²é¿´: 1500  |  »Ø¸´: 6
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

danwangcn

гæ (СÓÐÃûÆø)

[½»Á÷] ÃÀ¹úÂéÊ¡´óѧҽѧԺ³ÏƸ²©Ê¿ºó - ·Ö×Ó¼°Ï¸°ûÉúÎïѧ ÒÑÓÐ1È˲ÎÓë

ʵÑéÊÒPI£ºÍõµ¤£¨https://profiles.umassmed.edu/display/18404600£©
ʵÑéÊÒÖ÷Ò³£ºhttps://www.umassmed.edu/wanglab/
ѧУ£ºÂéÊ¡´óѧҽѧԺ(https://www.umassmed.edu) ÂéÊ¡´óѧҽѧԺ¶à¸ö¿ÆÑз½Ïò´¦ÓÚÃÀ¹úÁìÏȵØÎ»£¬AAV»ùÒòÖÎÁÆ¡¢RNAÉúÎïѧ¼°ÖÎÁƸü´¦ÓÚÊÀ½ç¶¥¼¶Î»Öá£
Ժϵ£º»ùÒòÖÎÁÆÖÐÐÄ£¨https://www.umassmed.edu/gtc/£©£¬RNAÖÎÁÆÑо¿Ëù(https://www.umassmed.edu/rti/)
ʵÑéÊÒ¼ò½é£ºÊµÑéÊÒ»ùÓÚ³ÉÊì¼¼Êõƽ̨£¬×¢ÖØ¿ÆÑÐ˼·´´ÐºÍת»¯Ó¦Óá£ÖÂÁ¦ÓÚ»ùÓÚAAVÔØÌåµÄ¶àÖÖ¼²²¡»ùÒòÖÎÁÆ£¬»ùÒò±à¼­ºÍRNAÖÎÁƵŤ¾ßƽ̨Ñз¢¼°×ª»¯£¬AAVÉúÎïѧ£¬AAVÔØÌ忪·¢ÓëÉú²ú¡£
Ñо¿·½Ïò¼ò½é£º»ùÒòÖÎÁÆÊǵ±Ç°ÉúÎïҽѧÁìÓòÒ»´óÈȵ㣬¾­¹ý¼¸Ê®ÄêµÄ²¨ÕÛ£¬ÏÖÒÑÓжà¸ö»ùÒòÖÎÁÆÒ©Îï»ñÃÀ¹úFDAÅú×¼ÉÏÊУ¬²¢Óжà¸öÒ©ÎïÔÚÉóÅúÖС£ÏÙÏà¹Ø²¡¶¾£¨AAV£©ÎªÊ×Ñ¡ÌåÄÚ»ùÒòµÝËÍÔØÌ壬×ÔÈ»³ÉΪÑо¿½¹µã(×ÛÊö£ºWang, D. et al. Nat Rev Drug Discov 2019)¡£RNAÖÎÁÆ£¬»ùÒò±à¼­µÈÒ²ÊǽüÄêÑо¿Èȵ㡣ʵÑéÊÒ½áºÏAAV»ùÒòÖÎÁÆ£¬RNAÉúÎïѧ£¬»ùÒò±à¼­µÈÉúÎï¼¼Êõƽ̨£¬ÖÂÁ¦ÓÚ¿ª·¢´´ÔìÐԵķÖ×ÓÖÎÁÆ·½·¨(×ÛÊö£ºWang, D. et al. Cell 2020)¡£Ö÷Òª²ÉÓöàÖÖСÊó¼²²¡Ä£ÐÍ̽Ë÷ÌåÄÚÖÎÁÆ·½·¨£¬²àÖØÉñ¾­ÏµÍ³¼²²¡¡£Í¬Ê±£¬²ÉÓöàÖÖʵÑé·½·¨½øÐÐAAV»ù´¡ÉúÎïѧÑо¿£¬°üÀ¨Ï¸°ûÉúÎïѧ¼°ÉúÎﻯѧ¡£Ñо¿³É¹û·¢±íÓÚNature Biotechnology, Nature Communications, Advanced Science ÒÔ¼°¶àÖÖ»ùÒòÖÎÁÆÖ÷Á÷ÆÚ¿¯.
ְλ¼ò½é£ºÑо¿ÓëAAVÔØÌåÉú²úÏà¹ØµÄ·Ö×Ó¼°Ï¸°û»úÖÆ£¬²¢¼ÓÒÔת»¯Ó¦Ó᣸ÿÎÌâÓÚ2020Äê12Ô»ñ³ä×ã¿ÆÑлù½ðÖ§³Ö¡£
ÉêÇëÈËÒªÇ󣺲©Ê¿Ñ§Î»¡£ÓÐgenetic screenÏà¹Ø¾­Ñ飨ÈçCRISPR screen£©£¬»òÊìϤ¸ßͨÁ¿²âÐò£¨Illumina£¬PacBio£©£¬°üÀ¨ÊµÑé²Ù×÷¼°Êý¾Ý·ÖÎö¡£ÊìϤ»ùÓÚCRISPRµÄ»ùÒò±à¼­·½·¨£¨ÈçCas9£¬ dCas9£©¼°Ó¦Óã¨È罨Á¢Ï¸°ûϵ£©¡£Ï£ÍûÓÐÁ¼ºÃµÄÓ¢Óï½»Á÷ÄÜÁ¦£¬°üÀ¨¿ÚÓïºÍд×÷¡£
¾Íҵǰ¾°£ºAAV»ùÒòÖÎÁÆÑ§Êõ½ç·¢Õ¹ºÜ¿ì£¬½üÄêµÃµ½´óÁ¿×ʽðÖ§³Ö¡£¹¤Òµ½ç¾ÍÒµ»ú»áÒ²ºÜ¶à£¬¸½½ü²¨Ê¿¶ÙµØÇøÎª¸ÃÁìÓò¹«Ë¾¾Û¼¯µØ¡£
ÉêÇë²ÄÁÏ£ºÇ뽫¼òÀú£¬´ú±íÐÔÂÛÎÄPDF£¨1-3ƪ£©£¬ÈýÎ»ÍÆ¼öÈËÁªÏµ·½Ê½ÒÔȫӢÎÄ·¢ÖÁPIÓÊÏ䣺dan.wang@umassmed.edu
»Ø¸´´ËÂ¥

» ²ÂÄãϲ»¶

» ±¾Ö÷ÌâÏà¹ØÉ̼ÒÍÆ¼ö: (ÎÒÒ²ÒªÔÚÕâÀïÍÆ¹ã)

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

danwangcn

гæ (СÓÐÃûÆø)

4Â¥2021-01-31 10:47:31
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 7 ¸ö»Ø´ð

danwangcn

гæ (СÓÐÃûÆø)

2Â¥2021-01-05 11:31:57
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

danwangcn

гæ (СÓÐÃûÆø)

3Â¥2021-01-12 11:44:48
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

danwangcn

гæ (СÓÐÃûÆø)

·Ç³£»¶Ó­ÏÖ¾Ó¹úÄÚµÄÉêÇëÈ˵ݽ»¼òÀú¡£ÎÒÃÇ¿ÉÒÔÏÈÈÏʶ/ÃæÊÔÆðÀ´¡£µÈÒßÇé/ǩ֤/º½°àµÈÎÊÌâÓÐËùºÃת£¬¿ÉÒÔ¿ªÊ¼°ìÀíÈëÖ°¡£
6Â¥2021-02-09 00:34:43
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 331Çóµ÷¼Á +3 zzZ&zZ 2026-03-03 3/150 2026-03-04 10:37 by aaaÏÔ¿¨Åú·¢Íõ×Ü
[¿¼ÑÐ] »¯Ñ§ 0703Çóµ÷¼Á ×Ü·Ö293 Ò»Ö¾Ô¸211 +7 ÍÁÍÁС³æ 2026-03-03 7/350 2026-03-04 10:15 by qingfeng258
[¿¼ÑÐ] 312Çóµ÷¼Á +3 ´×¾«»ªÁËһϷ¢Ï 2026-03-03 5/250 2026-03-04 09:23 by lbsjt
[¿¼ÑÐ] ²ÄÁÏ328Çóµ÷¼Á +5 Ò»¸öÂܲ·02 2026-03-03 5/250 2026-03-04 09:10 by gaoxiaoniuma
[¿¼ÑÐ] 266Çóµ÷¼Á +5 ÍÛÈûÍõ˧ 2026-03-03 5/250 2026-03-04 02:47 by ÎÞи¿É»÷111
[¿¼ÑÐ] 0856²ÄÁϹ¤³Ì£¬³õÊÔ313µ÷¼Á +7 Âô¸ö¹Ø×Ó°É 2026-03-03 7/350 2026-03-03 21:33 by L135790
[¿¼ÑÐ] 085600²ÄÁÏÓ뻯¹¤µ÷¼Á 280·Ö +10 yyqqhh 2026-03-03 10/500 2026-03-03 18:37 by 386661696
[¿¼ÑÐ] Ò»Ö¾Ô¸»ªÖпƼ¼´óѧ£¬»¯Ñ§×¨Òµ344·Ö£¬Çóµ÷¼Á +6 ÐÏxing1 2026-03-02 6/300 2026-03-03 15:46 by stewie_jz
[¿¼ÑÐ] ¼ÆËã»úѧ˶ ·ÖÊý285Çóµ÷¼Á +4 glwshine 2026-03-02 5/250 2026-03-03 14:27 by kingѽ
[¿¼ÑÐ] ²ÄÁϹ¤³Ìר˶283Çóµ÷¼Á 5+8 £¬£¡£¿ 2026-03-02 10/500 2026-03-03 12:01 by EBSD
[¿¼ÑÐ] ²ÄÁϹ¤³ÌÇóµ÷¼Á +3 1431251 2026-03-03 3/150 2026-03-03 11:58 by EBSD
[¿¼ÑÐ] »¯¹¤¾©Çø271Çóµ÷¼Á +7 11ing 2026-03-02 7/350 2026-03-03 07:30 by ÀûºÃÀûºÃ.
[¿¼ÑÐ] 0854¸´ÊÔµ÷¼Á 276 +5 wmm9 2026-03-01 7/350 2026-03-03 02:49 by xiadaiyang
[¿¼ÑÐ] Ò»Ö¾Ô¸¶«±±´óѧ²ÄÁÏר˶328£¬Çóµ÷¼Á +3 shs1083 2026-03-02 3/150 2026-03-02 17:27 by houyaoxu
[¿¼ÑÐ] 0856»¯¹¤×¨Ë¶Çóµ÷¼Á +15 ¶­boxing 2026-03-01 15/750 2026-03-02 15:06 by »Î»Î²»Ðí»Î
[»ù½ðÉêÇë] ´Ë³É¹û²»Äܵ¼ÈëÔ­Òò£ºÔªÊý¾Ý±ØÌîÐÅÏ¢²»ÍêÕû£¬¿É ½øÐв¹³ä¡£ +4 Kittylucky 2026-03-02 5/250 2026-03-02 11:07 by jurkat.1640
[»ù½ðÉêÇë] ³É¹ûϵͳ·ÃÎÊÁ¿´ó£¬ÇëһСʱºóÔÙ³¢ÊÔ¡£---NSFCɶʱºòºÃŶ£¬ÒѾ­Á½ÌìÕâÑùÁË +4 NSFC2026ÎÒÀ´ÁË 2026-02-28 4/200 2026-03-01 22:37 by ÌúÃÅ˨
[¿¼ÑÐ] 272Çóµ÷¼Á +6 ÌïÖÇÓÑ 2026-02-28 6/300 2026-03-01 21:40 by ¹«èªåÐÒ£
[¿¼ÑÐ] »¯¹¤299·ÖÇóµ÷¼Á Ò»Ö¾Ô¸985Âä°ñ +5 ÎûÎû(*^¦Ø^*) 2026-03-01 5/250 2026-03-01 19:47 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] 328Çóµ÷¼Á +3 aaadim 2026-03-01 5/250 2026-03-01 17:29 by njzyff
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û