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巴黎心血管疾病研究中心招聘2022年CSC博士研究生
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巴黎心血管疾病研究中心（Paris Cardiovascular Disease Center）Nabila-BOUATIA-NAJI 组2022招聘CSC博士生 1. 研究所和实验室简介 巴黎心血管疾病研究所（PARCC）由巴黎大学（原巴黎大学医学部，生命科学和医学领域排名法国第一位，shanghai ranking 65）、欧洲乔治蓬皮杜医院和法国国家健康与医学研究院（INSERM）联合共建，是专业研究人类心血管疾病的研究中心。 Nabila研究组通过基因组学、遗传学以及流行病学对罕见血管疾病进行研究。肌纤维发育不良研究项目处于世界顶尖水平，拥有世界最大的基因数据（包括美国mayo研究所、英国、荷兰以及欧盟医院病患和非病患基因组数据）和高顶尖的基因组学技术，2017年获得欧盟研究委员会重点资金支持，研究成果进展显著。该研究课题不仅拥有涵盖对大量数据进行基因组学分析的最先进科研方法，而且生物信息学与细胞生物学连接紧密，对很多疾病的研究具有高度的借鉴性。 Nabila的H-index为55， 实验室详情和研究方向以及课题详见 https://nabilabouatianaji.fr/index.php/projects。课题组可拓展研究方向很多，很多遗传学和基因组学数据结果亟待验证或者深入研究，课题目前多方向，主要有基因组学分析，iPSC多功能诱导性干细胞分化等。老板人非常好，工作效率非常高，非常为学生发展考虑，课题组氛围也非常好。 2. 专业要求 具有或者即将获得分子生物学，细胞生物学硕士学位（主要要求有分子生物学和细胞生物学的实验经历，有iPSC培养经验者优先），如果有遗传学背景（genetics）或者生物信息背景更有优势。 工作语言为英语，能基本交流，有英文写作能力。 能够申请CSC博士项目，符合国家基金委要求。 3. 博士课题：血管疾病FMD和SCAD相关遗传位点的功能分析 Functional analyses of genetic loci associated to vascular diseases primarily affecting women Laboratory: Genetics to understand arterial disease – PARCC Inserm, Université de Paris Superviser: Nabila Bouatia-Naji, PhD, Team leader Co-superviser: Adrien Georges, PhD Cardiovascular diseases (CVD) represent a major and increasing burden on global health. Recent awareness that CVD may present with specific, often neglected, symptoms and etiology in women opened a new research field. Spontaneous coronary artery dissection (SCAD) is an acute coronary syndrome, often leading to myocardial infarction, characterized by the partial or complete occlusion of a coronary artery due to a dissection of the arterial wall. SCAD affects primarily young to middle-aged women without typical cardiovascular risk factors and its causes are presently unknown. We study the genetic basis of SCAD and related vascular diseases using genome-wide approaches such as genome-wide association study and exome-sequencing. Genetic variants identified so far are non-coding variants presumed to be involved in transcriptional regulation processes in arterial smooth muscle cells (SMCs) and fibroblasts. Our current aims are to understand the regulatory mechanisms at SCAD associated loci, identify the target genes and the context of this regulation, and determine what are the interactions of these loci with environmental factors such as sex hormones. To better understand these biological mechanisms, we use human induced pluripotent stem cells that we can genetically modify using CRISPR-Cas9 system and differentiate into SMCs harboring different phenotypes. To deeply characterize the phenotype of these cells, we commonly use high-throughput genomic and proteomic approaches such as ATAC-Seq, RNA-Seq, single-cell sequencing and mass spectrometry, together with cellular assays including video microscopy and intracellular probes. We are located in “Paris cardiovascular research center” (PARCC), a research center of excellence with international expertise on cardiovascular disease, strong links to the clinical facilities at Hôpital Georges Pompidou, and to many bio-informatics and genomics and transcriptomics facilities of Université de Paris. We are an international ad diverse team and we are deeply invested in offering the best conditions for doctoral researchers of any origin. Main recent publications: (*involving recent PhD students) • *Georges A, Yang ML, Berrandou TE, et al. "Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases” Nat Commun 12:6031. (2021) doi: 10.1038/s41467-021-26174-2. • *Yu M, Kyryachenko S, Debette S, et al. “Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.“ Circ Genom Precis Med. 14: e003148 (2021). doi: 10.1161/CIRCGEN.120.003148. • Amrani-Midoun A, Adlam D, Bouatia-Naji N. “Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection.” Circ Genom Precis Med. CIRCGEN121003393 (2021). doi: 10.1161/CIRCGEN.121.003393. • *Kyryachenko S, Georges A, Yu M, et al. “Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.” Circ Res. 128:e84-e101 (2021). doi: 10.1161/CIRCRESAHA.120.317581. • Georges A, Albuisson J, Berrandou T, et al. “Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia.” Cardiovasc Res. 117:1154-1165 (2021). doi: 10.1093/cvr/cvaa161. • *Yu M, Georges A, Tucker NR, et al. “Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse.” Circ Genom Precis Med. 12:e002497 (2019). doi: 10.1161/CIRCGEN.119.002497. • Adlam D, Olson TM, Combaret N, et al. “Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection.“ J Am Coll Cardiol. 73:58-66 (2019). doi: 10.1016/j.jacc.2018.09.085. 4. 联系方式 有意者且满足条件者，且可以申请CSC博士后奖学金者，请将简历（包括CV，两封推荐信）及动机信发送到老板邮箱nabila.bouatia-naji@inserm.fr |
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