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2009年9月Nature biotechnology杂志全文
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如果要下载既往的Nature和Science期刊，请点击 既往期刊下载链接 尊重他人劳动成果，回帖者高尚  http://www.namipan.com/d/Nature% ... 55532dc1298b20bcf00 目录：Editorial DNA confidential - p777 doi:10.1038/nbt0909-777 As the cost of human genome sequencing plunges and large-scale genome-phenotype studies become possible, society should do more to reward those individuals who choose to disclose their data, despite the risks. Abstract - | Full Text - DNA confidential | PDF (104 KB) - DNA confidential -------------------------------------------------------------------------------- Top of pageNews Human Genome Sciences trial data wow lupus community - pp779 - 780 Mark Ratner doi:10.1038/nbt0909-779 Full Text - Human Genome Sciences trial data wow lupus community | PDF (450 KB) - Human Genome Sciences trial data wow lupus community -------------------------------------------------------------------------------- Bristol-Myers Squibb swallows last of antibody pioneers - pp781 - 783 Malorye Allison doi:10.1038/nbt0909-781 Full Text - Bristol-Myers Squibb swallows last of antibody pioneers | PDF (297 KB) - Bristol-Myers Squibb swallows last of antibody pioneers -------------------------------------------------------------------------------- Big oil bucks for algae - p783 Cormac Sheridan doi:10.1038/nbt0909-783 Full Text - Big oil bucks for algae | PDF (100 KB) - Big oil bucks for algae -------------------------------------------------------------------------------- PARP inhibitors blaze a trail in difficult-to-treat cancers - pp784 - 786 Jim Kling doi:10.1038/nbt0909-784 Full Text - PARP inhibitors blaze a trail in difficult-to-treat cancers | PDF (316 KB) - PARP inhibitors blaze a trail in difficult-to-treat cancers -------------------------------------------------------------------------------- VC firms push for REMS - p785 Nazlie Latefi doi:10.1038/nbt0909-785a Full Text - VC firms push for REMS | PDF (82 KB) - VC firms push for REMS -------------------------------------------------------------------------------- Alnylam casts IP into pool - p785 Catherine Shaffer doi:10.1038/nbt0909-785b Full Text - Alnylam casts IP into pool | PDF (82 KB) - Alnylam casts IP into pool -------------------------------------------------------------------------------- Consumer genomics battle lines drawn - p786 Laura DeFrancesco doi:10.1038/nbt0909-786a Full Text - Consumer genomics battle lines drawn | PDF (101 KB) - Consumer genomics battle lines drawn -------------------------------------------------------------------------------- Biocon, Mylan in pan-biogenerics deal - p786 Killugudi Jayaraman doi:10.1038/nbt0909-786b Full Text - Biocon, Mylan in pan-biogenerics deal | PDF (101 KB) - Biocon, Mylan in pan-biogenerics deal -------------------------------------------------------------------------------- China tightens IP protection, but concerns linger - pp787 - 788 Hepeng Jia doi:10.1038/nbt0909-787 Full Text - China tightens IP protection, but concerns linger | PDF (245 KB) - China tightens IP protection, but concerns linger -------------------------------------------------------------------------------- Canada ends EU row over GM products - p788 Emma Dorey doi:10.1038/nbt0909-788a Full Text - Canada ends EU row over GM products | PDF (82 KB) - Canada ends EU row over GM products -------------------------------------------------------------------------------- Pakistan's first biotech plant - p788 Susan Aldridge doi:10.1038/nbt0909-788b Full Text - Pakistan's first biotech plant | PDF (82 KB) - Pakistan's first biotech plant -------------------------------------------------------------------------------- Data Page Trends in biotech literature 2008 - p789 Andrew Marshall doi:10.1038/nbt0909-789 Full Text - Trends in biotech literature 2008 | PDF (213 KB) - Trends in biotech literature 2008 -------------------------------------------------------------------------------- News Feature Trading on hope - pp790 - 792 Jane Qiu doi:10.1038/nbt0909-790 Jane Qiu investigates the thriving business of selling stem cell transplants as cure-alls for debilitating diseases. Abstract - | Full Text - Trading on hope | PDF (228 KB) - Trading on hope | Supplementary information -------------------------------------------------------------------------------- Top of pageBioentrepreneur Building a business Playing to win - pp793 - 796 Raymond Sekula, Sasha Bakhru & Stefan Zappe doi:10.1038/bioe.2009.7 |
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Opinion and Comment Correspondence Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray - pp797 - 799 Robert A Childs, Angelina S Palma, Steve Wharton, Tatyana Matrosovich, Yan Liu, Wengang Chai, Maria A Campanero-Rhodes, Yibing Zhang, Markus Eickmann, Makoto Kiso, Alan Hay, Mikhail Matrosovich & Ten Feizi doi:10.1038/nbt0909-797 Full Text - Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray | PDF (311 KB) - Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray | Supplementary information -------------------------------------------------------------------------------- Preventing the misuse of gene synthesis - pp800 - 801 Jeremy Minshull & Ralf Wagner doi:10.1038/nbt0909-800 Full Text - Preventing the misuse of gene synthesis | PDF (205 KB) - Preventing the misuse of gene synthesis -------------------------------------------------------------------------------- Reply to Preventing the misuse of gene synthesis - p801 doi:10.1038/nbt0909-801a Full Text - Reply to Preventing the misuse of gene synthesis | PDF (159 KB) - Reply to Preventing the misuse of gene synthesis -------------------------------------------------------------------------------- Commercialized GM crops and yield - pp801 - 802 Doug Gurian-Sherman doi:10.1038/nbt0909-801b Full Text - Commercialized GM crops and yield | PDF (170 KB) - Commercialized GM crops and yield -------------------------------------------------------------------------------- Commercialized GM crops and yield - pp802 - 803 David Schubert doi:10.1038/nbt0909-802 Full Text - Commercialized GM crops and yield | PDF (168 KB) - Commercialized GM crops and yield -------------------------------------------------------------------------------- Reply to Commercialized GM crops and yield - p803 doi:10.1038/nbt0909-803a Full Text - Reply to Commercialized GM crops and yield | PDF (157 KB) - Reply to Commercialized GM crops and yield -------------------------------------------------------------------------------- Commercialized GM crops and yield - pp803 - 804 Matin Qaim, Arjunan Subramanian & Prakash Sadashivappa doi:10.1038/nbt0909-803b Full Text - Commercialized GM crops and yield | PDF (209 KB) - Commercialized GM crops and yield -------------------------------------------------------------------------------- The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 - pp804 - 805 Norman R Saunders, C Joakim Ek & Katarzyna M Dziegielewska doi:10.1038/nbt0909-804 Full Text - The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 | PDF (147 KB) - The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 -------------------------------------------------------------------------------- Reply to The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 - p805 doi:10.1038/nbt0909-805 Full Text - Reply to The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 | PDF (290 KB) - Reply to The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9 -------------------------------------------------------------------------------- Top of pageFeatures Globetrotting firms: Canada's health biotechnology collaborations with developing countries - pp806 - 814 Monali Ray, Abdallah S Daar, Peter A Singer & Halla Thorsteinsdóttir doi:10.1038/nbt0909-806 A survey of Canadian biotech firms reveals that their biotech collaborations with developing countries are not only significant but also increasingly reciprocal in terms of the exchange of financial resources and technological know-how. Abstract - | Full Text - Globetrotting firms: Canada's health biotechnology collaborations with developing countries | PDF (554 KB) - Globetrotting firms: Canada's health biotechnology collaborations with developing countries | Supplementary information -------------------------------------------------------------------------------- Patents Accelerated patent examination procedures spur Japanese university innovation - pp815 - 818 John A Tessensohn & Shusaku Yamamoto doi:10.1038/nbt0909-815 Two recent events—the issuance of the world's first patent for induced pluripotent stem cells and, under a pilot system, the issuance of the fastest patent ever granted—signal a watershed in Japanese academia's transition from gown to town. Abstract - | Full Text - Accelerated patent examination procedures spur Japanese university innovation | PDF (337 KB) - Accelerated patent examination procedures spur Japanese university innovation |
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-------------------------------------------------------------------------------- Recent patent applications in drug screening - p819 doi:10.1038/nbt0909-819 Full Text - Recent patent applications in drug screening | PDF (49 KB) - Recent patent applications in drug screening -------------------------------------------------------------------------------- Top of pageNews and Views Faster human genome sequencing - pp820 - 821 Yingrui Li & Jun Wang doi:10.1038/nbt0909-820 Advances in parallelization allow a human genome to be sequenced using single-molecule technology. Abstract - | Full Text - Faster human genome sequencing | PDF (172 KB) - Faster human genome sequencing -------------------------------------------------------------------------------- Silencing prostate cancer - pp821 - 823 Ivanka Toudjarska & Antonin de Fougerolles doi:10.1038/nbt0909-821 Systemic delivery of an siRNA–aptamer chimera leads to prostate cancer regression in mice. Abstract - | Full Text - Silencing prostate cancer | PDF (307 KB) - Silencing prostate cancer See also: Research by Dassie et al. -------------------------------------------------------------------------------- Reshaping pluripotent stem cells - pp823 - 824 Andrew G Elefanty & Edouard G Stanley doi:10.1038/nbt0909-823 Engineered zinc-finger nucleases are used to generate several genetically modified pluripotent stem cell lines. Abstract - | Full Text - Reshaping pluripotent stem cells | PDF (590 KB) - Reshaping pluripotent stem cells See also: Research by Hockemeyer et al. -------------------------------------------------------------------------------- Absolute abundance for the masses - pp825 - 826 Christine Vogel & Edward M Marcotte doi:10.1038/nbt0909-825 Mass spectrometry can now measure the absolute concentrations of the majority of cellular proteins without labeling. Abstract - | Full Text - Absolute abundance for the masses | PDF (240 KB) - Absolute abundance for the masses -------------------------------------------------------------------------------- Combinatorics and next-generation sequencing - pp826 - 827 Nick Patterson & Stacey Gabriel doi:10.1038/nbt0909-826 The massive capacity of today's sequencing machines can be harnessed efficiently by sequencing pooled samples and decoding the results. Abstract - | Full Text - Combinatorics and next-generation sequencing | PDF (2,138 KB) - Combinatorics and next-generation sequencing -------------------------------------------------------------------------------- Top of pageResearch Highlights Research highlights - p828 Kathy Aschheim, Laura De Francesco, Markus Elsner, Peter Hare & Craig Mak doi:10.1038/nbt0909-828 Full Text - Research highlights | PDF (134 KB) - Research highlights -------------------------------------------------------------------------------- Top of pageComputational Biology Analysis Genome-wide identification of post-translational modulators of transcription factor activity in human B cells - pp829 - 837 Kai Wang, Masumichi Saito, Brygida C Bisikirska, Mariano J Alvarez, Wei Keat Lim, Presha Rajbhandari, Qiong Shen, Ilya Nemenman, Katia Basso, Adam A Margolin, Ulf Klein, Riccardo Dalla-Favera & Andrea Califano doi:10.1038/nbt.1563 Modulatory proteins ensure that transcription factors are active when and where they should be. Wang et al. describe an algorithm for identifying modulators from a compendium of gene expression profiles and experimentally validate four diverse modulators of the MYC oncogene in human B cells. Abstract - | Full Text - Genome-wide identification of post-translational modulators of transcription factor activity in human B cells | PDF (2,400 KB) - Genome-wide identification of post-translational modulators of transcription factor activity in human B cells | Supplementary information -------------------------------------------------------------------------------- Top of pageResearch Article Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors - pp839 - 846 Justin P Dassie, Xiu-ying Liu, Gregory S Thomas, Ryan M Whitaker, Kristina W Thiel, Katie R Stockdale, David K Meyerholz, Anton P McCaffrey, James O McNamara II & Paloma H Giangrande doi:10.1038/nbt.1560 Systemic delivery remains a major obstacle in therapeutic applications of siRNAs. Using RNA aptamer–siRNA chimeras with enhanced silencing activity and specificity, Dassie et al. achieve regression of xenograft prostate tumors by intraperitoneal injection. Abstract - | Full Text - Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors | PDF (1,071 KB) - Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors | Supplementary information See also: News and Views by Toudjarska & de Fougerolles -------------------------------------------------------------------------------- Letters Single-molecule sequencing of an individual human genome - pp847 - 850 Dmitry Pushkarev, Norma F Neff & Stephen R Quake doi:10.1038/nbt.1561 Pushkarev et al. present the first human genome sequence obtained using single-molecule sequencing technology. These results demonstrate that human genome sequencing—previously the turf of large sequencing centers—is now within reach of an individual lab in a matter of weeks. First Paragraph - | Full Text - Single-molecule sequencing of an individual human genome | PDF (804 KB) - Single-molecule sequencing of an individual human genome | Supplementary information -------------------------------------------------------------------------------- Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases - pp851 - 857 Dirk Hockemeyer, Frank Soldner, Caroline Beard, Qing Gao, Maisam Mitalipova, Russell C DeKelver, George E Katibah, Ranier Amora, Elizabeth A Boydston, Bryan Zeitler, Xiangdong Meng, Jeffrey C Miller, Lei Zhang, Edward J Rebar, Philip D Gregory, Fyodor D Urnov & Rudolf Jaenisch doi:10.1038/nbt.1562 Hockemeyer et al. demonstrate targeted genetic modification of three genes in human embryonic stem cells and induced pluripotent stem cells using zinc-finger nucleases delivered on plasmids. They use the approach to generate a reporter cell line that monitors the pluripotent state, a drug-inducible overexpression system, and a reporter cell line for a gene that is not expressed in pluripotent stem cells. Abstract - | Full Text - Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases | PDF (1,189 KB) - Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases | Supplementary information See also: News and Views by Elefanty & Stanley -------------------------------------------------------------------------------- Sensitive digital quantification of DNA methylation in clinical samples - pp858 - 863 Meng Li, Wei-dong Chen, Nickolas Papadopoulos, Steven N Goodman, Niels Christian Bjerregaard, Søren Laurberg, Bernard Levin, Hartmut Juhl, Nadir Arber, Helen Moinova, Kris Durkee, Kerstin Schmidt, Yiping He, Frank Diehl, Victor E Velculescu, Shibin Zhou, Luis A Diaz Jr, Kenneth W Kinzler, Sanford D Markowitz & Bert Vogelstein doi:10.1038/nbt.1559 Gene-specific changes in DNA methylation are promising biomarkers, but sensitive quantitative detection of these epigenetic marks remains challenging. Li et al. adapt the so-called BEAMing technology to enable high-throughput digital quantification of gene methylation in clinical samples. First Paragraph - | Full Text - Sensitive digital quantification of DNA methylation in clinical samples | PDF (596 KB) - Sensitive digital quantification of DNA methylation in clinical samples | Supplementary information -------------------------------------------------------------------------------- Corrigenda Corrigendum: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins - p864 Bernd Wollscheid, Damaris Bausch-Fluck, Christine Henderson, Robert O'Brien, Miriam Bibel, Ralph Schiess, Ruedi Aebersold & Julian D Watts doi:10.1038/nbt0909-864a Full Text - Corrigendum: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins | PDF (64 KB) - Corrigendum: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins -------------------------------------------------------------------------------- Corrigendum: Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma - p864 Terri A Addona, Susan E Abbatiello, Birgit Schilling, Steven J Skates, D R Mani, David M Bunk, Clifford H Spiegelman, Lisa J Zimmerman, Amy-Joan L Ham, Hasmik Keshishian, Steven C Hall, Simon Allen, Ronald K Blackman, Christoph H Borchers, Charles Buck, Helene L Cardasis, Michael P Cusack, Nathan G Dodder, Bradford W Gibson, Jason M Held, Tara Hiltke, Angela Jackson, Eric B Johansen, Christopher R Kinsinger, Jing Li, Mehdi Mesri, Thomas A Neubert, Richard K Niles, Trenton C Pulsipher, David Ransohoff, Henry Rodriguez, Paul A Rudnick, Derek Smith, David L Tabb, Tony J Tegeler, Asokan M Variyath, Lorenzo J Vega-Montoto, Åsa Wahlander, Sofia Waldemarson, Mu Wang, Jeffrey R Whiteaker, Lei Zhao, N Leigh Anderson, Susan J Fisher, Daniel C Liebler, Amanda G Paulovich, Fred E Regnier, Paul Tempst & Steven A Carr doi:10.1038/nbt0909-864b Full Text - Corrigendum: Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma | PDF (66 KB) - Corrigendum: Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma -------------------------------------------------------------------------------- Errata Erratum: Synergistic drug combinations tend to improve therapeutically relevant selectivity - p864 Joseph Lehár, Andrew S Krueger, William Avery, Adrian M Heilbut, Lisa M Johansen, E Roydon Price, Richard J Rickles, Glenn F Short III, Jane E Staunton, Xiaowei Jin, Margaret S Lee, Grant R Zimmermann & Alexis A Borisy doi:10.1038/nbt0909-864c Full Text - Erratum: Synergistic drug combinations tend to improve therapeutically relevant selectivity | PDF (64 KB) - Erratum: Synergistic drug combinations tend to improve therapeutically relevant selectivity -------------------------------------------------------------------------------- Erratum: The Systems Biology Graphical Notation - p864 Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie, Falk Schreiber, Anatoly Sorokin, Emek Demir, Katja Wegner, Mirit I Aladjem, Sarala M Wimalaratne, Frank T Bergman, Ralph Gauges, Peter Ghazal, Hideya Kawaji, Lu Li, Yukiko Matsuoka, Alice Villéger, Sarah E Boyd, Laurence Calzone, Melanie Courtot, Ugur Dogrusoz, Tom C Freeman, Akira Funahashi, Samik Ghosh, Akiya Jouraku, Sohyoung Kim, Fedor Kolpakov, Augustin Luna, Sven Sahle, Esther Schmidt, Steven Watterson, Guanming Wu, Igor Goryanin, Douglas B Kell, Chris Sander, Herbert Sauro, Jacky L Snoep, Kurt Kohn & Hiroaki Kitano doi:10.1038/nbt0909-864d Full Text - Erratum: The Systems Biology Graphical Notation | PDF (65 KB) - Erratum: The Systems Biology Graphical Notation -------------------------------------------------------------------------------- Erratum: Table of Contents - p864 doi:10.1038/nbt0909-864e Full Text - Erratum: Table of Contents | PDF (63 KB) - Erratum: Table of Contents -------------------------------------------------------------------------------- Top of pageCareers and Recruitment Interview essentials for executives: beyond the basics - pp865 - 866 Mary Ann Rafferty doi:10.1038/nbt0909-865 Tips for competing successfully for a senior position in a biotech company. Abstract - | Full Text - Interview essentials for executives: beyond the basics | PDF (110 KB) - Interview essentials for executives: beyond the basics -------------------------------------------------------------------------------- People People - p868 doi:10.1038/nbt0909-868 Full Text - People | PDF (88 KB) - People -------------------------------------------------------------------------------- |
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