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1.1 »ÆóÙ»ÔÑо¿Ô±¿ÎÌâ×飺
»ÆóÙ»Ô²©Ê¿£¬ÖÐɽ´óѧµÚÆ߸½ÊôÒ½Ôº¿ÆÑÐÓë¹ú¼Ê½»Á÷ÖÐÐÄÑо¿Ô±¡¢½ÌÊÚ¡¢²©Ê¿Éúµ¼Ê¦¡£ÖÐɽ´óѧº£Íâ¸ß²ã´ÎÒý½øÈ˲š£ÔÃÀ¹úҽѧ¿ÆѧԺ£¨NIH£©¶ùͯ½¡¿µÓëÈËÀà·¢Õ¹Ñо¿ËùÖúÀíÑо¿Ô±£¬ÏȺó»ñµÃÃÀ¹úŦԼ´óѧ (New York University) Àíѧ˶ʿ¡¢¿µÄζû´óѧ£¨Cornell University£©²©Ê¿Ñ§Î»£¬²¢ÔÚҮ³´óѧ(Yale University) Íê³É²©Ê¿ºóÅàѵ¡£Ê¦´Ó¿µÄζû´óѧҽѧԺ¸±Ôº³¤£¬Ï¸°ûÓë·¢ÓýÉúÎïѧϵϵÖ÷ÈÎKatherine A. Hajjar½ÌÊÚ£¬¼°Ò®Â³´óѧҩѧϵ¸±Ö÷ÈΣ¬Ñª¹ÜÉúÀíºÍÖÎÁÆÑо¿ÖÐÐÄÖ÷ÈÎWilliam Sessa½ÌÊÚ¡£ÏȺóÔÚScience, Nature Medicine, Nature Immunology, Journal of Clinical Investigation, BloodµÈ¸ßÓ°ÏìÒò×ÓѧÊõÆÚ¿¯·¢±íѧÊõÂÛÎÄ£¬²¢Ó¦Ñûµ£ÈÎFrontier in Oncology, Frontier in Immunology¿Í×ùÔðÈαà¼, ͬʱ»¹¼æÈÎCancer Immunology Immunotherapy, JCI insight, Cancer Letter, Tumor Biology, Journal of Surgical Oncology, Journal of CancerµÈѧÊõÔÓÖ¾Éó¸åÈË¡£¸ü¶àÏêÇ飬Çë²Î¿¼£ºhttp://www.sysush.com/content/6bb2b154-c325-42b0-a124-0c2ded3c62dd
1.2 ¿ÎÌâ×éÖ÷ÒªÑо¿·½ÏòÊÇ£¨µ«²»¾ÖÏÞÓÚ£©ÒÔÏÂÈý¸öÁìÓòµÄ¿ÎÌ⣺
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1.3´ú±íÐÔÂÛÎÄ
1£©Huang B, et al. (2022) Science Immunology (under revision) (IF=17.727)
2£©Huang B, et al. (2017). Nature Medicine 23(1):128-135 (IF=53.44)
3£©Huang B, et al. (2011). Blood 118(10): 2918-29. (IF=22.113)
4£©Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A. (2013). Science 342(6157):447-53. (IF=41.845)
5£©Hong P, Chen K, Huang B, Liu M, Cui M, Rozenberg I, Chaqour B, Pan X, Barton ER, Jiang X, Siddiqui MAQ (2012). Journal of Clinical Investigation 122(11): 3873-87. (IF=14.808)
6£©Chen K, Xu W, Wilson M, He B, Miller NW, Bengten E, Edholm E-S, Santini PA, Rath P, Chiu A, Cattalini M, Litzman J, Bussel J, Huang B, Meini A, Riesbeck K, Cunningham-Rundles C, Plebani A, Cerutti A (2009). Nature Immunology 10:889-898. (IF=25.606)
7£©Cesarman-Maus G, R¨ªos-Luna NP, Deora AB, Huang B, Villa R, Cravioto Mdel C, Alarc¨®n-Segovia D, S¨¢nchez-Guerrero J, Hajjar KA. (2006). Blood 107 (11): 4375-4382. (IF=22.113)
1.4 ÆäËü
±¾¿ÎÌâ×é2019Äê³ÉÁ¢£¬ÔÚ²»µ½3Äêʱ¼äÒÑ˳Àû»ñµÃ¹ú×ÔÈ»ÃæÉÏ»ù½ð2Ï¹ã¶«Ê¡ÇàÄê»ù½ð1ÏÉîÛÚÊÐÃæÉÏ»ù½ð2Ï¹ú¼Ò²©Ê¿ºó»ù½ð1Ïî×ÊÖú¡£Ä¿Ç°¿ÎÌâ×éÓв©Ê¿ºó1Ãû£¬²©Ê¿Ñо¿Éú6Ãû£¬Ë¶Ê¿Ñо¿Éú3Ãû£¬»¹½«Óë¹úÄÚÍâ¶àËùÖªÃûԺУºÍ¿ÆÑлú¹¹Èç¹þ·ð´óѧ¡¢Ò®Â³´óѧ¡¢¿µÄζû´óѧ¡¢NIH£¬ºÍ¶«¾©´óѧ¿ªÕ¹¹ã·ººÍÉîÈëµÄºÏ×÷£¬¹²Í¬Íƽø¿ÎÌâ½øÕ¹¡£¿ÎÌâ×é³ÉÔ±ÄêÇáÇÒÓлîÁ¦£¬±ü³Ð»îÁ¦¿ÆÑк͹«Æ½¹«ÕýµÄÔÔò£¬Õæ³ÏÏ£Íû¸÷λÓÐÖ¾ÇàÄê²Å¿¡¼ÓÃËÎÒÃÇÕâ¸öеļÒÍ¥£¬ÆÚ´ýÄúµÄµ½À´£¡
2.1 ¿µÑó¸±Ñо¿Ô±¿ÎÌâ×飺
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±¾¿ÎÌâ×éÑо¿·½ÏòΪÉúÎïҽѧÏȽø²ÄÁÏ£¬¾ßÌåÑо¿ÏȽø²ÄÁÏÔÚÖ×ÁöÃâÒß¡¢Ö×Áö¼ì²â¡¢Ö×ÁöÖÎÁÆ¡¢¿ÉÊÓ»¯¸øҩϵͳÖеÄÓ¦Ó᣽üÄêÀ´Ö÷Òª¹¤×÷¼¯ÖÐÓÚÐÂÐʹ̼¤ÏìÓ¦ÐÔÄÉÃ×µÝËÍÌåϵµÄ¿É¿Ø¹¹Öþ¼°¼²²¡ÕïÁÆÓ¦Óá£Ä¿Ç°ÀÛ»ý·¢±íÂÛÎÄ40Óàƪ£¬ÆäÖÐÒÔµÚÒ»×÷Õß/ͨѶ×÷Õß·¢±íÂÛÎÄ30Óàƪ¡£Ïà¹Ø³É¹ûÒÔµÚÒ»/ͨѶ×÷Õß·¢±íÔÚ¶¥¼¶Ñ§Êõ¿¯ÎïAdvanced Materials, Advanced Functional MaterialsµÈ¡£»¶Ó¾ßÓл¯Ñ§¡¢²ÄÁÏ¡¢ÉúÎҽѧ¡¢ÃâÒßµÈÏà¹Ø±³¾°µÄѧÉú¼ÓÃË¿ÎÌâ×飬Ҳ»¶Ó±¾Ð£±¾¿ÆÉú²ÎÓë¿ÎÌâÑо¿£¬É걨´óѧÉú´´Ð¼ƻ®£¬Íê³É±ÏÒµÂÛÎÄ¡£±¾¿ÎÌâ×é³£ÄêÕÐƸ²©Ê¿ºó£¬ÌṩÁ¼ºÃ¿ÆÑл·¾³¡£ÖÐɽ´óѧ¸½ÊôµÚÆßÒ½Ôº½üÄêÀ´·¢Õ¹Ñ¸ËÙ£¬ÓÅÐ㲩ʿºóÓнϴó»ú»áÁôÔº¼ÌÐø¹¤×÷¡£ÏêÇé²Î¿¼£ºhttp://www.sysush.com/content/7261bfe1-515d-4d07-825b-2d5687d85bcb
2.2 ½ü3Äê´ú±íÐÔÂÛÎÄ
1. Smart nanocarriers as therapeutic platforms for bladder cancer. Nano Research. 2021, https://doi.org/10.1007/s12274-021-3753-9. £¨IF£º8.897£©
2. Dual pH- and glutathione-responsive CO2-generating nanodrug delivery system for contrast-enhanced ultrasonography and therapy of prostate cancer. ACS Applied Materials & Interfaces. 2021, 13, 12899-12911. £¨IF£º9.229£©
3. Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. Materials Science & Engineering C, 2021, 123, 111956. £¨IF£º7.328£©
4. Engineered PD-L1-Expressing platelets reverse new-onset type 1 diabetes. Advanced Materials, 2020, 32, 1907692. £¨IF£º30.849£©
5. Nano drug carrier based on poly(ursolic acid) with self-anticancer activity against colorectal cancer. Advanced Functional Materials, 2020, 30, 1907857. £¨IF£º18.808£©
6. Redox-Responsive self-assembled nanoparticles for cancer therapy. Advanced Healthcare Materials, 2020, 2000605. £¨IF£º9.933£©
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