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ÕÐÆ¸Ã÷ϸ position details postdoctoral positions in synthesis of oligosaccharides and sulfate oligosaccharides at wayne state university, detroit, michigan two postdoctoral positions are available in the laboratory of professor hien nguyen in the department of chemistry at wayne state university for candidates with expertise in the chemical synthesis of oligosaccharides and sulfated oligosaccharides. the goals of the project are (1) to prepare panels of oligosaccharides to examine their capacity as vaccine adjuvants; (2) to prepare panels of sulfated oligosaccharides to examine their ability as potent inhibitors of heparanase and sars-cov-2 spike protein as well as to evaluate their ability to prevent p-tau-elicited neurotoxicity for potential treatment of alzheimer¡¯s disease. the ultimate aim is to develop carbohydrate-based therapeutics for various diseases. position requirements £¨ÆäʵÓнϺõĺϳɾÑé¾Í¿ÉÒÔÁË£¬·¢ËͼòÀú°É£© ph.d. degree in organic chemistry, chemical biology, or medicinal chemistry with extensive experience in organic synthesis and/or carbohydrate synthesis, including an ability to identify target carbohydrates of biological importance as well as to design and employ chemical syntheses to obtain these compounds. experience with various spectroscopic technologies including nmr and mass spectrometry for organic compounds characterization is essential. expertise in binding assays is also essential. interested candidates should contact: professor hien nguyen department of chemistry wayne state university 5101 cass avenue detroit, mi 48202, usa hmnguyen@wayne.edu ¿ÎÌâ×é¼ò½é£º hien m nguyen carl johnson/pfizer professor of organic chemistry, wayne state university hien m nguyen, wayne state university ½²Ï¯½ÌÊÚ¡£1996Äê±¾¿Æ±ÏÒµÓÚtufts university, µ¼Ê¦Îªmarc d¡¯alarco½ÌÊÚ£¬2003Ä격ʿ±ÏÒµÓÚuniversity of illinois at urbana-champaign£¬Ê¦´Ódavid gin½ÌÊÚ¡£2003 ¨c 2006ÄêÔÚstanford university½øÐв©Ê¿ºóÑо¿£¬µ¼Ê¦Îªbarry trost½ÌÊÚ¡£nguyen½ÌÊÚ2009Äê¼ÓÈëuniversity of iowa£¬²¢ÓÚ2013Äê»ñµÃÖÕÉí½ÌÖ°£¬ÉýÈθ±½ÌÊÚ¡£2018Ä꣬nguyen½ÌÊÚÒÔcarl johnson professor of chemistry½²Ï°½ÌÊÚÉí·Ý¼ÓÈëwayne state university»¯Ñ§Ïµ£¬¹¤×÷ÖÁ½ñ¡£nguyen½ÌÊÚÒѾÔÚj. am. chem. soc., angew. chem. int. ed., chem. sci.,acs cata. µÈȨÍþÔÓÖ¾ÉÏ·¢±íÎÄÕ£¬²¢»ñµÃ¶à¸ö½±Ïî¡£¿ÎÌâ×éÑо¿Ìõ¼þÒ»Á÷£¬¾·Ñ³ä×㣬ĿǰÒÔpiÉí·ÝÖ÷³ÖnihÔÚÑÐÏîÄ¿4Ïî¡£ ¿ÎÌâ×éÁ´½Ó£º https://s.wayne.edu/nguyengroup/ Ñо¿·½Ïò the research program in the laboratory of professor nguyen lies at the crossroads of organic chemistry, chemical biology, organocatalysis, and transition-metal catalysis. the broad goals of our group are (1) to design and synthesize sulfated oligosaccharides and multivalent carbohydrate molecules (glycopolymers) as potent inhibitors of heparanase for treatment of cancers; (2) to design and synthesize heparan sulfate-like oligosaccharides and glycopolymers to inhibit sars-cov-2 virus-cell entry, thereby inhibiting progeny virus release from infected cell and spread; (3) to study saponin molecules as novel vaccine adjuvants for use in humans to combat a range of infectious diseases; (4) to develop carbohydrate molecules to control of hyperphosphorylated tau-mediated cell dysfunction and death; (5) to develop catalytic stereoselective glycosylation mediated by organocatalysts for the synthesis of bioactive oligosaccharides and glycopeptides; and (6) to investigate rhodium/iridium-catalyzed asymmetric allylic fluorination and amination as well as regioselective radio-fluorination for potential use as pet radiotracers. overall, all of the research projects are target candidates for therapeutic drugs and pet radiotracers [ last edited by xhf402 on 2022-3-5 at 16:33 ] [ last edited by xhf402 on 2022-3-5 at 16:35 ] |
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