| 查看: 670 | 回复: 0 | |||
godgoodstudy木虫 (小有名气)
|
[交流]
法国Cea博后职位, Synthesis of biomimetic copper complexes(4月30号截止)
|
|
title: synthesis of biomimetic copper complexes to understand the role of met-rich domains in copper homeostasis. location: symmes laboratory at cea-grenoble, france (https://www.symmes.fr/cibest) keywords: organic chemistry, bioinorganic chemistry, copper expected starting date: september 1st, 2022 at the latest application deadline: april 30th, 2022 project: the postdoctoral fellow will be involved in the metcop project, which associates chemists, biochemists and geneticists from the symmes laboratory in grenoble and the bip and lcb laboratories in marseille. we aim at determining the role of methionine-rich domains in the strategies adopted by microorganisms to tackle copper stress in various environments, with a particular focus on met-rich domains in cueo(-like) proteins. these met-rich domains exhibit diverse copper-binding sites, which respective contributions are challenging to identify. to disentangle this, we propose a small-molecule, peptidomimetic approach. the symmes laboratory has a strong experience in cu+ binding in biology[1,2] and previously demonstrated that the extracellular cu+ binding site of the cu transporter ctr1 could be modelled with a pseudopeptide containing three met residues.[3] using a similar approach, the postdoctoral fellow will design, synthesize and characterize small-molecule models that reconstitute copper binding environments in met-rich domains. key parameters will be evaluated, such as copper affinity or redox potential of cu2+/cu+ complexes, using a wide range of experimental methods (ms, nmr, epr, etc.) profile: we are looking for a highly motivated candidate having a phd in organic chemistry, bioinorganic chemistry or chemical biology, and a strong interest in the chemistry/biology interface. to apply, please send a cv, a motivation letter and two contacts able to provide a recommendation letter to dr sarah hostachy (sarah.hostachy@cea.fr) and dr pascale delangle (pascale.delangle@cea.fr). references: [1] m. monestier, a. m. pujol, a. lamboux, m. cuillel, i. pignot-paintrand, d. cassio, p. charbonnier, k. um, a. harel, s. bohic, c. gateau, v. balter, v. brun, p. delangle, e. mintz, metallomics 2020, 12, 1000╟1008. [2] a. m. pujol, c. gateau, c. lebrun, p. delangle, j. am. chem. soc. 2009, 131, 6928╟6929. [3] a.-s. jullien, c. gateau, c. lebrun, p. delangle, inorg. chem. 2015, 54, 2339╟2344. |
回复此楼» 猜你喜欢
不自信的我
已经有11人回复
-
北核录用
已经有3人回复
-
要不要辞职读博？
已经有6人回复
-
实验室接单子
已经有3人回复
-
磺酰氟产物，毕不了业了！
已经有8人回复
-
求助:我三月中下旬出站，青基依托单位怎么办？
已经有10人回复
-
26申博（荧光探针方向，有机合成）
已经有4人回复
-
论文终于录用啦！满足毕业条件了
已经有26人回复
-
2026年机械制造与材料应用国际会议 （ICMMMA 2026）
已经有4人回复
-
Cas 72-43-5需要30g，定制合成，能接单的留言
已经有8人回复
