| 查看: 353 | 回复: 0 | ||
| 【悬赏金币】回答本帖问题，作者就一个字拽将赠送您 10 个金币 | ||
[求助]
Synthesis and a-glucosidase inhibitory activity ofchrysin, diosmetin,
|
||
|
Abstract Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The glucosidase inhibitory activity of all derivatives (IC50 < 24.396 μmol/L) was higher compared with that of the reference drug, acarbose (IC50 = 563.601 ± 40.492 μmol/L), and 1-deoxynojirimycin (IC50 = 226.912 ± 12.573 μmol/L). O3′,O7-Hexyl diosmetin (IC50 = 2.406 ± 0.101 μmol/L) was the most potent inhibitor identified. These compounds showed a higher inhibitory ability compared with their precursors except the luteolin derivatives. In general, the inhibitory activity of the synthetic derivatives was enhanced with long alkyl chains at positions 3′, 4′ and 7 of the flavonoid. Graphical abstract Twelve novel α-glucosidase inhibitors were synthesized and all derivatives showed remarkable inhibitory activity against α-glucosidase with potency better than that of acarbose and 1-deoxynojirimycin |
回复此楼» 猜你喜欢
一志愿武理材料工程348求调剂
已经有7人回复
-
306求调剂
已经有6人回复
-
一志愿上海交大生物与医药专硕324分，求调剂
已经有3人回复
-
求调剂一志愿海大，0703化学学硕304分，有大创项目，四级已过
已经有9人回复
-
289材料与化工（085600）B区求调剂
已经有4人回复
-
08工科 320总分 求调剂
已经有11人回复
-
一志愿华中农业071010，总分320求调剂
已经有6人回复
-
323求调剂
已经有5人回复
-
284求调剂
已经有5人回复
-
317求调剂
已经有16人回复
