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ls_2018新虫 (小有名气)
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美国国立卫生研究院（NIH）国家肿瘤中心（NCI）Chengkai Dai实验室招聘博后
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美国国立卫生研究院（NIH）国家肿瘤中心（NCI）Chengkai Dai实验室招聘博后 热烈欢迎有兴趣的同仁加入！ Position Title: Elucidation of proteomic instability in cancer and the role of HSF1 in enabling oncogenesis. Position Description: Dr. Chengkai Dai’s laboratory at the Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI), USA has one postdoctoral fellowship (visiting fellow) position open. The candidates will participate in projects that elucidate proteomic instability of cancer and tumor-associated amyloidogenesis, new phenomena in cancer biology, and investigate the multifaceted pro-oncogenic roles of heat shock factor 1 (HSF1). HSF1, the master transcriptional regulator of the heat-shock or proteotoxic stress, response, plays a critical role in preserving proteomic stability under stress conditions. Contrasting with its dispensability for primary cells, cancerous cells become dependent on HSF1, a phenomenon referred to as “non-oncogene addiction”. Revealed by Project Achilles, numerous human cancer cell lines depend on HSF1. Dr. Dai’s laboratory is conducting interdisciplinary research in the emerging field of proteomic instability of cancer. His recent research reveals that amyloidogenesis, due to disruption of proteome homeostasis, is tumor-suppressive and that HSF1 plays a critical role in repressing amyloidogenesis (Cell. 2015, 160:729-44; Nature Cell Biology. 2016, 18:527-39; Molecular Cell. 2019, 76:546-561; Science Advances. 2020, 6:eabc6871). Detailed information about Dr. Dai’s research and publications can be accessed at https://ccr.cancer.gov/staff-directory/chengkai-dai. Candidates for the postdoctoral fellowship may have up to 4 years of postdoctoral training experience. NCI offers an outstanding environment for training and career development. Postdoctoral trainees in Dr. Dai’s lab have successfully competed for NCI career transition awards and secured independent faculty positions. Applications, sent by e-mail to Dr. Dai (chengkai.dai@nih.gov), Phone (301) 846-5227, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information of three references. Employer Name: Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, NIH, DHHS. Position Location: National Cancer Institute – Frederick, Frederick, MD 21702 These positions are subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. |
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