| 查看: 1984 | 回复: 57 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 chu_mouse 的 3 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
清华药学院储凌课题组招聘有机化学、化学生物学、生物方向博后及研究助理
|
|||
|
About the PI Ling Chu was born and raised in Hefei, Anhui, China. He received a B.S. degree in Chemistry from the University of Science and Technology of China in 2012. He completed his Ph.D. study at the Scripps Research Institute, where he conducted research with Prof. Jin-Quan Yu on the development of Palladium-catalyzed C-H activation reactions. After completing his Ph.D. in 2017, he switched his research field to chemical biology and worked with Prof. Alanna Schepartz and Prof. Derek Toomre as a Brown-Coxe postdoctoral fellow at Yale School of Medicine. In the Schepartz/Toomre lab, he developed new chemical biology tools for two-color long-time lapse live-cell super-resolution imaging. He then joined Prof. Craig Crews’ lab in 2019 as a postdoctoral associate, where he led the development of first PROTAC capable of degrading oncogenic KRASG12C. Ling will join School of Pharmaceutical Sciences, Tsinghua University as an assistant professor in 2021. His research interest lies at the interface of chemistry and biology. Website: chu-lab.org Email: chu_lab@126.com About the research New chemical biology tools to explore the beyond-rule-of-5 drug space There is an increasing need to pursuit less druggable targets that offer high potential for the development of new therapeutic agents and may require beyond-rule-of-5 (bRo5) molecules in order to take advantage of these opportunities. Nevertheless, bRo5 chemical space remains relatively unexplored, most likely due to the perceived non-oral properties, increased complexity of compounds in this space and the synthetic chemistry challenges associated with its navigation. There is a pressing need to develop new technologies for the discovery and oral delivery of bRo5 drugs. We will develop new chemical biology approaches that enable phenotypic screening of large, de novo bRo5 compound libraries inside living cells. Such efforts could potentially yield novel hits for “undruggable” targets. The strategies used here will be further pursued for applications in oral delivery of bRo5 compounds. Affecting protein stability as a new strategy to target KRAS The Kirsten rat sarcoma viral oncogene homologue (KRAS) gene is one of the most frequently mutated oncogenes in cancer. KRAS is mutated in ～30% of human cancers and is one of the most sought-after targets for pharmacological modulation. Despite its well-recognized importance in cancer malignancy, continuous efforts in the past three decades failed to develop approved therapies for KRAS mutant cancer. Recent efforts in direct targeting KRASG12C have resulted in small molecule inhibitors that showed great promise in early clinical trials. However, G12C mutant only represents a small percentage of patients with oncogenic KRAS mutations. To explore a general strategy to target KRAS, we will combine chemical screen and genetic screen to identify small molecules and genes that can destabilize KRAS across different mutant KRAS cell lines. Results from these screens will provide novel therapeutic leads and mechanistic insights of KRAS degradation pathway. Leveraging these findings, we hope to develop next-gen small molecule therapeutics for the treatment of KRAS mutant cancer. New tools for live-cell protein labeling and super-resolution imaging Proteins are the essential components in cell function. To understand the function of proteins in living cells, it is important to know the properties of proteins in the temporal and spatial context of the cell. Currently, live-cell protein labeling and imaging technologies have several limitations: 1) Widely adopted tools for live-cell protein labeling have a large size (20-30kDa), giving rise to concerns that they may interfere with protein folding, trafficking, activity, and interactions; 2) Fluorescence proteins or small molecule dyes bleach quickly under super-resolution imaging conditions, thus prevent long-term protein imaging. To solve these problems, we will develop short peptide tags for site-specific protein labeling in live cells. Such tags contain only a few amino acids and will have minimal perturbation of protein function in live cells. We will also develop bleaching-resistant live cell protein imaging tools that allow biologists to visualize the dynamics of proteins at the nanoscopy level (resolution<50 nm) with unlimited “photon budget”. Training We are an interdisciplinary research group working at the interface of chemistry and biology. Students in the lab will receive multidisciplinary training in experimental techniques ranging from synthetic chemistry to fluorescence microscopy to cellular studies. Representative skill sets in the group are given below. Chemical tools: organic synthesis, catalysts, medicinal chemistry, peptide synthesis Cell culture: mammalian cell lines, primary cell cultures Cell imaging: Confocal microscopy, STED, single-molecule microscopy, flow cytometry Molecular biology: Cloning, PCR, CRISPR Biochemistry: Protein purification, western blotting About the job We are actively recruiting. If you are passionate about chemical biology and drug discovery, come join us! Don’t hesitate to reach out to Dr. Chu at chu_lab@126.com Postdoc positions in biology Candidates should hold a PhD degree in cell biology, biochemistry, chemical biology, pharmacology or related fields. Experiences in phenotypic high-throughput assay or CRISPR screen are preferred but not required. If you are interested in joining the lab, please send your CV, research summary, and contact information of three referees to Dr. Chu at chu_lab@126.com. Postdoc positions in chemistry Candidates should hold a PhD degree in organic chemistry, medicinal chemistry or related fields. Experiences in transition-metal catalysts are preferred but not required. If you are interested in joining the lab, please send your CV, research summary, and contact information of three referees to Dr. Chu at chu_lab@126.com. Research assistants/Technicians Candidates should hold an MS or BS degree in chemistry or biology. If you are interested in joining the lab, please send your CV and contact information of three referees to Dr. Chu at chu_lab@126.com. Competitive salaries will be provided for qualified applicants. [ Last edited by chu_mouse on 2020-11-1 at 02:29 ] |
回复此楼» 猜你喜欢
本人考085602 化学工程 专硕
已经有8人回复
-
求老师收留调剂
已经有5人回复
-
机械专硕调剂
已经有3人回复
-
东华理工大学化材专业26届硕士博士申请
已经有6人回复
-
欢迎申博同学联系
已经有7人回复
-
东南大学364求调剂
已经有3人回复
-
326求调剂
已经有4人回复
-
化学工程321分求调剂
已经有5人回复
-
材料工程专硕274一志愿211求调剂
已经有4人回复
-
311求调剂
已经有5人回复
» 抢金币啦！回帖就可以得到:
-
西湖大学工学院智能微型机器人实验室博士后招聘启事
+4/248
-
测试█TEM/ EPR/ XPS/PY-GCMS/TG-IR/XRF/BET/MIP/核磁/EA/ICP，VX: 761711562。
+1/87
-
专业技术开发及第三方检测
+1/87
-
物理学 调剂
+1/86
-
物理学 调剂
+1/84
-
厦门大学电池工况表征博士后招聘（固态电池 / 层状氧化物正极 / 原位-工况表征方向）
+1/78
-
福建师范大学招收2026年化学、材料硕士3-4名
+1/78
-
【武汉高校】【新能源材料与器件课题组】 招收优秀硕士调剂生！！！
+5/70
-
何时使用 CODA™ 科里奥利质量流量仪表- 艾里卡特（Alicat）
+2/52
-
南开大学罗景山教授课题组招聘博士后（光/电催化、钙钛矿光伏方向）
+2/34
-
0854电子信息调剂，集成电路，芯片方向，闽南师范大学光电芯片研发实验室
+1/33
-
华南师范大学（211）博士招生- 电子、自动化、机械、生物学、物理相关专业
+1/29
-
瑞典林雪平大学（linköping university）诚聘 氮化物基无机材料方向 博士后1名
+1/27
-
新疆大学招收学硕调剂
+1/26
-
上海科技大学招收有机化学方向招收2026级工程博士
+1/9
-
西京学院土木水利 2026 级研究生招生相关说明
+1/8
-
青岛科技大学高分子学院---生物大分子医学（BM3)团队---招收硕士生和博士生
+1/7
-
重庆大学药学院闫海龙课题组拟招收2026年申请考核制博士研究生
+1/5
-
徐工-环境工程学院-招收调剂硕士
+1/1
-
澳门理工大学人工智能药物发现中心招收2026级博士研究生（申请-考核制）
+1/1
42楼2020-11-15 11:00:56
简单回复
tzynew3楼
2020-10-29 11:12
回复
chu_mouse(金币+1): 谢谢参与
8 发自小木虫Android客户端
tzynew4楼
2020-10-29 11:12
回复
tzynew5楼
2020-10-29 11:12
回复
encryption13楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
ro1114楼
2020-10-29 12:50
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
howtoge8楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
icanspll7楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
zzhello11楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
likecitywo12楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
yaqianye9楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
shehuifei10楼
2020-10-29 12:49
回复
chu_mouse(金币+1): 谢谢参与
。 发自小木虫Android客户端
TTTiger2楼
2020-10-29 10:55
回复
chu_mouse(金币+1): 谢谢参与
好 发自小木虫IOS客户端
