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stojkovic铜虫 (小有名气)
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[交流]
ingavirin的结构
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| 请问有哪位高人知道，俄罗斯商品名为ingavirin的药物的化学结构？ |
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yalefield
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Therapeutic efficacy of Ingavirin, a new Russian formulation against influenza A virus (H3N2) Loginova SIa, Borisevich SV, Maksimov VA, Bondarev VP, Nebol'sin VE. Antibiot Khimioter 2008; 53(7-8):27-30. English Abstract Investigation of the therapeutic efficacy of Ingavirin (Valenta Farmacevtica, Russia) against influenza virus A (H3N2) vs. Tamiflu, Remantadin and Arbidol showed that in daily doses of 15 and 20 mg/kg (equal by the efficacy to the human doses of 90 and 120 mg) Ingavirin was effective in protection of the albino mice infected by the virus in a dose of 10 to 15 LD50. The protective efficacy was 38.3-39.2% and the increase of the average lifespan amounted to 4.2-4.4 days. The Ingavirin efficacy was comparable with that of Remantadine, markedly exceeded that of Arbidol and was lower than that of Tamiflu. Investigation of the Ingavirin influence in doses of 15 and 20 mg/kg on the dynamics and level of the influenza virus A/Aichi/2/68 reproduction in the lungs of the infected albino mice weighing 10-12 g revealed that during the whole observation period in the doses tested Ingavirin was effective in inhibition of the influenza virus reproduction. During the whole period of the observation (5 days) Ingavirin was effective in inhibiting the formation of the virus specific hemagglutinin in the target organ. [全文] 俄语 [ Last edited by yalefield on 2009-8-4 at 20:50 ] |
3楼2009-08-04 20:49:05