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[交流] 2022英国格拉斯哥大学-CSC公派：单分子荧光方法研究DNA的结构和动态

研究方向：使用单分子荧光方法研究DNA的结构和动态
研究课题：Single-molecule spectroscopy of DNA triplet repeat structures
学校：英国格拉斯哥大学
导师：Dr Steven Magennis
联系方式：steven.magennis@glasgow.ac.uk
截至日期：2022年1月31日
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PhD in Single-molecule spectroscopy of DNA triplet repeat structures

Supervisor: Dr. Steven Magennis (School of Chemistry, University of Glasgow, UK)

We discovered recently that the three-way DNA junctions formed when CAG or CTG repeats form a hairpin loop have conformational flexibility and undergo branchpoint migration [1]. The ability of these hairpin "slipouts" to migrate has implications for their reactivity and repair, and may be connected with the switch from healthy behavior to disease.

The PhD project will investigate the role of repeat sequence and length on DNA dynamics and would test the ability of small molecules, as potential drug candidates, to alter these dynamics. It would also look at interactions of DNA with DNA repair proteins, which are implicated in the expansion process.

The University of Glasgow will waive the international fees of successful Chinese applicants, and will support their personal applications for CSC Scholarships. Full formal applications must be submitted online by 31st January 2022, including two letters of reference and a personal statement (no research proposal is necessary). If you are interested, please email Dr. Steven Magennis (steven.magennis@glasgow.ac.uk) with a CV (in English) as soon as possible. Full details are in the link below.

https://www.gla.ac.uk/colleges/scienceengineering/graduateschool/scholarships/chinascholarshipcouncil/

[1] Hu, T., Morten, M. J., and Magennis S. W. (2021) Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats, Nat. Commun., 12, 204

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