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【求助完毕】8金币帮忙修改一下英文摘要+3天
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聚乳酸硝苯地平缓释微球的制备与释药性能研究 摘要：以熔融缩聚制得的聚乳酸作为载体，以聚乙烯醇为分散剂，二氯甲烷为溶剂，采用乳化-溶剂蒸发法制备聚乳酸硝苯地平缓释微球。通过红外光谱( FT-IR)和BK-1000生物显微镜对聚乳酸硝苯地平缓释微球进行了表征，并用紫外分光光度法探讨了聚乳酸硝苯地平缓释微球的释药性能。结果表明：聚乳酸硝苯地平缓释微球呈现以光滑完整的球形，且聚乳酸和硝苯地平药物能够有机地结合为一体。合成的聚乳酸硝苯地平球形微球具有明显的缓释作用，而且增大硝苯地平/聚乳酸投药比，会提高微球的释放度，但包封率下降。 关键词：聚乳酸；硝苯地平；溶剂蒸发法；微球；药物缓释 Preparation and Drug-releasing Performance of Polylactic Acid/ Nifedipine Sustained-release Microspheres Abstract: The polylactic acid(PLA) was used as a drug carrier,which was synthesized by the direct melting polycondensation method.PLA / Nifedipine (NFD) microspheres were prepared by the solvent evaporation method.The methylene chloride was chosen as a good solvent and poly vinyl alcohol（PVA）was adopted as a dispersed agent.Polylactic acid /Nifedipine sustained-release microspheres were characterized by infrared spectroscopy (FT-IR) and BK-1000 biological microscope. The released property was examined by ultraviolet spectrophotometry.Experimental results showed that the products by this method had smooth spherical shapes,and Polyactic acid and Nifedipine can be organically combined as one.PLA/NFD microspheres synthesizehad had obvious sustained-release function.What′s more , increasing the ratio of NFD to PLA, released speed of Nifedipine was quickened,but entrapment rate was decreased. Keywords: Nifedipine; PLA; solvent evaporation method; controlled release [ Last edited by qingshaojun0823 on 2009-9-4 at 21:26 ] |
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2楼2009-08-27 16:03:58
pitlord999
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zc450zc(金币+4,VIP+0):谢谢啊 8-27 18:37
linghanyuan(金币+1,VIP+0):谢谢交流 8-27 22:54
zc450zc(金币+4,VIP+0):谢谢啊 8-27 18:37
linghanyuan(金币+1,VIP+0):谢谢交流 8-27 22:54
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写的不错，帮你改了几个小错误。注意标点和空格的用法。 Preparation and Drug-releasing Performances of Polylactic Acid/ Nifedipine Sustained-release Microspheres Abstract: Polylactic acid(PLA) was used as a drug carrier, which was synthesized via direct melting polycondensation method. PLA/Nifedipine (NFD) microspheres were prepared via solvent evaporation method.The methylene chloride was selected as a good solvent of ???, and poly vinyl alcohol（PVA）was adopted as a dispersed agent. Polylactic acid/Nifedipine sustained-release microspheres were characterized by infrared spectroscopy (FT-IR) and BK-1000 biological microscope. The released property was examined by ultraviolet spectrophotometry. Experimental results showed that products obtained using this method had smooth spherical shapes, and Polyactic acid and Nifedipine could be organically integrated into one ???. PLA/NFD microspheres synthesizehad exhibited obvious sustained-release functions. Moreover, increasing the ratio of NFD to PLA let to an accelerated released speed of Nifedipine and a decreased entrapment rate. Keywords: Nifedipine; PLA; solvent evaporation method; controlled release |
3楼2009-08-27 16:54:53
goodtimega
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zc450zc(金币+2,VIP+0):谢谢啊 哈哈 8-27 19:21
linghanyuan(金币+1,VIP+0):谢谢交流 8-27 22:54
zc450zc(金币+2,VIP+0): 8-28 10:39
zc450zc(金币+2,VIP+0):谢谢啊 哈哈 8-27 19:21
linghanyuan(金币+1,VIP+0):谢谢交流 8-27 22:54
zc450zc(金币+2,VIP+0): 8-28 10:39
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Preparation and Drug-releasing Performances of Polylactic Acid/ Nifedipine Sustained-release Microspheres Abstract: Polylactic acid (PLA) synthesized via direct melting polycondensation method is employed as a drug carrier. PLA/Nifedipine (NFD) microspheres were prepared via solvent evaporation method. The methylene chloride was chosen as a desired solvent and poly vinyl alcohol（PVA）was adopted as a dispersing agent. Polylactic acid /Nifedipine sustained-release microspheres were characterized by infrared spectroscopy (FT-IR) and BK-1000 biological microscope. The related property was examined by ultraviolet spectrophotometry. Experimental results showed that products obtained using this method had smooth spherical shapes, and Polyactic acid and Nifedipine could be organically integrated into one species. PLA/NFD microspheres synthesizehad exhibited obvious sustained-release functions. Furthermore, increasing the ratio of NFD to PLA leds to an accelerated released speed of Nifedipine and a decreased entrapment rate. Keywords: Nifedipine; PLA; solvent evaporation method; controlled release |
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