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Examples of mechanisms of genotoxicity that may be demonstrated to lead to non-linear or thresholded dose-response relationships include interaction with the spindle apparatus of cell division leading to aneuploidy, topoisomerase inhibition, inhibition of DNA synthesis, overloading of defence mechanisms, metabolic overload and physiological perturbations (e.g. induction of erythropoeisis, hyper- or hypothermia). [ Last edited by chzhbin on 2009-9-13 at 14:04 ] |
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chzhbin(½ð±Ò+8,VIP+0): 9-13 16:00
chzhbin(½ð±Ò+8,VIP+0): 9-13 16:00
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