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Can you use the online system to convert the revision to PDF first? Then write/revise the response to reviewers.
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Manuscript File
The manuscript for publication may be submitted with graphics embedded in the text where they are discussed, placed at the end of the text, or left out of the text and submitted as separate files. Consult the Author Guidelines for the journal to which you are submitting for the Editor's requirements or preferences. Two File Designations are available for manuscript text; a variety of word-processing software is supported for these two File Designations.

Manuscript File: This file is required. It should contain your original manuscript text (graphics may either be embedded in the file or uploaded separately) and it should be created in an acceptable software format. Paragon Plus will automatically produce both a PDF and an HTML proof from this file for use during the peer review process.

Manuscript PDF File: This file is optional. Authors may choose to submit this file in addition to the Manuscript File, to facilitate the peer review process. If a Manuscript PDF File is uploaded, that file will be used as the PDF proof during the peer review process instead of the system-generated proof.

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