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北京石油化工学院2026年研究生招生接收调剂公告
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[求助] HNL文献摘要翻译

Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria
Abstract
We have earlier indicated neutrophil activation in severe malaria by measuring myeloperoxidase (MPO) and
lysozyme, leukocyte granule proteins secreted by neutrophils as well as by other blood cells (monocytes/macrophages).
In this study we evaluated the plasma levels of human neutrophil lipocalin (HNL), a specific neutrophil granule protein,
in relation to previously reported markers MPO and lysozyme, for clinical significance in indicating severe malaria. For
this purpose, plasma samples were analyzed from 65 individuals with severe malaria, mild malaria or malaria negative,
all living in the Gedarif area of Sudan. The plasma levels of HNL were significantly higher in the group of patients with
severe malaria as compared with the other two groups. Plasma levels of HNL correlated significantly to those of MPO
and lysozyme, as well as to body temperature, degree of parasitaemia and pulse rate. These results confirm our previous
findings that neutrophils are activated in-patients with severe malaria and the level of HNL is a good marker in this
context

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