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Strawberrix新虫 (小有名气)
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Genetic underpinnings of human tinnitus (荷兰马斯特里赫特大学CSC项目 2021）
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project title: the genetic underpinnings of human tinnitus project leader: dr. m. adriaens function: assistant professor, maastricht centre for systems biology (macsbio) collaborators: prof. i. c. w. arts (promotor) dr. m. moerel dr. e. george proposal (250 words): introduction: tinnitus is an unsolved neuro-otological problem, affecting the quality of life of millions of people worldwide. in spite of extensive research, the biological mechanism underlying tinnitus is still debated. while previous studies showed that tinnitus is moderately heritable, research into its genetic basis often resulted in inconsistent findings hindering the development of an effective treatment. the conflicting results of tinnitus research may in part be due to the heterogeneity of this disorder. different tinnitus subtypes likely exist, and each tinnitus subtype may be caused by a different biological mechanism. objectives and methods: the candidate will work at the maastricht centre for systems biology (macsbio), a young, interdisciplinary institute at maastricht university aiming to integrate biological data from different empirical domains. the candidate will analyze a unique dataset, that includes genetic and brain data of individuals with and without tinnitus, with state-of-the-art systems biology tools. the objectives are (1) to identify tinnitus subtypes by the data-driven grouping of patients according to their similarity in brain anatomy and function, and (2) to characterize each tinnitus subtype by genes and biological mechanisms whose modifications represent risk factors for tinnitus development. impact: if successful, results of the proposed research identify tinnitus subtypes and provide insight into the neurobiological mechanism underlying tinnitus for each subtype. the clinical impact of such research findings would be profound, as they shed light on a complex disorder and may ultimately permit the matching of tailormade clinical care to an individual tinnitus patient. requirements candidate: highly motivated student with good english communication skills and proactive and resolute attitude. a background in neuroscience, engineering, systems biology, or related fields, and good programming and data analysis skills are required. interested candidate should send their cv, transcript (bachelors, and masters if applicable), to dr. michiel adriaens, michiel.adriaens@maastrichtuniversity.nl. please ask dr. michiel adriaens for further information. The deadline for the initial application is 28th Nov, 2020. keywords: 人类健康与疾病的生物学基础 / biological foundations of human health and diseases 前沿技术 / frontier technologies top 5 selected publications: 1. o'donovan, s. d., lenz, m., vink, r. g., roumans, n. j. t., de kok, t. m. c. m., mariman, e. c. m., peeters, r. l. m., van riel, n. a. w., van baak, m. a. & arts, i. c. w. (2019). a computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data. plos computational biology, 15(10), e1007400. 2. adriaens, m. e., lodder, e. m., moreno‐moral, a., Šilhavy, j., heinig, m., glinge, c., . . . pravenec, m. (2018). systems genetics approaches in rat identify novel genes and gene networks associated with cardiac conduction. journal of the american heart association, 7(21), e009243. 3. heinig, m.*, adriaens, m. e.*, schafer, s., van deutekom, h. w. m., lodder, e. m., ware, j. s., . . . hubner, n. (2017). natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. genome biology, 18(1), 170. doi:10.1186/s13059-017-1286-z. * shared first authorship 4. berlot e, arts r, smit j, george e, gulban of, moerel m, stokroos r, formisano e, de martino f. (2020) a 7 tesla fmri investigation of human tinnitus percept in cortical and subcortical auditory areas. neuroimage clin., 25. doi: 10.1016/j.nicl.2020.10216. 5. moerel m, de martino f, uğurbil k, formisano e, yacoub e. (2018). evaluating the columnar stability of acoustic processing in the human auditory cortex. the journal of neuroscience, 38, 7822╟7832. https://doi.org/10.1523/jneurosci.3576-17.2018. |
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