| 查看: 547 | 回复: 10 | |||
[交流]
系统生物学读博全奖，CSC-University Maastricht 项目 3
|
|||
|
Project title: Mechanisms and role of axon-myelin structural plasticity in learning and information processing Project leader: Prof. Dr. Renaud Jolivet and Dr. Michelle Moerel Function: Professor of Neural Engineering and Computation Collaborators: Prof. Kaylene Young, University of Tasmania Dr. Helmut Schmidt, Institute of Computer Science, Czech Academy of Sciences Proposal (250 words): Introduction: Our group and collaborators have recently discovered a new type of structural plasticity in the brain between axons – the structure through which neurons propagate electrical signals – and the myelin coverage of axons – the structure that ensures the speedy, reliable, and energetically efficient propagation of those signals. Experimental evidence suggests that this newly identified form of plasticity is important in learning, for instance for the coordination of fine motor tasks, and can be induced or modulated by external interventions such as transcranial magnetic stimulation. Hypothesis and Objectives: This project will investigate in computational biology simulations, the biophysics underlying this new form of plasticity. Setting and Methods: We will investigate the role of potassium channels located underneath the myelin coverage at juxtaparanodes. We will test the hypothesis that changes in the volume of the periaxonal space affect the degree of coupling between parallel myelinated axons. We will also ask how this structural plasticity can shape information flow in neural networks by simulating its effects on the propagation failure of neurons’ electrical signals, and on the time course of these signals. Finally, we will investigate a possible link between this new form of structural plasticity and the metabolic coupling of axons and myelin sheaths. The project will make extensive use of MATLAB, COMSOL and NEURON packages, and will involve collaborators in Hobart, Tasmania, and Prague, Czech Republic. Impact: The project addresses a new form of neural plasticity, and will have a profound impact on our understanding of learning in the brain, but also potentially on the design of new types of machine learning algorithms in spiking neural networks. Requirements candidate: Highly motivated student with good English communication skills, and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in computational neuroscience, and some computational skills, preferably in MATLAB or COMSOL. Applicants with other profiles are still welcome if the applicant can make a case for being able to catch up in programming and computational aspects. Prior participation to the Neuromatch Academy would be highly appreciated. Keywords: Basic Research, Biological Foundations of Human Health and Diseases, Computational Biology, Neuroscience, Scientific Basis for Development of Information Technology Top 5 selected publications: 1. Myelin and nodal plasticity modulate action potential conduction in the adult mouse brain Cullen CL, Pepper RE, Clutterbuck MT, Pitman KA, Oorschot V, Auderset L, Tang AD, Ramm G, Emery B, Rodger J, Jolivet RB & Young KM Cell Reports 34:108641, 2021 [JIF 9.4; quartile Q1; 15 citations Web of Science] 2. Magnetic moments of short-lived nuclei with part-per-million accuracy: Towards novel applications of ß-detected NMR in physics, chemistry and biology Harding RD, Pallada S, Croese J, Antušek A, Baranowski M, Bissell ML, Cerato L, Dziubinska-Kühn KM, Gins W, Gustafsson FP, Javaji A, Jolivet RB, Kanellakopoulos A, Karg B, Kempka M, Kocman V, Kozak M, Kulesz K, Madurga Flores M, Neyens G, Pietrzyk R, Plavec J, Pomorski M, Skrzypczak A, Wagenknecht P, Wienholtz F, Wolak J, Xu Z, Zakoucky D & Kowalska M Physical Review X 10:041061, 2020 [JIF 15.8; quartile Q1; 5 citations Web of Science] 3. Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders Caruso G, Caraci F & Jolivet RB Progress in Neurobiology 175:35–53, 2019 [JIF 11.7; quartile Q1; 42 citations Web of Science] 4. Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1 Madry C*, Kyrargyri V*, Arancibia-Cárcamo IL*, Jolivet RB*, Kohsaka S, Bryan RM & Attwell D Neuron 97:299–312, 2018 [JIF 17.2; quartile Q1; top 1% cited in Neuroscience & Behavior; 182 citations Web of Science] 5. A Process for Digitizing and Simulating Biologically Realistic Oligocellular Mesoscale Networks Demonstrated for the Neuron-Glia-Vasculature Ensemble Coggan JS, Calì C, Keller D, Lehväslaiho H, Agus M, Boges D, Kare K, Abdellah M, Eilemann S, Holst G, Favreau C, Hadwiger M, Jolivet RB, Markram H, Schürmann F & Magistretti PJ Frontiers in Neuroscience 12:664, 2018 [JIF 4.7; quartile Q2; 18 citations Web of Science] Additional details - Duration: Four years - No mandatory course work - English: Good score on TOEFL, IELTS or other test beneficial, but English language skills will be gauged primarily during personal interview - Cooperative program - Maastricht University has limited number of reserved spots; beyond these, application through general program possible - Further information: - www.maastrichtuniversity.nl/um-china-team#um-csc - www.maastrichtuniversity.nl/phd-project-outlines - Contact details: - Prof. Dr. Renaud Jolivet: r.jolivet@maastrichtuniversity.nl |
回复此楼» 猜你喜欢
售渎SCI文章，我:8⊙ 55 1⊙ 54。备注【⊙=0】
已经有5人回复
-
售渎SCI文章，我:8⊙ 55 1⊙ 54。备注【⊙=0】
已经有3人回复
-
接受26届调剂生
已经有10人回复
-
售渎SCI文章，我:8⊙ 55 1⊙ 54。备注【⊙=0】
已经有8人回复
-
A区一本交叉课题组，低分调剂，招收机械电子信息通信等交叉方向
已经有46人回复
-
化学工程与技术316求调剂
已经有4人回复
-
材料调剂
已经有13人回复
-
085600材料与化工 292分 求调剂
已经有3人回复
-
273求调剂
已经有7人回复
-
334求调剂
已经有3人回复
» 抢金币啦！回帖就可以得到:
-
[求助]日本动漫里用手表和三角板测经纬度是怎么回事？
+1/188
-
青岛科技大学JIEQING团队招收材料科学、化学化工相关领域的硕/博研究生数名
+1/83
-
招聘换能器工程师/声学工程师！！！
+1/81
-
绿色催化氧化团队接收调剂研究生
+1/16
-
【2026考研学子们可以关注一下南昌的一所一本高校】门口有地铁 15min车程有高铁。
+1/15
-
26届计算机、电子信息类、电科、控制、通信考研T j信息pp骏：74+08+76+6+20/
+1/14
-
华中科技大学牛广达教授招聘博士后
+1/13
-
中国科学院国家级人才团队博士后招聘启示
+1/10
-
【博士招生】北方工业大学招收 机械工程方向 申请考核制博士
+1/9
-
齐鲁工业大学轻工学部、绿色造纸与资源循环全国重点实验室招收一志愿或调剂研究生
+1/6
-
计算三阶力常数用thirdorder扩胞时参数如何选择？临近原子数怎么取值
+1/6
-
浙江大学基础医学院杨林课题组诚聘合成药物化学方向科研助理
+1/5
-
LiOH高温烧结
+1/4
-
中南林业科技大学生物质绿色转化与功能材料课题组现招收2026年秋季入学博士研究生
+1/3
-
清华大学环境学院李淼教授课题组(长江学者团队)招聘博士后
+1/3
-
澳洲皇家墨尔本理工RMIT招收【AI隐私安全， 隐私计算方向】 CSC访问学者 联合培养
+1/2
-
深圳大学何传新课题组诚聘博士后、（副）研究员
+1/1
-
中国科学院大学杭州高等研究院 胶体量子点材料与器件方向 博士后招聘
+1/1
-
山东大学高性能传感器与大数据分析团队诚聘博士后
+1/1
-
青岛科技大学高分子学院老师招收硕士生2名
+1/1
7楼2022-10-16 22:10:32
9楼2022-11-15 11:07:47
10楼2022-11-17 13:16:44
简单回复
bjdxyxy2楼
2022-09-19 19:19
回复
Strawberrix(金币+1): 谢谢参与
。 发自小木虫Android客户端
tzynew3楼
2022-09-19 19:41
回复
Strawberrix(金币+1): 谢谢参与
o 发自小木虫Android客户端
XG-WUST4楼
2022-09-19 22:00
回复
Strawberrix(金币+1): 谢谢参与
up 发自小木虫IOS客户端
2022-09-19 22:02
回复
Strawberrix(金币+1): 谢谢参与
kingluck6楼
2022-09-19 23:17
回复
Strawberrix(金币+1): 谢谢参与
2022-11-03 12:11
回复
顶一下
Strawberrix11楼
2022-11-21 21:15
回复
Up
