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药知海洋

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虫号: 32060205
注册: 2022-11-01
专业: 药物分析

[求助] 溶出度自动分析仪器问题

各位大神，
如下描述的的自动分析仪器检检溶出的设备，有了解的嘛？是溶出紫外一体机嘛？
求指教！
Apparatus: Automatic analyzer consisting of (1) a liquid
sampler, (2) a proportioning pump, (3) suitable
spectrophotometers equipped with matched flow cells and
analysis capability at 480 nm, (4) a means of recording
spectrophotometric readings, and/or computer for data
retrieval and calculation, and (5) a manifold consisting of
the components illustrated in Figure 1.
Analysis: With the sample line pumping water, the other
lines pumping their respective reagents, and the
spectrophotometer set at 480 nm, standardize the system
until a steady absorbance baseline has been established.
Transfer portions of the Standard solution and the Sample
solution to sampler cups, and place in the sampler. Start the
sampler, and conduct determinations of the Standard
solution and the Sample solution typically at the rate of 40/
h using a ratio of about 2:1 for sample and wash time.
Calculate the percentage of the labeled amount of
ampicillin (C16H19N3O4S) dissolved:
Result = (AU/AS) × CS × V × P × F × (1/L) × 100
AU = absorbance of the Sample solution
AS = absorbance of the Standard solution
CS = concentration of USP Ampicillin RS in the
Standard solution (mg/mL)
V = volume of Medium, 900 mL
P = potency of ampicillin in USP Ampicillin RS
(μg/mg)
F = conversion factor, 0.001 mg/μg
L = label claim (mg/Capsule)

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