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南方科技大学公共卫生及应急管理学院2026级博士研究生招生报考通知（长期有效）

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Chengxm

至尊木虫 (职业作家)

应助: 11 (小学生)
金币: 10747.2
红花: 3
帖子: 3637
在线: 371.9小时
虫号: 249332
注册: 2006-05-06
性别: GG
专业: 化学生物学与生物有机化学

[交流] 新加坡国立大学有机博士后机会

老板在国大化学系和生物系都有实验室，还有药物化学项目，基金多，实验条件很好，在学术上要求比较严格。希望有机合成经验丰富，能吃苦的博士做博士后，或者硕士可以做研究助理。博士工资最低3500新币（1新币＝4.7 人民币，现在汇率较低，一般在5左右），干得好可以增加。

Associate Professor YAO SHAO QIN
(Dean's Chair Professor)
Research Interests

Organic & Bioorganic Chemistry/Chemical Biology

Research program in my group is directed towards the interface of organic chemistry and molecular biology/cell biology, namely chemical biology and chemical genetics. We are interested in designing, identifying, synthesizing and studying biologically interesting molecules, which include small molecules and natural products, peptides and their analogs, as well as natural and unnatural proteins. Current research projects center around the following areas:

(1) Combinatorial Chemistry & Organic Synthesis. By utilizing combinatorial approaches, we are synthesizing libraries of small molecules that possess novel fluorescent properties. We are also exploiting the possibility of making encoded small molecule and peptide-based libraries suitable to make the corresponding, addressable microarrays. Other interests include developing one-bead, two-compound strategies for high-throughput screening (HTS) of peptide and non-peptide protease (and other enzymes) inhibitors, as well as developing combinatorial approaches towards novel chiral catalysts.

(2) De Novo Peptide & Protein Design. Both rational design and combinatorial approaches (semi-rational/irrational) are being utilized in our group to design peptides and proteins that possess novel properties in their folding and chemical activities, etc. For example, can functional proteins composed of less than the 20 naturally occurring amino acids (i.e. 15 AA) exist? Techniques that we use include phage display, DNA shuffling, cloning, protein expression, solid-phase peptide synthesis and chemical protein synthesis.

(3) Genomics/Functional Genomics & Biochip technologies. DNA microarray technology has made it possible to look at differential transcription profiles at the whole genome scale. Research in our group focuses on using this powerful technology to look at how natural products affect human diseases (cancer, TB, etc.) at their genetic levels. With the information obtained, ultimately we hope to be able to design better drugs that combat these diseases. In addition, we are interested in developing next-generation biochips (protein chips, peptide chip, small molecule chips, etc.), which we believe will play a major role in biotechnology in the post-genomic era. An automatic microarray spotter has been set up in the lab. Together with our expertise in combinatorial chemistry, organic synthesis and molecular biology, we are currently exploring a number of approaches, each of which will lead to high-throughput deposition of thousands of different functional molecules (proteins, peptides, small molecules, etc.) onto different locations of a microscope glass slides (1" x 2"

.

2002-2009(2009 部分未记入）

JACS 5,
Angew 3,
Org. lett 11,
Chemical Communications 6,
Chemistry A European Journal 1,

有兴趣的可以访问下面的链接，也可以直接发CV给老板。

http://www.chemistry.nus.edu.sg/ ... mic_staff/yaosq.htm

http://staff.science.nus.edu.sg/~syao/index.html

Email: chmyaosq@nus.edu.sg

[ Last edited by Chengxm on 2009-8-12 at 22:52 ]

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