Znn3bq.jpeg
ÉÇÍ·´óѧº£Ñó¿ÆÑ§½ÓÊܵ÷¼Á
²é¿´: 512  |  »Ø¸´: 0

guying03

Ìú¸Ëľ³æ (СÓÐÃûÆø)

[½»Á÷] µÂ¹úСó¹µÄBr¨CC¸´ºÏÌåºÍ³á°ò·¢ÓýÑо¿

µÂ¹úСó¹µÄBr¨CC¸´ºÏÌåºÍ³á°ò·¢ÓýÑо¿



ÔÚ°ë±ä̬À¥³æÖУ¬×ªÂ¼Òò×ӹ㷺¸´ºÏÎBr¨CC£©´Ù½øÈô³æÆÚµÄ³á°òÉú³¤ºÍ·¢Óý¡£¸ÃÑо¿ÒԵ¹úСó¹ÎªÄ£ÐÍ£¬Ì½ÌÖBr¨CCÊÇ·ñÄÜÆô¶¯³á°òµÄ·¢Óý¡£



½á¹û±íÃ÷£¬Ò»ÁäÈô³æÔÚÕâÈý¸öÐØ¶ÎÖÐÓÐÆä¶ÀÌØµÄÉí·Ý¡£ÔÚÅßÌ¥·¢Éú¹ý³ÌÖУ¬Br¨CCºÍһЩ³á°òÏà¹Ø»ùÒòµÄ±í´ï³ÊÏÖÁ½¸öÆ¥Å䲨¡£µÚÒ»´Î·¢ÉúÔÚÅßÑ¿´øÐγÉ֮ǰ£¬Õâ¿ÉÄÜÉæ¼°½¨Á¢¸÷ÖÖ·¢ÓýÁìÓò£¬°üÀ¨Ç±Ôڵġ°³á°òÁìÓò¡±£¬µÚ¶þ´Î·¢ÉúÔÚÆ÷¹Ù·¢ÉúÖÜΧ£¬¿ÉÄÜÉæ¼°³á°ò·¢ÓýµÄÆô¶¯¡£

ͼƬ


ͼ 1. Broad¸´ºÏÎBr¨CC£©ºÍ³á°òÏà¹Ø»ùÒòµÄ±í´ï



È»¶ø£¬Br¨CCÔÚÔçÆÚÅßÌ¥·¢ÓýÖеıí´ï¼¯ÖÐÔÚ·¢ÓýÖеÄÖÐÊàÉñ¾­ÏµÍ³£¬Òò´ËÓëµäÐ͵ijá°òÏà¹Ø»ùÒò²ÐÓà»ùÒòµÄ±í´ï²»¹²¶¨Î»£¬¸Ã»ùÒò±í´ïÔÚÐØ¶ÎºÍ¸¹¶ÎµÄ±ßÔµ¡£Õâ±íÃ÷Br¨CCÔÚÔçÆÚÅßÌ¥·¢ÉúÖв¢²»Ìرð²ÎÓëDZÔÚ¡°Òí³¡¡±µÄ½¨Á¢¡£

ͼƬ


ͼ 2. ԭλÔÓ½»£¨ISH£©Ôڵ¹úСó¹ÅßÌ¥Öж¨Î»Ëùѡת¼±¾


´ËÍ⣬Br¨CCµÄĸÌåRNAiºÄ¾¡ÁËBr¨CC±í´ïµÄµÚÒ»²¨£¬µ«²»Ó°Ïì³á°òÏà¹Ø»ùÒòµÄÔçÆÚ±í´ï¡£ÓÉÓÚĸÌåBr¨CC RNAiûÓкľ¡Br¨CCµÄµÚ¶þ¸ö±í´ï²¨£¬ÎÒÃÇÎÞ·¨ÆÀ¹ÀBr¨CCÊÇ·ñ²ÎÓë³á°ò·¢ÓýµÄÆô¶¯¡£

ͼƬ



ͼ 3. ĸÌåRNAi¶ÔµÂ¹úСó¹Br¨CC¸´ºÏÎïºÍ³á°ò·¢ÓýÏà¹Ø»ùÒò±í´ïµÄÓ°Ïì



ÀûÓÃRNAiÒÖÖÆÈô³æBr¨CCºÍScrµÄ±í´ï£¬±íÃ÷Br¨CCÓÐÖúÓÚÐγÉÒìλ³á°ò½á¹¹£¬µ±Scr¼õÉÙʱ£¬ÕâЩ½á¹¹ÔÚÇ°ÐØ·¢Óý¡£



ͼƬ

ͼ 4. RNAiÒÖÖÆBr¨CCºÍScr¶ÔµÂ¹úСó¹³á°òÏà¹Ø»ùÒò±í´ïºÍÇ°ÐØ±íÐ͵ÄÓ°Ïì



ÊÜBr¨CC RNAiÓ°Ïì×îÃ÷ÏԵĻùÒòÊÇnubbin£¨nub£©£¬ËüÔÚÈô³æÖжԳá°òÉú³¤ÖÁ¹ØÖØÒª¡£

ͼƬ

ͼ 5. nub»ùÒòÔڵ¹úСó¹Öеıí´ïģʽ¼°Èô³æRNAi¸Ã»ùÒòºóµÄÓ°Ïì



×ÛÉÏËùÊö£¬ÕâЩ½á¹û±íÃ÷£¬Br¨CC¶Ô¡°Òí³¡¡±µÄ½¨Á¢²¢Ã»ÓÐÌØÒìÐԵűÏ×£¬µ«ÔÚËæºóµÄ³á°ò·¢Óý¹ý³ÌÖУ¬ËüËÆºõȷʵºÜÖØÒª£¬¿ÉÒÔÔöÇ¿³á°òÏà¹Ø»ùÒòµÄ±í´ï£¬ÓÈÆäÊÇnub¡£



ÕâÖ§³ÖÁËBr¨CC¿ÉÄÜ´Ù½øÁËÈ«´úлµÄ½ø»¯¡£È»¶ø£¬ºÁÎÞÒÉÎÊ£¬ÆäËûÒòËØÒ²´Ù³ÉÁËÕâÒ»Ñݱ䡣



Ô­ÎÄÁ´½Ó£º

https://doi.org/10.1016/j.ibmb.2022.103798
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ guying03 µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ÉúÎïѧ308·ÖÇóµ÷¼Á£¨Ò»Ö¾Ô¸»ª¶«Ê¦´ó£©½ÓÊÜ¿çרҵ +8 ÏàÐűػá¹ââÍòÕ 2026-04-13 8/400 2026-04-13 20:26 by biomen
[¿¼ÑÐ] 310Çóµ÷¼Á +14 666ÕæºÃ 2026-04-11 16/800 2026-04-13 16:44 by 89436494
[¿¼ÑÐ] Ò»Ö¾Ô¸Î÷½»»úеר˶Çóµ÷¼Á +9 ÇóÉϰ¶µÄСÍõ 2026-04-10 9/450 2026-04-13 16:08 by jiangguiquan11
[¿¼ÑÐ] Ò»Ö¾Ô¸ÖÐÄÏ´óѧ 0855 »úе 286 Çóµ÷¼Á +10 ²»»á³ÔÈâ 2026-04-12 10/500 2026-04-12 22:51 by ÁãÁã¶þ
[¿¼ÑÐ] 22408 352·ÖÇóµ÷¼Á +5 ŬÁ¦µÄÏÄÄ© 2026-04-09 5/250 2026-04-12 19:17 by wj165256
[»ù½ðÉêÇë] ɽ¶«Ê¡»ù½ð2026 +5 jerry681 2026-04-08 6/300 2026-04-12 08:33 by kudofaye
[¿¼ÑÐ] Çóµ÷¼Á£¬262»úеר˶ +8 àÅyyl 2026-04-08 8/400 2026-04-12 02:31 by Çï¶¹²ËÑ¿
[¿¼ÑÐ] 316Çóµ÷¼Á +5 Ïë¶ÁÑо¿Éú( ?¡ß 2026-04-07 5/250 2026-04-12 00:43 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 293Çóµ÷¼Á +6 ÓÂÔ¶¿â°®314 2026-04-08 6/300 2026-04-11 10:08 by zhq0425
[¿¼ÑÐ] »¯Ñ§¹¤³ÌÓë¼¼Êõ324µ÷¼Á +23 Ëï³£»ª 2026-04-09 25/1250 2026-04-11 00:07 by ÆïÅ£¶Éº®½­
[¿¼ÑÐ] 289 ·Ö105500ҩѧר˶Çóµ÷¼Á(ÕÒBÇøÑ§Ð£) +6 °×ÔÆ123456789 2026-04-09 8/400 2026-04-10 21:13 by zhouxiaoyu
[¿¼ÑÐ] 309Çóµ÷¼Á +14 wdhw 2026-04-10 15/750 2026-04-10 21:06 by zhouxiaoyu
[¿¼ÑÐ] 293µ÷¼Á +25 yj1221 2026-04-08 26/1300 2026-04-10 15:02 by ²ñС°×
[¿¼ÑÐ] 282£¬µçÆø¹¤³Ìרҵ£¬Çóµ÷¼Á£¬²»Ìôרҵ +9 jggshjkkm 2026-04-10 9/450 2026-04-10 14:55 by ÄæË®³Ë·ç
[¿¼ÑÐ] »úе»¹Óл¹ÓÐÃû¶îÂð£¿Ì«ÄÑÁË +6 ЦЦԬ 2026-04-10 6/300 2026-04-10 11:54 by ¸ßά´º
[¿¼ÑÐ] 085501»úеӢ¶þ77×Ü·Ö294Çóµ÷¼Á£¬½ÓÊÜ¿çרҵѧϰ +6 ÊØ·¨¹«ÃñØÁ¼Í 2026-04-08 6/300 2026-04-09 15:55 by wp06
[¿¼ÑÐ] 328Çóµ÷¼Á +17 lftmya 2026-04-07 18/900 2026-04-09 08:05 by 5268321
[¿¼ÑÐ] ÉúÎïѧѧ˶£¬³õÊÔ351·Ö£¬Çóµ÷¼Á +4 ¡­¡«¡¢Íõ¡­¡« 2026-04-08 5/250 2026-04-08 21:49 by limeifeng
[¿¼ÑÐ] Çó¿¼ÑвÄÁϵ÷¼Á +3 ²Ä»¯Àî¿É 2026-04-07 3/150 2026-04-08 00:21 by JourneyLucky
[¿¼ÑÐ] 325 µ÷¼Á +6 QQСϺ 2026-04-07 6/300 2026-04-07 15:17 by Ccclqqq
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û