| 查看: 428 | 回复: 3 | |||
| 当前主题已经存档。 | |||
bioinfuture铁虫 (小有名气)
|
[交流]
急需一篇SCI文章，必有金币酬谢
|
||
|
1: Immunol Res. 1998;18(2):79-92.Links The optimization of helper T lymphocyte (HTL) function in vaccine development.Alexander J, Fikes J, Hoffman S, Franke E, Sacci J, Appella E, Chisari FV, Guidotti LG, Chesnut RW, Livingston B, Sette A. Epimmune Inc., San Diego, CA, USA. Helper T lymphocyte (HTL) responses play an important role in the induction of both humoral and cellular immune responses. Therefore, HTL epitopes are likely to be a crucial component of prophylactic and immunotherapeutic vaccines. For this reason, Pan DR helper T cell epitopes (PADRE), engineered to bind most common HLA-DR molecules with high affinity and act as powerful immunogens, were developed. Short linear peptide constructs comprising PADRE and Plasmodium-derived B cell epitopes induced antibody responses comparable to more complex multiple antigen peptides (MAP) constructs in mice. These antibody responses were composed mostly of the IgG subclass, reactive against intact sporozoites, inhibitory of schizont formation in liver invasion assays, and protective against sporozoite challenge in vivo. The PADRE HTL epitope has also been shown to augment the potency of vaccines designed to stimulate a cellular immune response. Using a HBV transgenic murine model, it was found that CTL tolerance was broken by PADRE-CTL epitope lipopeptide, but not by a similar construct containing a conventional HTL epitope. There are a number of prophylactic vaccines that are of limited efficacy, require multiple boosts, and/or confer protection to only a fraction of the immunized population. Also, in the case of virally infected or cancerous cells, new immunotherapeutic vaccines that induce strong cellular immune responses are desirable. Therefore, optimization of HTL function by use of synthetic epitopes such as PADRE or pathogen-derived, broadly crossreactive epitopes holds promise for a new generation of highly efficacious vaccines. |
回复此楼» 猜你喜欢
哪位老哥知道今年的国自然具体哪一天放榜？
已经有9人回复
-
欢迎发来filecode的Mz6后的代码验证其规律
已经有72人回复
-
咱们一起用铁证分析2026国家社科基金中标与否
已经有26人回复
-
我的国基提前知道中了，可是同事的操作让我实在接受不了，怎么会有这样的人
已经有16人回复
-
有时候，自然基金真的不能太认真 （我的申报经验）
已经有12人回复
-
招聘 金属平磨液，抛光液研发工程师
已经有3人回复
-
时间戳又变了8-15
已经有23人回复
-
filecode=后面第一个是大写字母
已经有7人回复
-
filecode
已经有12人回复
-
小木虫上这么多卖论文的，真有人买论文么？感觉没必要啊
已经有13人回复
houjinglhy
荣誉版主 (文坛精英)
表达自由，人权之基。
- BioEPI: 1
- 应助: 21 (小学生)
- 贵宾: 0.911
- 金币: 5168.5
- 散金: 3205
- 红花: 137
- 沙发: 93
- 帖子: 10564
- 在线: 913.2小时
- 虫号: 461324
- 注册: 2007-11-18
- 专业: 生物技术药物
- 管辖: 公派出国
★ ★ ★ ★ ★
bioinfuture(金币+5,VIP+0):xiexie 8-21 14:48
bioinfuture(金币+5,VIP+0):xiexie 8-21 14:48
2楼2009-08-21 00:05:18
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
bioinfuture(金币+15,VIP+0): 8-21 14:49
bioinfuture(金币+15,VIP+0): 8-21 14:49
| 已发送至你的邮箱shengmingbuxi@yahoo.com.cn。 |
3楼2009-08-21 14:45:41
zhangtangw
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 3192.7
- 帖子: 106
- 在线: 43.5小时
- 虫号: 586366
- 注册: 2008-08-15
- 性别: GG
- 专业: 食品加工学基础
4楼2009-08-30 16:41:11
