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韦恩州立大学及 Karmanos 癌症研究所诚招博士后
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研究方向: 肿瘤微环境；肿瘤转移；免疫治疗及耐药性 起始时间: 2022年3月左右 （具体时间可协商） 应聘要求: 具有生物医学/肿瘤学/分子生物学 或者相关领域的博士学位。在生物信息学，肿瘤生物学，细胞生物学，或者免疫学相关领域有一作文章者优先。最好有一定的动物（小鼠）实验操作背景。有良好的英语写作和沟通能力。 有意向者请将英文自荐信（篇幅小于一页）和英文简历发送到 minhong.shen@wayne.edu 或 minhongshen86@gmail.com 简介： Postdoctoral positions are available for highly motivated candidates in Dr. Minhong Shen Lab at the Department of Pharmacology and Oncology, Wayne State University School of Medicine. The Shen Lab is also a member of the Tumor Biology and Microenvironment Program of the Barbara Ann Karmanos Cancer Institute (KCI) - a National Cancer Institute (NCI) designated comprehensive cancer center. Supported by the State-of-the-art facilities such as proteomics, genomics, flow cytometry, and imaging cores at the Wayne State University and KCI, the Shen Lab aims to understand the mechanisms underlying cancer metastasis and treatment resistance by focusing on tumor microenvironment (TME). The Lab is also trying to develop novel TME remodeling therapeutic strategies to potentially reduce cancer mortality by using multiple animal systems, including Genetically Engineered Mouse Models (GEMMs), patient-derived xenograft (PDX), multiple experimental metastases models, and syngeneic tumor models. 代表文章： Shen M., Wei Y., Kim H., Wan L., Jiang Y., Hang X., Raba M., Remiszewski S., Rowicki M., Zhang L., Lu X., Yuan M., Smith H., Zheng A., Lin H., Bertino J., Jin J., Xing Y., Shao Z., Kang Y. (2021) Therapeutic Targeting of the MTDH-SND1 Complex Suppresses Breast Cancer Progression and Metastasis. Nature Cancer. In press Shen M., Smith H., Wei Y., Jiang Y., Zhao S., Wang N., Rowicki M., Tang Y., Hang X., Wan L., Shao Z., Kang Y. (2021) Disruption of the MTDH-SND1 Complex Enhances Tumor Antigen Presentation and Sensitizes Metastatic Breast Cancer to Anti-PD-1 Therapy. Nature Cancer. In press. Shen M., Jiang YZ., Wei Y., Ell B., Sheng X., Esposito M., Kang J., Hang X., Zheng H., Rowicki M., Zhang L., Shih WJ., Celia-Terrassa T., Liu Y., Shao ZM., Crestea I., Kang Y. (2019) Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 35(1): 64-80. Shen M., Cai Y., Yan X., Yang Y., Zhou T. (2013) Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes. Cell Research 23:1284-1295 |
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