 Malorye Allison doi:10.1038/nbt0809-685c Full Text - Illumina's cut-price genome scan | PDF (71 KB) - Illumina's cut-price genome scan -------------------------------------------------------------------------------- Data Page Signs of life in Q2 - p686 Walter Yang doi:10.1038/nbt0809-686 Full Text - Signs of life in Q2 | PDF (247 KB) - Signs of life in Q2 -------------------------------------------------------------------------------- News Features Immunology's quiet upheaval - pp687 - 689 Ken Garber doi:10.1038/nbt0809-687 Several drug programs aim to restore the balance between regulatory T cells and T helper 17 (Th17) cells in autoimmune disease. But as therapies advance in the clinic, new discoveries are challenging the fundamental principle that T-cell lineages, once established, don't change. Ken Garber reports. Abstract - | Full Text - Immunology's quiet upheaval | PDF (182 KB) - Immunology's quiet upheaval -------------------------------------------------------------------------------- The cold rush - pp690 - 692 Hannah Hoag doi:10.1038/nbt0809-690 More than 40 companies are now engaged in bioprospecting in the Arctic. Hannah Hoag gauges the biotech potential buried beneath the ice and snow. Abstract - | Full Text - The cold rush | PDF (174 KB) - The cold rush -------------------------------------------------------------------------------- Top of pageBioentrepreneur Building a business Building today's platform company - pp693 - 695 Guido Lanza doi:10.1038/bioe.2009.6 PDF (203 KB) - Building today's platform company -------------------------------------------------------------------------------- Top of pageOpinion and Comment Correspondence And then there were two: use of hESC lines - pp696 - 697 Christopher Thomas Scott, Jennifer B McCormick & Jason Owen-Smith doi:10.1038/nbt0809-696 Full Text - And then there were two: use of hESC lines | PDF (166 KB) - And then there were two: use of hESC lines -------------------------------------------------------------------------------- BARDA's budget - pp698 - 699 Lynn C Klotz & Alan Pearson doi:10.1038/nbt0809-698 Full Text - BARDA's budget | PDF (157 KB) - BARDA's budget | Supplementary information -------------------------------------------------------------------------------- Reply to BARDA's budget - p699 doi:10.1038/nbt0809-699 Full Text - Reply to BARDA's budget | PDF (89 KB) - Reply to BARDA's budget -------------------------------------------------------------------------------- Detection of genetically modified organisms—closing the gaps - pp700 - 701 Dany Morisset, Tina Demar, Kristina Gruden, Jana Vojvoda, Dejan tebih & Jana el doi:10.1038/nbt0809-700 Full Text - Detection of genetically modified organisms—closing the gaps | PDF (204 KB) - Detection of genetically modified organisms—closing the gaps | Supplementary information -------------------------------------------------------------------------------- The contraction of agbiotech product quality innovation - pp702 - 704 Gregory D Graff, David Zilberman & Alan B Bennett doi:10.1038/nbt0809-702 Full Text - The contraction of agbiotech product quality innovation | PDF (162 KB) - The contraction of agbiotech product quality innovation | Supplementary information -------------------------------------------------------------------------------- Commentary Beyond the biotech IPO: a brave new world - pp705 - 709 Bruce L Booth doi:10.1038/nbt0809-705 After a decade of significant challenges, biotech's long-term sustainability depends on making fundamental changes to its traditional business model. Abstract - | Full Text - Beyond the biotech IPO: a brave new world | PDF (369 KB) - Beyond the biotech IPO: a brave new world -------------------------------------------------------------------------------- |
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Features Public biotech 2008—the numbers - pp710 - 721 Brady Huggett, John Hodgson & Riku Lähteenmäki doi:10.1038/nbt0809-710 The sour global economy has left many small public firms gasping for air. Abstract - | Full Text - Public biotech 2008—the numbers | PDF (428 KB) - Public biotech 2008—the numbers -------------------------------------------------------------------------------- Patents Stem cell patents: a landscape analysis - pp722 - 726 Antoinette F Konski & Doris J F Spielthenner doi:10.1038/nbt0809-722 An evaluation of the development of innovation in stem cell technologies by network analysis of stem cell patent filings. Abstract - | Full Text - Stem cell patents: a landscape analysis | PDF (280 KB) - Stem cell patents: a landscape analysis -------------------------------------------------------------------------------- Recent patent applications in biomarkers - p727 doi:10.1038/nbt0809-727 Full Text - Recent patent applications in biomarkers | PDF (47 KB) - Recent patent applications in biomarkers -------------------------------------------------------------------------------- Top of pageNews and Views Synthetic metabolic pipelines - pp728 - 729 Matthew P DeLisa & Robert J Conrado doi:10.1038/nbt0809-728 Controlling the spatial organization of sequential metabolic enzymes may provide a general strategy for increasing the production of valuable compounds. Abstract - | Full Text - Synthetic metabolic pipelines | PDF (220 KB) - Synthetic metabolic pipelines See also: Research by Dueber et al. -------------------------------------------------------------------------------- Metabolic engineering without plasmids - pp729 - 731 Aashiq H Kachroo, Makkuni Jayaram & Paul A Rowley doi:10.1038/nbt0809-729 Tandem gene duplication is harnessed to genetically engineer Escherichia coli, enabling sustained expression of metabolic products. Abstract - | Full Text - Metabolic engineering without plasmids | PDF (685 KB) - Metabolic engineering without plasmids See also: Research by Tyo et al. -------------------------------------------------------------------------------- Universal cell-free protein synthesis - pp731 - 732 James R Swartz doi:10.1038/nbt0809-731 Unstructured translation-initiation sequences enable protein synthesis in cell extracts from multiple organisms. Abstract - | Full Text - Universal cell-free protein synthesis | PDF (167 KB) - Universal cell-free protein synthesis See also: Research by Mureev et al. -------------------------------------------------------------------------------- Next-generation quantum dots - pp732 - 733 Andrew M Smith & Shuming Nie doi:10.1038/nbt0809-732 Quantum dots that are small and non-blinking offer new opportunities for dynamic single-molecule imaging in live cells. Abstract - | Full Text - Next-generation quantum dots | PDF (570 KB) - Next-generation quantum dots -------------------------------------------------------------------------------- Top of pageResearch Highlights Research highlights - p734 Laura De Francesco, Markus Elsner, Peter Hare & Craig Mak doi:10.1038/nbt0809-734 Full Text - Research highlights | PDF (128 KB) - Research highlights -------------------------------------------------------------------------------- Top of pageComputational Biology Perspective The Systems Biology Graphical Notation - pp735 - 741 Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie, Falk Schreiber, Anatoly Sorokin, Emek Demir, Katja Wegner, Mirit I Aladjem, Sarala M Wimalaratne, Frank T Bergman, Ralph Gauges, Peter Ghazal, Hideya Kawaji, Lu Li, Yukiko Matsuoka, Alice Villéger, Sarah E Boyd, Laurence Calzone, Melanie Courtot, Ugur Dogrusoz, Tom C Freeman, Akira Funahashi, Samik Ghosh, Akiya Jouraku, Sohyoung Kim, Fedor Kolpakov, Augustin Luna, Sven Sahle, Esther Schmidt, Steven Watterson, Guanming Wu, Igor Goryanin, Douglas B Kell, Chris Sander, Herbert Sauro, Jacky L Snoep, Kurt Kohn & Hiroaki Kitano doi:10.1038/nbt.1558 A group of scientists in the systems biology community propose visual conventions for drawing biological diagrams. Abstract - | Full Text - The Systems Biology Graphical Notation | PDF (923 KB) - The Systems Biology Graphical Notation | Supplementary information -------------------------------------------------------------------------------- Top of pageResearch Brief Communications Variation in the safety of induced pluripotent stem cell lines - pp743 - 745 Kyoko Miura, Yohei Okada, Takashi Aoi, Aki Okada, Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Mari Ohnuki, Daisuke Ogawa, Eiji Ikeda, Hideyuki Okano & Shinya Yamanaka doi:10.1038/nbt.1554 The safety of induced pluripotent stem cells seems to depend on how they were generated. Miura et al. examine the effects of the c-myc transgene, tissue of origin and selection method on the tumor-forming propensity of iPS-cell derivatives. First Paragraph - | Full Text - Variation in the safety of induced pluripotent stem cell lines | PDF (468 KB) - Variation in the safety of induced pluripotent stem cell lines | Supplementary information -------------------------------------------------------------------------------- Articles Species-independent translational leaders facilitate cell-free expression - pp747 - 752 Sergei Mureev, Oleksiy Kovtun, Uyen T T Nguyen & Kirill Alexandrov doi:10.1038/nbt.1556 Initiation of translation is an obstacle in the development of eukaryotic systems for cell-free protein synthesis. Mureev et al. describe a translational leader sequence that efficiently drives protein production in cell lysates from several eukaryotes and prokaryotes and use this sequence to develop a cell-free system based on Leishmania tarentolae. Abstract - | Full Text - Species-independent translational leaders facilitate cell-free expression | PDF (701 KB) - Species-independent translational leaders facilitate cell-free expression | Supplementary information See also: News and Views by Swartz -------------------------------------------------------------------------------- Synthetic protein scaffolds provide modular control over metabolic flux - pp753 - 759 John E Dueber, Gabriel C Wu, G Reza Malmirchegini, Tae Seok Moon, Christopher J Petzold, Adeeti V Ullal, Kristala L J Prather & Jay D Keasling doi:10.1038/nbt.1557 Engineered metabolic pathways are usually devoid of the regulatory mechanisms characteristic of natural metabolism. Using pathways not normally found in E. coli, Dueber et al. show that synthetic scaffolds built using protein-protein interaction domains can boost yields of mevalonate and glucaric acid. Abstract - | Full Text - Synthetic protein scaffolds provide modular control over metabolic flux | PDF (638 KB) - Synthetic protein scaffolds provide modular control over metabolic flux | Supplementary information See also: News and Views by DeLisa & Conrado -------------------------------------------------------------------------------- Stabilized gene duplication enables long-term selection-free heterologous pathway expression - pp760 - 765 Keith E J Tyo, Parayil Kumaran Ajikumar & Gregory Stephanopoulos doi:10.1038/nbt.1555 Although new metabolic pathways are generally introduced into bacteria on plasmids, this approach is limited by declining productivity after several generations. Tyo et al. describe a method for chromosome engineering that enables sustained production of a biopolymer or a nutraceutical. Abstract - | Full Text - Stabilized gene duplication enables long-term selection-free heterologous pathway expression | PDF (473 KB) - Stabilized gene duplication enables long-term selection-free heterologous pathway expression | Supplementary information See also: News and Views by Kachroo et al. -------------------------------------------------------------------------------- Letter Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo - pp767 - 771 Aran F Labrijn, Antonio Ortiz Buijsse, Ewald T J van den Bremer, Annemiek Y W Verwilligen, Wim K Bleeker, Susan J Thorpe, Joep Killestein, Chris H Polman, Rob C Aalberse, Janine Schuurman, Jan G J van de Winkel & Paul W H I Parren doi:10.1038/nbt.1553 Although never demonstrated in humans, exchange of the antigen-binding regions of IgG4 antibodies with different specificities could complicate certain antibody therapies. Labrijn et al. show that Fab-arm exchange occurs in patients and propose that a single mutation can inhibit the process. First Paragraph - | Full Text - Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo | PDF (503 KB) - Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo | Supplementary information -------------------------------------------------------------------------------- Top of pageCareers and Recruitment Seeding a skilled workforce - pp773 - 775 Gayatri Saberwal doi:10.1038/nbt0809-773 How might the Indian government spur the development of a biotech workforce with a broader set of skills? Abstract - | Full Text - Seeding a skilled workforce | PDF (98 KB) - Seeding a skilled workforce -------------------------------------------------------------------------------- People People - p776 doi:10.1038/nbt0809-776 Full Text - People | PDF (80 KB) - People -------------------------------------------------------------------------------- |
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