| ²é¿´: 512 | »Ø¸´: 0 | |||
guying03Ìú¸Ëľ³æ (СÓÐÃûÆø)
|
[½»Á÷]
µÂ¹úСó¹µÄBr¨CC¸´ºÏÌåºÍ³á°ò·¢ÓýÑо¿
|
|
µÂ¹úСó¹µÄBr¨CC¸´ºÏÌåºÍ³á°ò·¢ÓýÑо¿ ÔÚ°ë±ä̬À¥³æÖУ¬×ªÂ¼Òò×ӹ㷺¸´ºÏÎBr¨CC£©´Ù½øÈô³æÆÚµÄ³á°òÉú³¤ºÍ·¢Óý¡£¸ÃÑо¿ÒԵ¹úСó¹ÎªÄ£ÐÍ£¬Ì½ÌÖBr¨CCÊÇ·ñÄÜÆô¶¯³á°òµÄ·¢Óý¡£ ½á¹û±íÃ÷£¬Ò»ÁäÈô³æÔÚÕâÈý¸öÐØ¶ÎÖÐÓÐÆä¶ÀÌØµÄÉí·Ý¡£ÔÚÅßÌ¥·¢Éú¹ý³ÌÖУ¬Br¨CCºÍһЩ³á°òÏà¹Ø»ùÒòµÄ±í´ï³ÊÏÖÁ½¸öÆ¥Å䲨¡£µÚÒ»´Î·¢ÉúÔÚÅßÑ¿´øÐγÉ֮ǰ£¬Õâ¿ÉÄÜÉæ¼°½¨Á¢¸÷ÖÖ·¢ÓýÁìÓò£¬°üÀ¨Ç±Ôڵġ°³á°òÁìÓò¡±£¬µÚ¶þ´Î·¢ÉúÔÚÆ÷¹Ù·¢ÉúÖÜΧ£¬¿ÉÄÜÉæ¼°³á°ò·¢ÓýµÄÆô¶¯¡£ ͼƬ ͼ 1. Broad¸´ºÏÎBr¨CC£©ºÍ³á°òÏà¹Ø»ùÒòµÄ±í´ï È»¶ø£¬Br¨CCÔÚÔçÆÚÅßÌ¥·¢ÓýÖеıí´ï¼¯ÖÐÔÚ·¢ÓýÖеÄÖÐÊàÉñ¾ÏµÍ³£¬Òò´ËÓëµäÐ͵ijá°òÏà¹Ø»ùÒò²ÐÓà»ùÒòµÄ±í´ï²»¹²¶¨Î»£¬¸Ã»ùÒò±í´ïÔÚÐØ¶ÎºÍ¸¹¶ÎµÄ±ßÔµ¡£Õâ±íÃ÷Br¨CCÔÚÔçÆÚÅßÌ¥·¢ÉúÖв¢²»Ìرð²ÎÓëDZÔÚ¡°Òí³¡¡±µÄ½¨Á¢¡£ ͼƬ ͼ 2. ÔλÔÓ½»£¨ISH£©Ôڵ¹úСó¹ÅßÌ¥Öж¨Î»Ëùѡת¼±¾ ´ËÍ⣬Br¨CCµÄĸÌåRNAiºÄ¾¡ÁËBr¨CC±í´ïµÄµÚÒ»²¨£¬µ«²»Ó°Ïì³á°òÏà¹Ø»ùÒòµÄÔçÆÚ±í´ï¡£ÓÉÓÚĸÌåBr¨CC RNAiûÓкľ¡Br¨CCµÄµÚ¶þ¸ö±í´ï²¨£¬ÎÒÃÇÎÞ·¨ÆÀ¹ÀBr¨CCÊÇ·ñ²ÎÓë³á°ò·¢ÓýµÄÆô¶¯¡£ ͼƬ ͼ 3. ĸÌåRNAi¶ÔµÂ¹úСó¹Br¨CC¸´ºÏÎïºÍ³á°ò·¢ÓýÏà¹Ø»ùÒò±í´ïµÄÓ°Ïì ÀûÓÃRNAiÒÖÖÆÈô³æBr¨CCºÍScrµÄ±í´ï£¬±íÃ÷Br¨CCÓÐÖúÓÚÐγÉÒìλ³á°ò½á¹¹£¬µ±Scr¼õÉÙʱ£¬ÕâЩ½á¹¹ÔÚÇ°ÐØ·¢Óý¡£ ͼƬ ͼ 4. RNAiÒÖÖÆBr¨CCºÍScr¶ÔµÂ¹úСó¹³á°òÏà¹Ø»ùÒò±í´ïºÍÇ°ÐØ±íÐ͵ÄÓ°Ïì ÊÜBr¨CC RNAiÓ°Ïì×îÃ÷ÏԵĻùÒòÊÇnubbin£¨nub£©£¬ËüÔÚÈô³æÖжԳá°òÉú³¤ÖÁ¹ØÖØÒª¡£ ͼƬ ͼ 5. nub»ùÒòÔڵ¹úСó¹Öеıí´ïģʽ¼°Èô³æRNAi¸Ã»ùÒòºóµÄÓ°Ïì ×ÛÉÏËùÊö£¬ÕâЩ½á¹û±íÃ÷£¬Br¨CC¶Ô¡°Òí³¡¡±µÄ½¨Á¢²¢Ã»ÓÐÌØÒìÐԵűÏ×£¬µ«ÔÚËæºóµÄ³á°ò·¢Óý¹ý³ÌÖУ¬ËüËÆºõȷʵºÜÖØÒª£¬¿ÉÒÔÔöÇ¿³á°òÏà¹Ø»ùÒòµÄ±í´ï£¬ÓÈÆäÊÇnub¡£ ÕâÖ§³ÖÁËBr¨CC¿ÉÄÜ´Ù½øÁËÈ«´úлµÄ½ø»¯¡£È»¶ø£¬ºÁÎÞÒÉÎÊ£¬ÆäËûÒòËØÒ²´Ù³ÉÁËÕâÒ»Ñݱ䡣 ÔÎÄÁ´½Ó£º https://doi.org/10.1016/j.ibmb.2022.103798 |
» ²ÂÄãϲ»¶
»¯Ñ§¹¤³Ì£¬±¾211£¬Çóµ÷¼Á£¬abÇø²»ÏÞ
ÒѾÓÐ4È˻ظ´
ºþ±±Ê¦·¶´óѧÕе÷¼ÁÀ²
ÒѾÓÐ9È˻ظ´
»¯Ñ§¹¤³Ì¼°¹¤Òµ»¯Ñ§ÂÛÎÄÈóÉ«/·ÒëÔõôÊÕ·Ñ?
ÒѾÓÐ95È˻ظ´
ÉÛÑôѧԺʳƷÓ뻯ѧ¹¤³ÌѧԺ˶ʿµ÷¼Á
ÒѾÓÐ0È˻ظ´
Ìì½òÉÌÒµ´óѧ ÉúÎïÓëÒ½Ò©¿ÎÌâ×éÕÐÉú
ÒѾÓÐ0È˻ظ´
ÉúÎﻯ¹¤Ñ§Ë¶ÕÐÊÕµ÷¼Á
ÒѾÓÐ0È˻ظ´
¹ã¶«Ê¯ÓÍ»¯¹¤Ñ§Ôº2026Äê˶ʿÑо¿ÉúÐèÒª¶àÃûÉúÎï£¬ÖÆÒ©¹¤³Ì£¬Ê³Æ·×¨ÒµµÄµ÷¼ÁÉú
ÒѾÓÐ0È˻ظ´
»¯¹¤É격
ÒѾÓÐ3È˻ظ´
É격×Ô¼ö
ÒѾÓÐ2È˻ظ´














»Ø¸´´ËÂ¥