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Strawberrix新虫 (小有名气)
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Systems biology of human memory（荷兰马斯特里赫特大学), CSC项目2021
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project title: systems biology of human memory: from relevant gene networks to brain activation patterns project leader: dr. m. moerel function: assistant professor collaborators: prof. p. de weerd (promotor) dr. m. adriaens proposal (250 words): introduction: understanding episodic memory formation is among the most scientifically and clinically relevant challenges of this century. progress in this field is hampered by the lack of integration among disparate research fields. here, we propose an ambitious integration across different inquiry levels, ranging from genetics to whole brain network behaviour, expected to boost scientific insight in episodic memory, and therapy development for memory deficits. objectives: using existing human databases combining genetic data, (f)mri data, and data from behavioural memory tests, we aim to identify key genes and molecular pathways linked to the efficiency of memory formation as operationalized in functional and structural mri connectivity changes. setting and methods: the candidate will work at the maastricht centre for systems biology (macsbio), a successful, interdisciplinary institute at maastricht university. in study 1 and 2 you will work with existing data from the human connectome project consisting of behavioural, neuroimaging, and genetic data of 1,200 twins and their non-twin siblings. computational models will be used to test effects of selected cellular pathways on network interactions and memory performance, thereby integrating observations across spatial scales and disciplines. in study 3, you will experimentally test hypothesized effects of specific genes/pathways on memory formation derived from studies 1-2, using participant groups with distinct genetic profiles selected from a large, genetically screened cohort. impact: the combination of analysing a rich database along with the design and execution of a tailored experiment provides a unique opportunity to achieve novel insights into memory formation in the living human brain. requirements candidate: highly motivated student with good english communication skills and proactive and resolute attitude. a background in neuroscience, engineering, systems biology, or related fields, and good programming and data analysis skills are required. interested candidate should send their cv, transcript (bachelors, and masters if applicable), to dr. michelle moerel, michelle.moerel@maastrichtuniversity.nl. please ask dr. michelle moerel for further information. The deadline for the initial application is 28th Nov, 2020. keywords: 人类健康与疾病的生物学基础 / biological foundations of human health and diseases 前沿技术 / frontier technologies 基础研究 / basic research 三、人文与社会科学领域 / humanities and social sciences top 5 selected publications: 1. vallès a, boender aj, gijsbers s, haast ra, martens gj, de weerd p (2011) genomewide analysis of rat barrel cortex reveals time- and layer-specific mrna expression changes related to experience-dependent plasticity. j neurosci. 31: 6140-58. 2. moerel m, de martino f, kemper vg, schmitter s, vu at, uğurbil k, formisano e, yacoub e. (2017) sensitivity and specificity considerations for fmri encoding, decoding, and mapping of auditory cortex at ultra-high field. neuroimage. doi: 10.1016/j.neuroimage.2017.03.063. if = 5.812. 3. moerel, m., de martino, f., uğurbil, k., formisano, e., & yacoub, e. (2018). evaluating the columnar stability of acoustic processing in the human auditory cortex. the journal of neuroscience, 38, 7822╟7832. https://doi.org/10.1523/jneurosci.3576-17.2018. if = 6.074. 4. adriaens, m. e., lodder, e. m., moreno‐\moral, a., Šilhavy, j., heinig, m., glinge, c., . . . pravenec, m. (2018). systems genetics approaches in rat identify novel genes and gene networks associated with cardiac conduction. journal of the american heart association, 7(21), e009243. if = 5.117. 5. heinig, m., adriaens, m. e., schafer, s., van deutekom, h. w. m., lodder, e. m., ware, j. s., . . . hubner, n. (2017). natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. genome biology, 18(1), 170. doi:10.1186/s13059-017-1286-z. if = 13.214. |
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