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HNL相关文献翻译
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Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections Human neutrophil lipocalin (HNL) is a recently identified protein from human neutrophil granules. The concentrations of HNL in the circulation were measured, in a group of patients with acute infections, using a radioimmunoassay. The concentrations of HNL in patients infected by viruses and bacteria were 93.78f45.30 pg I-' (SD), 404.14+_355.02 pg 1-' (SD) in serum, and 47.81 f 18.18 pg 1-' (SD), 145.46+ 194.32 pg 1-' (SD) in plasma, respectively. The differences between the two patient groups were highly significant. There was a significant correlation between serum HNL and plasma HNL levels in bacterial infections (r =0.73, p <0.0001). The HNL serum levels also correlated with those of C-reactive protein, (CRP) (r = 0.59, p < 0.0001). Determination of HNL in serum was more specific and sensitive than CRP in the distinction between viral and bacterial infections. At a cut-off of 155 pg 1-' (HNL in serum), the positive and negative predictive values for the diagnosis of bacterial infections were 92 and 96%, respectively, which were superior to the optimal predictive values of CRP. Thus, the determination of HNL level is useful in the diagnosis of acute bacterial infections. |
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