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新加坡国立大学
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新加坡国立大学生物科学系林哲望课题组招收生物化学与细胞生物学方向的博士生2名。博士生将提供全额奖学金，2022年1月或者2022年8月入学，博士学业在四年内完成。感兴趣的同学请把简历发到zlin@nus.edu.sg The laboratory of Assistant Professor LIN Zhewang at the Department of Biological Sciences, National University of Singapore (NUS) is seeking creative and highly motivated postdoctoral fellows and graduate students with backgrounds in chemical biology or cell biology to join us. Our group integrates chemical, biochemical and cell biology approaches to discover and understand novel co-translational pathways that determine the fate of newly synthesized proteins and the associated mRNAs. Such co-translational molecular network is an emerging and under-examined area of research in a wide range of diseases, including infectious diseases, neurodegenerative disorders and cancers. We aim to capture, identify and characterize the co-translational factors directly involved in these disease processes. These interactions are challenging to study due to the dynamic and transient nature of these co-translational events. We recently developed a site-specific photo-crosslinking strategy, which allows us to capture and identify the cellular factor that mediates the specific co-translational degradation of tubulin mRNA during tubulin autoregulation (Lin et. al. Science 2020, see BioArt article: https://mp.weixin.qq.com/s/kg-FWfht6Dv1KzBlLyWxiw). This novel approach not only solves the long-standing question of how tubulin autoregulation is controlled at the molecular level, but also serves as a blueprint for the identification of other co-translationally acting factors. Our research is generously funded by the NUS Presidential Young Professorship (PYP) start-up grant. Graduate students will be fully supported by scholarships from NUS, including tuition fees and living allowances. We are currently seeking graduate students for Jan 2021 and Aug 2022 enrollments. Qualifications for PhD applicants: •Bachelor’s degree or Master’s degree in chemical biology, biochemistry, cell biology or related fields. •Prior research experiences in molecular biology. •First author research papers in internationally peer-reviewed journal will be an advantage. Students interested in pursuing a PhD degree at NUS are encouraged to email a copy of CV (with a list of research experiences, if any) to Dr. LIN Zhewang at zlin@nus.edu.sg. Selected Publications: •Z. Lin, I. Gasic, V. Chandrasekaran, N. Peters, S. Shao, T.J. Mitchison, R.S. Hegde. “TTC5 mediates autoregulation of tubulin via mRNA degradation.” Science 367, 100-104 (2020) •Z. Lin, M.Dong, Y. Zhang, E. Lee, H. Lin. “Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification.” Nat. Chem. Biol. 12, 995-997 (2016) •Z. Lin, X. Su, W. Chen, B. Ci, S. Zhang, H. Lin. “Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis.” J. Am. Chem. Soc. 136, 6179-6182 (2014) •Z. Lin, D. Yu, Y. N. Sum, Y. Zhang. “Synthesis of Functional Acetylene Derivatives from Calcium Carbide.” ChemSusChem 5, 625-8 (2012) Full list of publication: https://pubmed.ncbi.nlm.nih.gov/?term=zhewang+lin Webpage: https://www.dbs.nus.edu.sg/staffs/lin-zhewang/?cid=59 |
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