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Thank you for submission of your paper to Cell Reports. I have included the comments that reviewers made on your paper, which I hope you will find useful and constructive. As you will see, the overall view is that the study is potentially interesting, but the recommendation is against publication of the paper in the current form in Cell Reports and we have therefore closed the submission.

That said, the reviewers do make suggestions for further experiments and analyses that might guide the paper toward being a stronger candidate for the journal. In particular, we would need a more developed mechanism and more physiologically relevant system to consider publication in Cell Reports.

If you are interested in pursuing further consideration of this work at Cell Reports, you would first need to submit a point-by-point response that outlines how you might be able to address the reviewer concerns, and outlines how any corresponding results and/or edits would be incorporated into a revised manuscript. We would then assess the plan for revision, possibly in consultation with the reviewers. Based on these considerations, we would either reactivate the manuscript file to enable resubmission, or reiterate our decision to reject the paper.

I know that this outcome is disappointing, given the hard work that you and your colleagues have put into the paper. I hope that the reviewers' comments will be useful to you as you consider next steps, and I hope that you will consider Cell Reports for future submissions as your interesting work progresses.
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